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10 Best CBD Oil for Arthritis: Top CBD Brands Reviewed 2022

Arthritis is a severe and debilitating condition that can affect people of all ages (although it’s more prominent in older individuals). The latest statistics from the Centers for Disease Control (CDC) reveal that up to 58.5 million Americans over 18 had some form of arthritis in 2015.

But an aging population coupled with the repetitive daily tasks we perform—such as computer work or physical labor – likely means the number will be much higher now in 2022. Alarmingly, the CDC predicts that arthritis patients will hit 78.4 million by 2040.

Numbers aside, it’s pretty clear that arthritis poses a considerable risk to people’s health, and it’s not going away anytime soon.

Although research is still ongoing, there’s strong anecdotal and preliminary evidence suggesting CBD may help address some of the symptoms associated with arthritis. As a result, cannabidiol may be a viable alternative for those concerned about medication side effects or dependence on painkillers.

To effectively address arthritis symptoms, you need a CBD oil that’s potent, pure, and safe. Unfortunately, there are now thousands of brands, making it hard to find quality products. We’ve compiled our ten best choices for CBD oil based on several benchmarks to measure quality, strength, safety, and transparency to narrow down the list.

Is CBD Oil Good for Arthritis?

We can’t conclusively say CBD oil is good for arthritis, but the ever-growing pile of preliminary research seems to support that conclusion. It’s also important to consider the mounds of anecdotal evidence that poured in long before experts took CBD seriously. Judging by the number of people who use CBD for arthritis pain and inflammation, the case for cannabidiol gets stronger every day.

For example, an Arthritis Foundation poll surveyed several arthritis patients, revealing some surprising information. According to the survey, 79% of respondents “are currently using CBD, have used it in the past or are considering using it.” Meanwhile, 29% say they currently use it for arthritis symptoms.

Interestingly, the products used are almost evenly split between oils and creams. Of the active CBD users polled, 62% use liquid CBD (oils, tinctures, beverages), while 55% use topical CBD products (creams, balms, lotions).

How CBD Oil Helps with Arthritis

If you plan to try CBD oil for arthritis, it’s helpful to understand how CBD oil helps with arthritis. The mechanism of action is a lot more complex than with other cannabinoids, like THC. But that’s one of the many reasons CBD is so versatile.
Most cannabinoids bind to the CB1 and CB2 receptors that form our endocannabinoid system. This network of receptors and internally-produced cannabinoids keeps our body in balance or “homeostasis.”

THC, for example, binds to both the CB1 and CB2 varieties. Some cannabinoids bind to one or the other. CBD, however, has little affinity for either. Instead, it works through different receptor pathways, including:
● GPR-55 orphan receptors
● TRPV1 vanilloid receptors
● PPAR receptors
● Serotonin receptors

Those pathways serve several functions, including pain regulation, appetite, sleep, and mood to name a few. In the case of arthritis, however, the TRPV1 or “vanilloid” receptors are primarily responsible for mitigating the condition’s symptoms. Researchers induced inflammation in rat subjects during a 2009 study published in the British Journal of Pharmacology.

Based on the observations, CBD’s interaction with the TRPV1 receptors contributed to the anti-inflammatory benefits that also helped reduce pain.

Anti-inflammatory

Inflammation is a textbook arthritis symptom inevitably accompanied by pain. Evidence suggests that CBD may help reduce joint pain related to arthritis. For instance, a 2017 research paper in the academic journal Pain studied the anti-inflammatory properties of CBD. Experts applied a CBD-infused topical on rats with osteoarthritis. Although the rodents didn’t show immediate improvement, observers noticed a significant reduction in inflammation by the 14th day of their experiment.

Analgesic 2019 Gallup poll shows 14% of Americans use CBD. But out of all the potential symptoms, 40% of those CBD consumers—the most significant chunk—use it for pain.

This pattern is even more prominent when you look at the Arthritis Foundation’s poll we covered earlier. That survey determined 94% of CBD users with arthritis took cannabidiol for pain.
But one notable piece of research is a 2008 review of existing literature by famous cannabis researcher and medical expert Ethan Russo. Russo is known for “Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects,” a paper where he proposed and explained the synergistic “entourage effect” that we frequently refer to today.

Russo examined studies on synthetic (prescription) cannabinoids and external cannabinoids (phytocannabinoids). Unsurprisingly, he concluded that, based on existing evidence, CBD and other cannabinoids might help manage chronic pain.

CBD was far from mainstream in 2008, but subsequent research—such as that mentioned above—has helped support Russo’s conclusions.

Best CBD Oil for Arthritis: Top CBD Brands Reviewed

If you’re looking to try full-spectrum CBD oil for arthritis pain, it’s hard to find the right product—especially if you’re new to CBD. You need a clean, tested, potent CBD oil for the best results.
To help determine the best CBD oil for arthritis, we’ve compiled a list of top ten vendors based on our objective benchmarks (more on that later).

1. Colorado Botanicals: Best CBD Oil for Arthritis

Colorado Botanicals was established in 2017, offering a trustworthy and effective line of inexpensive Full and broad-spectrum CBD products. Today, they carry an even more extensive selection of hemp supplements, but they have never wavered from their commitment to transparency, safety, and quality. We’re proud to give Colorado Botanicals our top spot as the Best CBD Oil for Arthritis.

Colorado Botanicals offers the best CBD oil for pain (or other possible uses). But we’re not the only ones to notice. Observer and Discover Magazine chose Colorado Botanicals as their top pick as “Best CBD Oil” and “Best CBD Oil for Pain,” respectively.

But Colorado Botanicals advantage isn’t just what you see on their shelves. Behind the scenes, those products are backed by quality assurance, sustainable farming, independent testing, and lab-grade production.

CO2 extraction is becoming the primary approach to quality CBD oils. It leaves no trace solvents, making it cleaner – albeit more complicated – than other methods. Unfortunately, the process also destroys many terpenes, cannabinoids, and other beneficial compounds. Typically, vendors artificially add terpenes from other plants to make up for the loss.
However, Colorado Botanicals perfected a proprietary CO2 extraction technique followed by an unmatched purification process that maximizes terpene, cannabinoid, and flavonoid retention for an all-natural product.

Colorado Botanicals full-spectrum CBD oil ranges in potency from 300 to 3,000mg of CBD per 30 ml bottle, but their 750mg Full-Spectrum CBD Oil—at 25 mg/ml—is strong enough to meet the needs of an average CBD user.

The already low price gets better with repeat shipping at a 15% discount.

2. CBDistillery

Based in Denver, Colorado, CBDistillery has grown by leaps and bounds since its founding in 2016. CBDistillery focuses on quality sourcing. They use Colorado hemp grown through “natural farming practices,” although they never mention “organic.” The vendor is also certified by the U.S. Hemp Authority.

All of the company’s CBD oils are very affordable. Veterans and active military personnel may further offset the cost with CBDistillery’s 30% military discount.
Regular customers can also save money by subscribing to a 20% discount on every order.

CBDistillery offers excellent value along with a range of CBD extract products. However, we feel the best option is their mid-range product. CBDistillery’s 1,000mg Full-Spectrum CBD contains 33 mg/ml of CBD, allowing it to address mild to moderate symptoms.

3. NuLeaf Naturals

Established in 2014, NuLeaf Naturals keeps its products pure and simple. Although they were strictly CBD-focused, their offerings expanded to CBG, CBN, and CBC oils. NuLeaf’s approach to hemp CBD is similar to that of Colorado Botanicals. Both prefer to focus on purity rather than flavors and other proverbial bells and whistles. One thing they haven’t done is expand beyond oils, topicals, and capsules. But this isn’t necessarily a bad thing. Rather than branch out to new options, they continue refining and perfecting the products that made them successful. Unfortunately, this can limit their customer base, but those that are loyal can expect to enjoy some of the purest CBD oils available. If you’re looking to try Nuleaf Naturals CBD oil, their 900mg Full-Spectrum CBD Oil is a perfect mid-range starting point.

4. Lazarus Naturals

Based out of Seattle, Lazarus Naturals grows its organic hemp in Oregon.

They offer CBD and other cannabinoid extracts in various sizes and options. Like most premium CBD vendors, they’ve since expanded into other extracts, adding CBG and CBN to some of their formulations.

One thing that stands out about Lazarus Naturals is their price. Customers can pick up a bottle of full-spectrum 2,400 mg 60 ml CBD oil for just $120.00. Lazarus Naturals also has one of the best return policies possible. You can return your unwanted items for free with a prepaid shipping label up to 90 days after receiving them.

We recommend the Lazarus Naturals High Potency 1,500mg Tincture. All of the oil products in this line contain 50 mg/ml, so our choice is based on volume and price.

5. Charlotte’s Web

Charlotte’s Web is one of the most established CBD brands. Originally opening in 2012, their high-CBD cannabis strains put cannabidiol on the map. The brand rose to prominence after a story went public about Charlotte Figi, a young girl whose severe epilepsy was controlled by the company’s CBD oil.

Charlotte’s Web isn’t the cheapest brand, but it’s not prohibitively expensive either. It helps that they offer a 20% discount for subscribers and an assistance program for veterans.

Charlotte’s Web sells 30 or 100 mg bottles in 7, 17, 25, 50, and 60 mg/ml concentrations. In our view, however, the best mid-range choice is their THC-Free CBD Oil at 25 mg/ml. The broad-spectrum product is perfect for moderate users and carries no THC.

6. Joy Organics

Joy Organics is among the few who can say their hemp is USDA Certified Organic, the highest tier possible.

Like CoBo, Joy says they use a proprietary CO2 extraction method that maximizes natural hemp compound retention. Of course, you can see that with lab test results available on each product page.
The company also offers decent potency options, ranging from 15 mg/ml to 75 mg/ml – all at surprisingly affordable prices. Customers can save even more with Joy’s 20% discount for subscribers.
We highly recommend Joy Organics Full-Spectrum 1350 MG Fresh Lime Organic CBD Tincture, popular among customers looking to try CBD for arthritis pain.
At 45 mg per serving, the product’s potency offers an excellent balance for beginners and intermediate CBD enthusiasts.

7. cbdMD

cbdMD embodies what success in the industry should look like. Opening in 2015, their company grew exponentially and now offers a diverse selection of CBD oils, edibles, skincare products, and more.

As far as potency is concerned, cbdMD tops our list. Their most potent product (7500 mg) contains a staggering 250 mg/ml in a 30 ml bottle – far above the 100 mg/ml cap we’ve seen so far with other companies.

Considering what they offer, cbdMD is quite affordable, with their strongest oil retailing for just $209.99 – a price that’s much lower with their 30% subscriber discount. The cbdMD Premium 750 mg CBD Oil Tincture is a solid medium-dose product that may help people who are trying to address arthritis pain and other symptoms. At 25 mg/ml, the concentration isn’t excessive for beginners yet also adequate for those with moderate needs.

8. Medterra

Established in 2017, Medterra is a bit of a youngster compared to some of its competitors. But despite its comparative inexperience, the CBD company has a lot to offer. Medterra only carries a handful of CBD products, but their formulas reflect the more advanced recipes that many companies adopted. Certain lines include other beneficial ingredients, like CBG and nutritional supplements.

What truly stands out about Medterra is its commitment to education. Their site is crammed with resources and news for beginners new to CBD. With such tools, it’s easy for anyone to get their feet wet as they enter the ever-growing world of hemp-derived CBD health supplements.

Customers looking for full-spectrum CBD oil can choose Medterra’s True Full-Spectrum oil at 50 mg/ml. The product is only available in 50 and 100 mg/ml doses, with 2 mg of THC per serving.

9. Royal CBD

Royal CBD’s commitment to quality is pretty straightforward. As their slogan states: “no room for mediocrity,” it’s evident that they take their products seriously. Despite the rather intense tone, it offers a sense of reassurance. Their commitment to quality is transparent, with CO2 extraction, natural sourcing, and third-party tests integral to their business.
Royal CBD offers decently potent oils. At up to 83 mg/ml in broad-spectrum and full-spectrum CBD options, they sit in the upper tiers but don’t approach the solid 100 mg/ml of CoBo, or cbdMD’s 250 mg/ml concentration.

Royal CBD’s 1,000 mg Full-Spectrum CBD Oil is a good balance between price and potency – although, at $129.00, it’s a bit expensive. Still, the product contains 33 mg/ml of CBD, an excellent mid-sized dose.

10. Green Roads

Green Roads may not have the same chops as some bigger names, but it makes up for that with its experience, knowledge, and exciting backstory.

Founded in 2013 by pharmacist Laura Fuentes, she was inspired to enter the industry after a friend with health issues approached her for help. What started as a side gig formulating products in her spare time soon became the thriving business we see today.

Green Roads carries isolate, broad-spectrum, and full-spectrum tinctures. We recommend Green Roads 1500mg Broad Spectrum CBD Oil, which contains a solid 50 mg/ml of CBD.

How We Chose the Best CBD Oil for Arthritis

Whether you’re looking for arthritis pain or other chronic pain management, you need the best CBD products. But sorting through the sea of companies is challenging and time-consuming – so we did that for you.

To remain objective, our rankings are based on a specific set of criteria, which determines a CBD vendor’s rank on our list.

Company Reputation

An easy way to find the best CBD companies is through company reputation. It’s easy for any CBD retailer to say they’re the best or post reviews on their websites. However, we avoid potentially biased sources and instead focus on independent forums, like Reddit or Trustpilot.

That being said, some companies – while excellent – are still building a place in the market, so company reputation doesn’t carry the same weight as some of our other benchmarks.

Third-Party Lab Reports

Third-party lab reports are necessary for a CBD retailer to make it anywhere near our list. These tests are critical for transparency and safety. Without concrete proof, any vendor can assure us of their products’ quality, accuracy, and purity.

Lab reports should be clear, easy to read, and from a reputable third-party lab. Some vendors do their in-house testing, but that’s a recipe for bias. The tester’s information is supposed to be listed on the test document, making it easy to check with a simple Google search.

Product Testing

Product testing is tied to third-party lab reports. Lab reports won’t exist without a testing process – unless they’re forged, which sadly has been known to happen. Like reports, testing is an absolute must-have. Hemp extracts can contain any number of contaminants, like bacteria, fungi, and heavy metals. It’s also impossible to confirm CBD content without testing the extract first.
Any vendor that doesn’t test its products should be avoided.

Customer Reviews

While company reputation focuses on brand recognition through customer volume, customer reviews determine whether a vendor—known or obscure—is worth supporting. Again, we base our evaluations on independent feedback from sources like Reddit or other consumer review forums.

Although we understand every company has its share of bad ratings, a large customer base and overwhelmingly positive responses indicate a reputable business.

CBD Oil for Arthritis FAQs

How much CBD oil to take for arthritis?

The amount of CBD oil to take for arthritis is tricky to determine. Conventional medications receive extensive study and are designed to behave a certain way, making dosing easy and predictable.
CBD, however, hasn’t had the same level of research as any medicine you’ll find at your local drugstore – prescription or otherwise. And the information we do have only indicates that textbook CBD dosing is all but impossible.
Many factors affect the correct dose, including:
● Age
● Sex
● Weight
● Tolerance
● Sensitivity (to CBD)

Our endocannabinoid systems are also unique to each of us, further complicating the dosing issue.

Start Low and Go Slow

CBD is biphasic, meaning that too much CBD is just as ineffective as taking too little. That’s why it’s essential to follow the old cannabis adage, “start low and go slow.” If you’ve never experienced CBD before, start with the smallest dose possible – around 2.5 to 5 mg. Increase that dose gradually over several days until you notice results.

When is the best time to take CBD oil for arthritis?

If you suffer from constant flare-ups, your goal will be to keep a steady supply of CBD in your body to hopefully mitigate the pain and inflammation. There’s no right or wrong time to take CBD, but consumers find it works better when taken with food.

Eating something fatty, like peanut butter, also helps speed up absorption since CBD (like all cannabinoids) needs some kind of lipid to carry it.

What is the best way to take CBD for arthritis?

The best way to take CBD for arthritis is through oral ingestion. This approach allows CBD to provide a more generalized anti-inflammatory and analgesic effect. Oils aren’t the only option. Many CBD edibles are available that make taking CBD easier for those who aren’t fans of the “hempy” oil flavor. To that end, CBD gummies are a fantastic alternative.

If you want the best CBD gummies for pain, keep our benchmarks in mind while shopping around. However, topicals are also a practical option for fast, focal relief of joint pain and inflammation. Although they’re not as long-lasting as CBD oil, topicals work almost instantly, right where you need them.

Both oils and topicals are excellent products, but using them together is the best way to prevent arthritis symptoms and quickly address them should they arise.

Does CBD have side effects?

Yes, CBD has side effects. Fortunately, they’re rare and relatively mild. Some examples include:
● Drowsiness
● Appetite change
● Diarrhea
● Mood changes

One concern is CBD’s potential interaction with certain prescription medications, such as antiepileptic drugs (AEDs). If you’re on any medicines, speak to your doctor or specialist before trying CBD.

Conclusion: Best CBD Oils for Arthritis of 2022

It’s tough to find the best CBD oils for arthritis. Shopping for the right one can be overwhelming with so many products, brands, and sources. The easiest way is to look for specific indicators of quality, credibility, and safety.

But the world of cannabinoid hemp supplements is rapidly expanding. CBD laid the groundwork, which has since paved the way for other related products. Cannabigerol (CBG) several brands—like those above—created some of the best CBG oil available, which could further help mitigate arthritis symptoms.

While there’s no guarantee CBD will work for you, being a smart shopper increases your chances of seeing positive results.

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Best CBD Oil for Arthritis: Benefits & Uses for Rheumatoid Arthritis

As many as 54 million Americans are diagnosed with arthritis every year. According to NHIS data, it’s the leading cause of work disability leave in the United States.

Arthritis can be a real pain — literally and figuratively. The disorder often brings a lowered quality of life for those affected, forces people to take time off work, and makes it difficult to exercise and remain in good shape. Many people are therefore looking for an effective form of pain management to help with the disorder.

One of the most popular arthritis-supportive supplements being used today is cannabidiol (CBD) — one of the primary active ingredients in the cannabis plant.

Can CBD really help with arthritis? What’s the best CBD oil for arthritis?

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We’ll explore these questions in detail in the article below. I’ll give you my top 5 CBD oils for arthritis pain, and give you some valuable insight into how to choose the best CBD oils for the job on your own.

This is a big topic so let’s dig in.

Best CBD Oils for Arthritis: Our Top 5 Brands of 2022

If you’re reading this article, you’re probably interested in finding a CBD product that can help you with your arthritis symptoms.

For those of you who want to understand how CBD works for arthritis, and what else you can do to make the effects of CBD even better, keep reading the sections below. If you’re simply looking for the best CBD oil to take, here’s a list of my top five CBD oils — including a breakdown of why I think it’s such a strong option.

Let’s dig into the list.

1. Royal CBD (Most Potent)

Get 15% off all Royal CBD products. Use code “CFAH” at checkout.

Technical Details:
Total CBD Content 250 – 2500 mg
Available Flavors Natural, Peppermint, Vanilla, Berry
Potency 8.3 – 83.3 mg/mL
What We Like About Royal CBD Oil:

A newcomer to the scene, Royal CBD is a premium manufacturer opting for high-grade organic ingredients in all its CBD products — including this full-spectrum hemp oil. The company’s product range is pretty simple, featuring only CBD oil, capsules, gummies, and some CBD-infused topicals.

The oil and capsules are full-spectrum extracts, while the gummies are made with a 99% pure CBD isolate. This oil has a few different options — you can choose between flavors like mint, berry, vanilla, or unflavored, and three separate potencies — 250 mg, 500 mg, 1000 mg, and 2500 mg of CBD per 30 milliliters (1 ounce) bottle. The strongest option carries 83.3mg of CBD in each milliliter.

For the best value, I recommend you aim for the higher potency option. This product has a higher initial cost than the others, but comes at a slight discount and will last a very long time — even if you use CBD on a daily basis. Only a few drops are needed to get a healthy dose of CBD.

If you don’t like the taste of natural CBD oil you can get their capsules instead. These come in an easy-to-swallow soft gel form and contain 25 mg per capsule.

All Royal CBD products are tested in third-party laboratories to ensure each batch is clean, has consistent levels of CBD, and is free from any potential contaminants.

  • Made with organic Colorado-grown hemp
  • All products are made with supercritical CO2 extraction
  • You can buy both full-spectrum and CBD isolate products
  • The highest potency bottle delivers 83.3 mg/mL
  • Every batch of product has been tested by a third-party laboratories
  • These products are priced on the higher end, although well justified

2. Gold Bee (Best Organic Formula)

Pros:
  • Made from US-grown, organic hemp
  • Contains full-spectrum CBD
  • 1200 mg of CBD per bottle (40 mg/mL)
  • Extracted with supercritical CO2
  • Delicious Kiwi flavor
  • Sweetened with organic honey
  • Third-party tested for cannabinoid content and purity
Cons:
  • Only one concentration available
  • Limited flavor options
What We Like About Royal CBD Oil:

When it comes to arthritis, the quality of ingredients is paramount, as any pro-inflammatory compound can actually worsen your symptoms. With Gold Bee, this isn’t a problem, as the brand sells all-organic CBD oils formulated with full-spectrum hemp extracts. The hemp used by the company comes from organic farms in Colorado and is gently extracted with supercritical CO2 to provide the highest purity and consistent potency.

The full-spectrum of cannabinoids means you’re getting the synergistic effects from all naturally-occurring compounds in hemp, including the supportive cannabinoids and terpenes. As a result, you need less CBD to achieve the desired results than you would with CBD isolate. The Gold Bee CBD oil packs 1200 mg of CBD in a 30-mL bottle, translating into 40 mg of CBD daily. The dosage fits within the most common range for daily use.

Gold Bee also doesn’t use artificial flavorings and sweeteners in its products. The kiwi version of the CBD oil is infused with natural terpenes and sweetened with organic honey from Brazillian rainforests. The entire Gold Bee product line is rigorously tested in third-party laboratories for potency and purity.

3. CBDPure

Technical Details:
Total CBD Content 100 – 600 mg
Available Flavors None
Potency 1.6 – 10 mg/mL
What We Like About CBDPure Hemp Oil:

CBDPure was founded in 2016 by cannabis aficionados from Colorado. The company has a simple mission — to make high-quality CBD oils made from organic hemp.

Although the company only sells CBD oil and capsules, it’s perfected both of these products. These extracts are made with supercritical CO2 and tested in third-party laboratories for quality assurance.

When it comes to CBDPure hemp oil, it isn’t as potent as those offered by Royal CBD — so if you’re looking for something high potency CBDPure may not be the best option available. However, if you want something cheap that maintains a high level of quality — CBDPure is an excellent choice.

CBDPure has an incredible return policy — which suggests the founders truly stand by their products. If you don’t like the product you can return it for 100% money back within 90 days. Most other CBD companies only offer this deal for 14 or 30 days, so this says a lot about the integrity of CBDPure as a company.

  • CBDPure products are sourced from organic hemp grown in Colorado
  • The company uses supercritical CO2 to make its extracts
  • 100% Satisfaction Guaranteed program (full refund within 90 days)
  • Narrow product range
  • The oil is slightly less potent than Royal CBD

4. Hemp Bombs

Technical Details:
Total CBD Content 300 – 5000 mg
Available Flavors Unflavored, Acai Berry, Orange Creamsicle, Peppermint, Watermelon
Potency 10 – 1166.6 mg/mL
What We Like About Hemp Bombs:

Hemp Bombs are one of the longest-standing companies in the CBD space. They’ve been around for years now, dating back before the CBD boom. As a result, the company has had a chance to become well-established in the industry, and have a loyal customer base as a result.

Although the branding makes these oils resemble a gas station brand of an energy drink — the oil contained inside is nothing to scoff at.

Hemp Bombs is able to use its large presence in the industry to source some of the best hemps in the country. They process all the hemp within the United States in GMP-certified labs. The company chose to use a CBD isolate for this oil rather than a full-spectrum extract. Using CBD isolate is cheaper and more accurate than full-spectrum products, but lacks the synergistic benefits of the entire cannabinoid and terpene profile — a concept referred to as the entourage effects.

The real benefit of using a CBD isolate is that this is the only way to guarantee the product contains no THC — which is the psychoactive cannabinoid responsible for producing the high from marijuana plants.

Hemp Bombs, like the others on this list, conducts extensive third-party testing on every batch of hemp extract that comes out of its facilities. This is the only way to ensure complete transparency and build trust with consumers. Hemp Bombs publishes these test results on the website for anybody to see — and includes the entire gamut of testing (heavy metals, cannabinoid profile, residual solvents, and microbial contaminant testing).

  • Made from high-grade CBD distillate
  • Comes in all different flavors and potencies
  • Third-party tested for transparency
  • Lacks the benefits of the entourage effect
  • Flavored with synthetic flavoring agents

5. Nuleaf Naturals

Technical Details:
Total CBD Content 240 – 4850 mg
Available Flavors None
Potency 48.5 mg/mL
What I Like About Nuleaf Naturals:

Nuleaf Naturals has the simplest product lineup I’ve ever seen. The company only offers one oil — a 48 mg/mL full-spectrum hemp extract. They use this same oil for every product offering.

When you go to the company website, you’ll find you can buy this oil in all different bottle sizes — but the oil itself is exactly the same. Even the pet oil options the company sells use this exact same extract.

The benefit of using just one oil is that Nuleaf Naturals can put all their attention and energy into this one product — doing everything they can to make it as top-notch as possible. And that’s exactly what they’ve done.

This oil is one of the best tastings and has some incredibly powerful effects compared to many of the other oils I’ve tried.

In order to even qualify for my top 5 list, the company has to offer third-party testing. I can’t trust the test results from a company doing their own testing. Nuleaf Naturals remains up to date with ordering third-party tests for every batch produced by the company. You’ll find a new test uploaded to the company website every two or three months as they release new batches of products. I have a look at these tests every time I order a bottle and have yet to find anything that stands out.

Every test I’ve seen from Nuleaf Naturals proves the oil is free from contaminants like heavy metals or pesticides, and the potency is almost always exactly the advertised potency. Occasionally a batch will come out that’s 2-5% off the advertised amount — which is expected for full-spectrum extracts.

  • Simple product lineup
  • Offers oils for both humans and pets
  • CBD oil comes in all different bottle sizes to support any budget
  • No flavor options available
  • All products use the same hemp oil

6. Medterra

Technical Details:
Total CBD Content 1000 – 2000 mg
Available Flavors Citrus
Potency 33.3 – 66.6 mg/mL
What I Like About Medterra:

This is a new product offered by the CBD giant Medterra. This company specializes in making broad-spectrum hemp extracts. This means the oil contains CBD, and most of the other supplemental cannabinoids like CBC, CBG, CBN, and THCV — but all traces of the psychoactive THC have been removed.

Medterra is intimately involved in the cultivation process for the hemp they use to make this oil — which allows the company to control the amount of pesticide used, and the timing of the harvest. These factors play a big role in the overall quality of the oil. Most other CBD companies buy hemp from farms located around the United States or Canada and have little control over the growing process.

Like any high-end CBD oil, this product has been thoroughly tested by both Medterras analysis lab, and independent laboratories.

Medterra sells a lot more than just CBD oils — you can also buy topicals, capsules, and pet treats.

  • Medterra has complete control of the entire manufacturing process from seed to bottle
  • Extensive third-party testing
  • Broad-spectrum THC-free hemp oil
  • Limited bottle sizes and flavor options
  • This oil is heavily processed

What is Arthritis?

Arthritis is one of the most common causes of disability in the United States. Millions of people in the United States alone suffer from debilitating joint pain and inflammation from arthritis.

The disease causes severe inflammation and pain, as well as swelling and loss of function in the joints.

There are two main types of arthritis:

  1. Rheumatoid arthritis — This form of arthritis is an autoimmune disease. This means that the cause of inflammation is triggered by our own immune systems. White blood cells mistakenly attack and destroy our own joint tissue, causing a cascade of inflammatory processes in the joints — causing them to swell up and feel hot and sore. This form of arthritis can affect any joint but tends to focus on the larger joints such as the knee, hips, elbows, and knuckles.
  2. Osteoarthritis — This form of arthritis is caused by physical trauma and wear and tear rather than the immune system. This form of arthritis is common in athletes and older people. The condition begins with a low-grade inflammation in the joint itself, which causes the degeneration of protective cartilage and synovial fluid (lubrication for the joints). As the joint tissue becomes damaged, inflammation and pain worsen and reduce the mobility of the joint. This condition is degenerative — which means it tends to worsen over time.

All forms of arthritis have the same basic symptoms — pain, inflammation, and reduced mobility of one or more joints. Despite having radically different underlying causes, CBD has become extremely popular among arthritis sufferers in recent years.

CBD Oil & Arthritis: Can it Help?

Let’s explore how CBD works, and why it’s become so popular among arthritis patients.

CBD is one of the active ingredients in hemp plants (Cannabis sativa). This phytochemical is completely non-psychoactive, which means it won’t cause the user to feel high. A related cannabinoid (THC) not found in high amounts in hemp plants is what causes marijuana users to feel high.

When CBD enters your bloodstream, it interacts with the endocannabinoid system — a complex neurochemical network responsible for maintaining various homeostatic functions in the body. This includes pain perception, immune response, temperature control, memory, mood, hunger, fertility, inflammation, and much more.

While research on CBD and arthritis is in the early stage, current evidence coming from animal studies and several human trials suggests it may alleviate the symptoms of arthritis while resulting in virtually no side effects.

Animal Studies on CBD & Arthritis

  1. A 2011 study discovered that CBD was able to reduce inflammatory pain in rats by changing the way pain receptors react to stimuli.
  2. A 2014 review of the existing animal-based studies concluded that CBD may be effective for relieving osteoarthritis.
  3. In a 2016 study, researchers found that CBD may relieve inflammation linked to arthritis in problematic areas when applied topically.
  4. A 2017 research paper suggested that CBD was a safe and effective treatment option for osteoarthritis joint pain.

The big question is whether these results can be replicated in actual human trials. Interestingly, this seems to be the case!

Clinical Trials on CBD & Arthritis

  1. In 2006, the first study on cannabinoids and rheumatoid arthritis concluded that a pharmaceutical CBD-enriched cannabis extract called Sativex had a “significant analgesic effect” in arthritis patients. Researchers reported that pain and inflammation were significantly reduced throughout the treatment despite having almost no reported side effects.
  2. A 2008 study involving cannabinoids in the management of chronic pain discovered that CBD offered effective pain relief and improved sleep quality in the test group.
  3. A 2016 analysis of human trials for rheumatoid arthritis, osteoarthritis, and fibromyalgia also found that CBD resulted in a reduction in joint pain and improvement in irregular sleep patterns caused by chronic pain.

CBD Oil For Sale: Where To Find High-Grade CBD Oil

Most people look for CBD oils online — myself included. Don’t get me wrong, it’s possible to find high-quality CBD oil in a local dispensary, but I’ve found online to offer a greater range of products, and quite frankly, better prices.

I recommend you check out the company websites listed in the section at the top of this article, or do your own research using the tips listed in the section below to find other reputable CBD brands online. Read reviews, and look for third-party testing before you buy the product to make sure it’s going to deliver on its promises.

Must-Know Details for People Buying CBD Oil for Arthritis

Knowing what to look for in the best CBD oil for arthritis will save you a lot of hassle — there are a lot of fly-by-night companies currently offering CBD oils with questionable quality, to say the least.

CBD is an emerging market, so it’s no wonder many companies want to capitalize on the booming trend before the dust settles and the industry stabilizes.

With such an abundance of different brands selling CBD in various forms, it’s important to find a trusted manufacturer who will ensure high standards for their products.

Here’s what you should pay attention to when shopping for CBD oil to help with your arthritis symptoms.

1. Hemp Source: Where is the Hemp Sourced?

Hemp plants are unique in that they will absorb and accumulate virtually any and all elements in the soil and air in which it’s grown — this includes both the good stuff and the bad stuff.

Plants grown in contaminated soils will often contain harmful levels of heavy metals like cadmium, lead, or mercury. For this reason, it’s important you look for products that have been grown in regions with little contamination — such as America or Canada.

Some companies source cheap hemp from India or China to cut costs — which are notoriously high in toxic heavy metal contaminants.

I prefer oils made from American-grown hemp because of the high standards here that prevent farmers from growing food or supplementing crops in contaminated soils or polluted air.

The best hemp comes from USDA-certified organic farms — but these are hard to come by at the moment.

2. Extraction Method: Did The Company Use Toxic Solvents to Make the Oil?

Most reputable companies use CO2 for making their CBD oil. Pressurized CO2 works as a solvent that pulls CBD and other compounds from the plant material. When the pressure is released, the CO2 evaporates completely, leaving no trace of harmful chemical solvents in the final product.

This is in opposition to the conventional extraction methods — which use toxic solvents to strip the cannabinoids from the plant material such as hexane, propane, butane, or ether. If these solvents are used they need to be evaporated out. Oftentimes, small amounts of these chemicals will remain in the final product which can cause many unwanted side effects to people using the oil.

3. Cannabinoid Spectrum: Could There be any THC in the Final Product?

The next thing to look at is the cannabinoid profile of the oil. This refers to the amount of CBD and other cannabinoids in the final product.

There are three main categories here:

  1. Full-spectrum extracts — these oils contain many different cannabinoids aside from just CBD
  2. Broad-spectrum extracts — these oils contain many cannabinoids with the exception of THC
  3. CBD isolates — these oils contain only one cannabinoid — CBD

Many experts argue that full-spectrum CBD oil is better for arthritis-related inflammation. A 2016 Israeli study found that unlike pure CBD isolate, full-spectrum extracts offered more reliable benefits for arthritis sufferers. However, there are benefits to using broad-spectrum or isolate-based products as well.

4. Route of Administration: How is the Oil Intended to be Used?

CBD comes in a few different forms and can be used in several different ways:

  1. Sublingual — placed under the tongue for fast absorption
  2. Edibles — helps mask the flavor of hemp oil bit has a slower onset of effects
  3. Vape liquids — used in vape pens to inhale the CBD for absorption via the lungs
  4. Topicals — applied directly to the skin for localized relief

Generally, the best CBD products for arthritis are going to be a combination of topical CBD and oral CBD. I rub CBD-infused joint cream on the affected area first and then use CBD oil sublingually for the fastest onset of effects. I know a few other people that prefer to use a CBD-infused vape pen and CBD topicals to relieve arthritis.

5. Third-Party Testing: Does the Company Provide Transparency for its Claims?

Every company has the option to send a batch of their product to a third-party laboratory for content analysis. In order to be considered a third-party lab, it needs to have no affiliation with the manufacturer — allowing for a completely unbiased assessment of the products in question.

These laboratories measure the potency of CBD, scan the entire cannabinoid profile of the product, and can detect over 200 common contaminants.

This form of testing offers transparency on the quality and potency of the product. If you can’t find third-party testing to confirm the CBD oil you’re looking at contains exactly what the company says it does — I recommend you look elsewhere until you find a company that publishes this data publicly. It’s the only way to ensure the product you’re buying is going to be safe and effective.

What’s the Ideal CBD Dosage for Arthritis?

There is actually no one-size-fits-all dosage of cannabidiol when it comes to inflammatory pain caused by arthritis. The dose will vary a lot from one person to the next.

However, information gathered from CBD users suggests that most arthritis sufferers take around 25 mg of CBD in the form of an oil twice a day. You may need to increase or decrease this dose depending on how you respond to the oil. Most people shouldn’t expect any improvement in the first couple of days.

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If you don’t feel any difference, gradually increase the amount of CBD oil until you find an effective dose.

Final Thoughts on Using CBD Oil for Arthritis

So far, research investigating the benefits of CBD oil for arthritis shows promising results. More research is needed to fully understand the role CBD and other cannabinoids play in alleviating arthritis-related pain and inflammation.

Although a large share of the studies currently available come from animal models. There are only a handful of good-quality clinical trials (double-blind and randomized). Of the few we have available in the scientific literature, all have shown notably positive results from the treatment group using CBD rather than placebo.

With all that said, it’s important to remember that CBD isn’t an overnight fix to all your problems, and in more serious cases, it may need some time to make the impact you’re looking for.

If you’re planning to use CBD oil for arthritis, consult your doctor first to discuss any potential interactions with other underlying health conditions or medications you may be taking.

Have you used CBD oil for arthritis symptoms? Post your results in the comment section below!

References:

  1. Schuelert, N. & Mcdougall, J.J. (2011). the Abnormal Cannabidiol Analogue O-1602 Reduces Nociception in a Rat Model of Acute Arthritis Via the Putative Cannabinoid Receptor Gpr55., Neuroscience Letters, 500(1), 72–76.
  2. La Porta, C., Bura, S.A., Negrete, R., Maldonado, R. (2014). Involvement of the Endocannabinoid System in Osteoarthritis Pain. The European Journal of Neuroscience, 39(3), 485–500.
  3. Philippot, H.T., O’Brien, M., McDougall, J.J. (2017). Attenuation of Early Phase Inflammation By Cannabidiol Prevents Pain and Nerve Damage in Rat Osteoarthritis. Pain, 158(12), 2442–2451.
  4. Blake, D.R., Robson, P., Ho, M., Jubb, R.W., McCabe, C.S. (2006) Preliminary Assessment of the Efficacy, Tolerability and Safety of a Cannabis-based Medicine (Sativex) in the Treatment of Pain Caused by Rheumatoid Arthritis. Rheumatology (Oxford), 45(1), 50–52.
  5. Russo E. B. (2008). Cannabinoids in the Management of Difficult to Treat Pain. Therapeutics and Clinical Risk Management, 4(1), 245–259.
  6. Fitzcharles, M.A., Baerwald, C., Ablin, J., Hauser, W. (2016). Efficacy, Tolerability and Safety of Cannabinoids in Chronic Pain Associated With Rheumatic Diseases (fibromyalgia Syndrome, Back Pain, Osteoarthritis, Rheumatoid Arthritis): a Systematic Review of Randomized Controlled Trials. Schmerz (Berlin, Germany), 30(1), 47–61.
  7. Gallily, R., Yekhtin, Z., Lumir, O.H. (2015). Overcoming the Bell-Shaped Dose-Response of Cannabidiol by Using Cannabis Extract Enriched in Cannabidiol. Pharmacology & Pharmacy, 6, 75–85.
Nina Julia

Nina created CFAH.org following the birth of her second child. She was a science and math teacher for 6 years prior to becoming a parent — teaching in schools in White Plains, New York and later in Paterson, New Jersey.

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Best CBD Oil for Pain Relief & Inflammation: Highest Quality Brands On The Market

Over the past three years, CBD oil has become increasingly popular as a health and wellness supplement.

One of the main reasons people are interested in trying CBD oil is because of its pain-killing benefits. We’ll get into the details of how CBD is suggested to help with pain later, along with some suggestions for the best CBD oils for pain and inflammation.

The ability for CBD to help with pain is a significant advantage over conventional pain management options — which often involve addictive and potentially harmful medications. Instead, this natural supplement has very few side effects and an exceptional safety profile — all without compromising on effectiveness.

But how do you choose the right CBD oil for the job?

This is an important question to ask because the truth of the matter is that not all CBD oils work. Many simply contain too little CBD to be of any help, while others contain harmful contaminants like heavy metals, pesticides, or chemical solvents — all of which could add to the pain you’re already experiencing by damaging the sensitive nerve cells around the body.

We’re going to cover all of this in the article below. You’ll learn how to spot a high-quality CBD oil and how current evidence shows CBD to work inside the body.

This is a big topic, so let’s get started with our list of top-rated CBD oils for pain.

Top 10 Best CBD Oil Brands for Pain Management in 2022

Not sure which CBD oil to buy to help with chronic pain? Before we get into the nitty-gritty of how CBD is suggested to work for pain and inflammation, here’s our top 5 list of CBD oils I’ve used myself for back pain.

We’ll also offer some advice on a few ways you can spot a trustworthy CBD vendor even if they didn’t quite make it onto our list.

I’ve been using CBD for over 5 years now and I’ve stumbled upon some stellar companies with top-notch oils and fly-by-night businesses with oils that can’t simply don’t work.

I have a relatively short list of CBD brands that I fully trust and I want to share my choices with you so you can avoid some of the headaches and disappointment I’ve already endured.

Here are my top 10 CBD oil brands for pain:

1. Royal CBD (Best CBD Oil On The Market)

Technical Details
Total CBD Content 250 – 2500 mg
Available Flavors Natural, Mint, Vanilla, Berry
Potency 8.3 – 83.3 mg/mL

Get 15% off all Royal CBD products. Use code “CFAH” at checkout.

Why Royal CBD is My Top Pick:

As skeptical as I am towards the majority of new CBD brands, I decided to give Royal CBD a try because I liked the company’s dedication to quality. I love seeing companies that take what they do seriously.

You can tell right away from the color, flavor, and consistency of the oil that you’re dealing with a product well above average.

This oil is cheaper than most of the other premium CBD oils I’ve tried, comes in a full range of potencies, and uses some of the best full-spectrum hemp extracts I’ve ever seen. I’ve heard friends using this brand for quite some time and decided to give it a try for myself — so I ordered a few bottles in different strengths.

After taking the Royal CBD’s 2500mg full-spectrum CBD oil for just over a week, I noticed an improvement in my back pain. There was a time when I had serious problems falling asleep because of the sharp pains in my back that seemed to intensify whenever I laid down to fall asleep. It was a nightmare. I’d lay awake for hours changing positions to try and find a spot that didn’t leave me writhing in discomfort.

With this oil, my experience went far beyond what I expected. Not only did it help ease the pain, but my overall quality of sleep improved. I mean, I didn’t sleep longer but I began to wake up rested and with a clear head.

My favorite combination for this particular oil is the vanilla in the 1000 mg bottle. This is the largest potency option currently offered by Royal CBD and has the best value overall. I took the oil twice per day, once in the morning when I woke up, and again in the evening before bed. One bottle of the 1000 mg CBD oil lasted me about a month.

  • Sourced from US-grown organic hemp
  • Extracted with supercritical CO2
  • Contains the full spectrum of cannabinoids and terpenes
  • Available in 4 different strengths
  • Up to 2500mg of CBD per bottle
  • Lab-tested for potency and purity
  • Great natural flavors (no aftertaste and comes in multiple flavor options)
  • Free shipping within the USA
  • Newer brand on the market that only sells online, no physical presence

2. Gold Bee (Best Organic CBD Oil)

  • Premium Colorado-grown hemp
  • CO2 extraction
  • Contains full-spectrum CBD
  • Delicious kiwi flavor
  • Sweetened with organic honey
  • Lab-tested for potency and purity
  • Only one flavored option available
  • No high-strength oils (yet)

What I Like About Gold Bee:

I honestly believe Gold Bee makes the best organic CBD products out there. The brand combines premium Colorado-grown hemp with organic honey sourced from the Brazillian Rainforest. While Gold Bee offers a modest selection of oils — with up to 1200 mg of CBD per bottle — the formula is spot-on when it comes to the quality of ingredients. I’m totally not going to complain about the potency, as my back pain and sleep quality got better than with some high-strength oils I’ve tried in the past. Considering the quality of these products, they actually come at a bargain price. If you want to try other formats from Gold Bee, you can choose between its high-strength capsules and CBD-infused honey.

3. CBDPure (Runner Up)

Technical Details
Total CBD Content 100 – 600 mg
Available Flavors None
Potency 1.6 – 10 mg/mL
What I Like About CBDPure CBD Oil:

I love how transparent this company is. If I were judging companies solely by their transparency level, CBDPure would have scored the second place, right after Royal CBD. The company provides all the details about each stage of production when making this CBD oil. You can find all the third-party lab test results for each batch on the product page — something we’ve come to expect from any high-quality CBD company.

What really makes this company stand out is its incredible satisfaction guarantee. If you order the product and decide it wasn’t working for you, simply send it back and get a full refund. This satisfaction guarantee extends over 3 whole months — which is about three times longer than the industry average.

I keep a bottle or two of CBDPure oil in my medicine cabinet for achy moments after a run or hike with the kids.

The only real downside to this oil is the potency — which comes in denominations of 1.5, 5, and 10 mg/mL. This is suitable for more minor symptoms, but may not be enough for people with heavy CBD demands.

  • Sourced from Colorado-grown organic hemp
  • Extracted with supercritical CO2
  • Tested for the cannabinoid content and purity in a third-party lab
  • Rock-solid 90-day return policy
  • Narrow product range
  • Low potency
  • They don’t ship to every state (i.e. Louisiana, Indiana, Arkansas, Kansas)

4. HempBombs

Technical Details
Total CBD Content 300 – 4000 mg
Available Flavors Unflavored, Acai Berry, Orange Creamsicle, Peppermint, Watermelon
Potency 10 – 133.3 mg/mL
What I Like About HempBombs:

I used HempBombs CBD isolate-based hemp oil for quite some time before switching to full-spectrum CBD oil and in my opinion, this is the best brand when it comes to CBD isolates. Their products contain 99% pure CBD and ZERO THC.

Now don’t get me wrong, CBD isolates are great, they offer consistent doses of CBD, contain 0% THC, and are generally cheaper than their full-spectrum counterparts. In most cases, I like using a full-spectrum extract like Royal CBD oil because of something called the entourage effect — which is a concept highlighting the phenomenon where cannabinoids like CBD tend to work better when other hemp-derived compounds are also present.

In isolates, the only cannabinoid present is CBD.

HempBombs CBD oil is available in five different strengths — from 300mg to 4000mg per bottle. The CBD is added in the form of a 99% pure isolate — which means there’s going to be virtually no traceable amounts of any other cannabinoids, including THC, CBC, CBG, or CBN.

You can also buy these oils in different flavors. Hemp Bombs often adds new flavors to the list, but my all-time personal favorite is the Acai berry. It’s not too sweet but adds a really pleasant flavor to the otherwise bland CBD and MCT oil formula.

  • Sourced from 100% certified organic hemp from European farms
  • Extracted with supercritical CO2
  • Completely THC-free
  • Tested in third-party laboratories for purity and potency
  • Available in 5 separate strengths
  • Up to 4000mg of CBD per bottle
  • Lacks the synergistic effects from other cannabinoids
  • The highest potencies are overkill for most users
  • Uses synthetic flavoring agents

5. CBDistillery

Technical Details
Total CBD Content 250 – 5000 mg
Available Flavors None
Potency 8.3 – 166 mg/mL
What I Like About CBDistillery:

CBDistillery is now one of the largest CBD companies in North America. The company began in 2016 as a legacy brand for Balanced Health Botanicals.

Over the years, CBDistillery has had the chance to really dial-in its CBD oil formula. The company now sells its CBD oil in two formats — “full-spectrum” and “THC-free.” The THC-free option is great for people who want to benefit from the synergy of CBD and other cannabinoids but without bringing any THC whatsoever into their system.

Even the full-spectrum option contains less than 0.3% THC — which is well below the amount needed to cause any psychoactive effects. These oils are both completely non-psychoactive.

You can choose between five different strengths, starting at 250mg up to 5000mg of CBD per bottle. This covers just about every range of potencies you would ever need. We recommend opting for the higher potency options because they have the best value overall. The higher potency you purchase, the further your dollar gets you.

The more potent options also las the longest because you need smaller amounts of the oil each time to get the desired dose of CBD.

I tried the 1000mg bottle to keep myself calm during the first few months after giving birth to my first son and I must admit it helped me maintain my sanity during that time. I found it to have a remarkable calming effect on the body and mind.

  • Available as full-spectrum CBD or pure CBD oil (THC-free)
  • 5 strengths to choose from
  • Carries up to 33.3 mg of CBD per mL (in the 1000 mg bottle)
  • Excellent value CBD oil
  • The hemp isn’t certified organic
  • No flavor options available
  • The company website is clunky and hard to navigate

6. NuLeaf Naturals

Technical Details
Total CBD Content 240 – 4850 mg
Available Flavors None
Potency 48.5 mg/mL
What I Like About NuLeaf Naturals

Nuleaf Naturals is one of the most popular CBD companies in the United States — most likely related to how long the company has been in the business of selling CBD. Nuleaf naturals were one of the first CBD companies to enter the mainstream market.

Despite the companies longstanding reputation, Nuleaf Naturals only sells one CBD oil. When you go to the website you’ll find a few different options, including a pet oil — but it’s important to understand that these are all the exact same full-spectrum extract, the only difference is the bottle sizes.

We love the simplicity of Nuleaf Naturals product lineup. The oils come with a decent potency of around 48 mg/mL, and just about every bottle size you can imagine. This makes it easy for everybody to find a product that works for them regardless of the budget.

With that said, if you have the cash, we highly recommend getting the larger bottle sizes in order to get the best value for your money.

You can choose between five different sizes:

  • Sourced from organic Colorado-grown hemp
  • Extracted using supercritical CO2
  • Made from a full-spectrum hemp extract
  • More expensive than the other brands in this ranking
  • Narrow product range

7. Charlotte’s Web

Technical Details
Total CBD Content 200 – 1800 mg
Available Flavors Mint Chocolate, Lemon Twist, Orange Blossom, Olive Oil
Potency 7 – 60 mg/mL

About Charlotte’s Web:

Charlotte’s Web is one of the pioneers in the American CBD industry. Established by the Stanley Brothers, the company has coined a reputation of a trustworthy manufacturer by helping now late Charlotte Figi with her treatment-resistant epilepsy. Although the company has recently received a warning letter from the FDA due to their health claims, they still have many faithful customers and a massive number of positive reviews on the web.

Charlotte’s Web CBD oil comes in several potencies: 200 mg, 500 mg, 1500 mg, and 1800 mg of CBD per bottle. The highest strength offers 60 mg of full-spectrum CBD per milliliter. There are two bottle sizes to choose from: 30 mL and 100 mL; Charlotte’s Web also has flavored variants of its CBD oil, including Lemon Twist, Orange Blossom, Mint Chocolate, and Olive Oil.

What could the company do better?

First off, they could change their extraction method because they use ethanol, which is less efficient than CO2 extraction. Secondly, and most importantly, the suspension in olive oil makes them taste a bit bitter — even in the flavored versions.

Pros:

  • One of the most reputable brands on the market
  • Full-spectrum CBD
  • Delicious flavored versions
  • Up to 1800 mg of CBD per bottle
  • Available in two sizes: 30 mL and 100 mL
  • Third-party tested for potency and purity

Cons:

  • Non-organic hemp
  • Ethanol extraction
  • Suspension in olive oil (bitter taste)
  • The company received a warning letter from the FDA in the past due to inappropriate health claims

8. cbdMD

Technical Details
Total CBD Content 300 – 7500 mg
Available Flavors Natural, Berry, Orange, Mint
Potency 10 – 250 mg/mL

About cbdMD:

cbdMD is another popular manufacturer that offers a wide range of CBD extracts, from tinctures to gummies to capsules, bath bombs, topicals, sleep aids, and pet products.

The brand offers a wide range of pure CBD oils, with up to 7500 mg of CBD per bottle. The highest potency comes with a whopping dose of 200 mg of pure CBD suspended in MCT oil for higher bioavailability and a smoother flavor. cbdMD also has three flavored CBD oils: Berry, Orange, and Mint.

Despite an impressive potency range, cbdMD uses broad-spectrum CBD in their products, which doesn’t evoke the full entourage effect. The higher potency may not necessarily mean better results in this case.

The company has high transparency standards; not only does cbdMD broadly describe their activity from farming to testing, but they also provide batch-specific certificates of analysis for their products, including the results for potency and common contaminants like pesticides, heavy metals, and residual solvents.

Pros:

  • US-grown, non-GMO hemp
  • CO2 extraction
  • THC-free
  • Up to 7500 mg of CBD per bottle
  • Batch-specific certificates of analysis

Cons:

  • Limited entourage effect due to the lack of THC
  • Most people don’t need such high doses of CBD in their routine

9. Medterra

Technical Details
Total CBD Content 500 – 3000 mg
Available Flavors Natural, Citrus, Mint Chocolate
Potency 16 – 100 mg/mL

About Medterra:

Medterra is a small craft company from California. The brand offers premium CBD oils in different spectra: full-spectrum CBD, broad-spectrum CBD, and isolates. The potency of these products ranges between 500 mg and 3000 mg of CBD per bottle, which is a standard range. On top of the unflavored version, there are two flavored options: Citrus and Chocolate

Medterra prides itself on making the real full-spectrum CBD because each bottle of its full-spectrum CBD oil comes with 2 mg of THC. However, these products are only legal in the states that have legalized higher amounts of THC for recreational use. So, if you want to buy the company’s products in all 50 states, your options are limited to broad-spectrum CBD and CBD isolate. These provide more CBD per bottle — upwards of 1000 mg.

The entire Medterra’s product range is tested in a third-party laboratory for their CBD content and safety.

Pros:

  • Premium-grade CBD oils
  • Up to 3000 mg of CBD per bottle
  • Available as full-spectrum CBD, broad-spectrum CBD, and isolates
  • Lab tested for potency and purity

Cons:

  • The “real” full-spectrum CBD oil isn’t available in all states
  • Some of the lab reports indicate higher CBD levels than stated on the bottle
  • No discounts for returning customers

10. Joy Organics

Technical Details
Total CBD Content 450 – 900 mg
Available Flavors Tranquil Mint, Fresh Lime, Summer Lemon
Potency 15 – 30 mg/mL

About Joy Organics:

Joy Organics holds the reputation of one of the most reputable CBD vendors in the industry. The company was established by a woman named Joy Smith, who has been using CBD oil to manage her problems with pain and sleep. After experiencing the benefits of CBD first-hand, she has decided to share her passion for cannabis with other health-conscious consumers.

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The brand sells a range of broad-spectrum CBD products from certified organic hemp. They have many positive reviews all over the Internet; they also haven’t received any warning letter regarding health claims from the FDA — unlike many companies in this space (even the veterans like Charlotte’s Web).

The Joy Organics CBD oil features a broad-spectrum CBD formula in a modest potency range, from 450 to 900 mg of CBD per bottle. You can choose from three refreshing flavors: Summer Lemon, Fresh Lime, and Tranquil Mint. The strongest version of the Joy Organics CBD oil contains 30 mg of broad-spectrum CBD in every milliliter, which is a standard dose for most people who take CBD oil for daily supplementation.

In 2018, one of the company’s flavored CBD oils was found to contain a fungicide that is commonly sprayed on citrus fruit during independent lab testing. Fortunately, Joy Organics recalled the product shortly after this incident and implemented a new third-party testing system to make sure there are no flaws in the end product.

Pros:

  • Non-GMO, US-grown hemp
  • Supercritical CO2 extraction
  • Broad-spectrum CBD
  • THC-free
  • Delicious flavors

Cons:

  • A bit expensive
  • No high-strength oils

CBD Oil for Pain Management: Complete Guide for Beginners

Now that we’ve covered a few CBD oil options that are going to provide the best value for your money, let’s discuss how CBD is suggested to support chronic pain in the first place. We’ll also cover some of the most common ways people are using CBD oil for pain.

What is CBD Oil?

CBD stands for cannabidiol _ it’s one of the primary active ingredients in the cannabis plant. It’s completely non-psychoactive and offers a wide range of benefits to the human body.

CBD oil is a combination of a CBD extract, with a carrier oil to help dissolve and store the CBD. Most CBD oils use carrier oils like MCT oil, or hemp seed oil — which is then combined with CBD isolate, or full-spectrum hemp extract rich in CBD and other similar cannabinoids.

Cannabinoids like CBD are fat-soluble — which means they dissolve when mixed with oil, but won’t dissolve in water. By dissolving these compounds in an oil solution, the CBD becomes much easier to store and use. Instead of measuring out micrograms of CBD crystals or hemp resin, all you need to do is measure oil to get your dose of CBD. This can be done using a simple dropper that comes standard with most CBD oils.

Because of their ease of use, and long shelf-life, CBD oils have become the go-to method of using CBD and other hemp extracts.

You can also opt-out to use CBD-infused gummies if you wanted something discreetly, read our in-depth review on CBD Gummies to understand better.

How Does CBD Work?

Cannabis has been used for managing pain and inflammation for thousands of years.

The earliest records of the medical use of the herb date back to ancient China when the emperor Shen-Nung placed it among other therapeutic substances in the Chinese pharmacopeia (1). The leaves were wrapped around an injury as a poultice to reduce pain and discomfort, and reverse swelling and bruising.

Despite being a known medicine for a long time, scientists have only recently begun to unlock the mechanisms cannabis uses to achieve its important pain-killing benefits.

Since the discovery of the endocannabinoid system in 1992, CBD and other phytocannabinoids have been in the spotlight of modern medicine.

The endocannabinoid system is one of the most important neurochemical networks in the human body (2). It works by interacting with the endocannabinoid system — a series of hormones and receptors that help regulate over a dozen core processes in the human body. The active compounds in the cannabis plant are very similar to the naturally-produced hormones involved with our endocannabinoid system.

By interacting with the endocannabinoid system, CBD and other cannabinoids are able to modulate several key processes, such as:

  • Appetite
  • Immune function
  • Memory
  • Mood
  • Stress
  • Sensory perception (including pain)
  • Inflammation
  • Reproductive health
  • Nerve function
  • Sleep

How Can CBD Reduce Pain Transmission?

How does all of this relate to pain? The answer lies in the way pain is transmitted to the brain.

When we injure ourselves, cells in the immediate vicinity begin releasing compounds that trigger a cascade of inflammation and sensory activation — which is what triggers the pain transmission.

The pain signal is then sent to the spinal cord through a network of nerves distributed all around the body.

Once in the spine, the pain signal is sent through a gateway (opioid and vanilloid receptors) designed to limit the amount of signal that ends up in the brain for processing. This works like a border crossing. The border security decides whether or not you’re allowed to enter and what you can take with you.

In the context of pain, these gateways can limit the amount of pain signal that continues across the border to the brain. If more pain signal is allowed to pass, the brain perceives more pain. If the pain is stopped at the border, the brain perceives less pain.

Conventional pain medications work by activating the opioid receptors acting as a key gateway for pain transmission to the brain.

CBD has a similar effect, but through a different receptor is known as the vanilloid receptors. These vanilloid receptors are tasked with regulating a specific form of pain caused by either heat or inflammation. CBD has been reported to modulate this vanilloid receptor — leading to a reduction in the pain signals sent to the brain from inflammatory causes such as arthritis, muscle damage, or infection, to name a few.

CBD has other ways it can limit pain transmission as well:

  • CBD may reduce inflammation, limiting the initial cause of pain in the body
  • CBD acts as an antioxidant, helping the body resist and recover from damage
  • CBD relaxes muscle fibers, reducing pain caused by muscle spasms and tightness

More research is needed to fully understand how CBD and other active cannabinoids can block pain. Every year dozens of new research papers are published in an attempt to paint a clear picture of how CBD works, how to get the most benefit from the supplement, and what its limitations are.

(Pain Transmission Pathway to the Brain)

Choosing CBD Oil Companies: How to Differentiate the Good From the Bad

CBD has become a lucrative business. Companies are selling a myriad of different CBD oils and other products in an attempt to cash in on the new health trend. This means there are a lot of excellent products coming to market, but it also means there’s a lot of trash as well. It’s important as a CBD user that you understand what makes a CBD oil good, and what makes it bad so you can avoid wasting your money, or worse — using CBD oils that contain harmful or damaging ingredients.

Let’s cover the most important points to remember when shopping for CBD oil online or in-store.

1. Check the Hemp Source

The source of the hemp used to make the oil is vitally important when it comes to determining which CBD oils are the best. The main reason comes down to the botany of the hemp plant itself.

Hemp is a bio-accumulator — which means it has the tendency to absorb compounds from the soil and accumulate them in its leaves, stems, and roots. The deep taproots of the hemp plant stretch far beneath the soil, pulling out and storing all the heavy metals and other elements it can find in the soil.

This aspect is in part why hemp is so nutritious, but it also means that plants grown in contaminated soils often contain contaminants that can be harmful to your health. Some of the worst offenders are heavy metals — which can build up in the body over time and lead to severe long-term health effects.

You want to avoid consuming heavy metals at all costs.

Poorly grown hemp could contain heavy metals, as well as other contaminants like mycotoxins, or pesticide residues that will end up in the CBD oil after all the processing is complete.

For this reason, it’s important to purchase CBD oil from companies that account for this effect. Only buy from company’s that make an effort to source hemp from organic farms, and take measures to assess every batch of hemp that enters the facility to determine heavy metal, microbial contaminant, and pesticide contamination.

The best hemp sources tend to come from states like Oregon, Colorado, or Alabama, as well as neighboring countries like Canada or Scandinavian countries. These places are all known for having high standards for hemp cultivation, and clean soils.

2. Look for CO2 Extracted Products

Once the company has the hemp, they need to extract the CBD from it. You can do this in many different ways using solvents like ethanol, methanol, hexane, ether, or butane. All of these solvents work to strip the active compounds from the hemp plant and can then be evaporated to leave behind a pure CBD-rich resin.

however, there’s a problem with these solvents.

Even in professional lab settings, it can be very difficult to remove all traces of these solvents from the final product. Most of these solvents are toxic to the human body, even in trace amounts.

Therefore, the best companies are using another method to strop the active ingredients from the starting hemp material. This method uses CO2 placed under high pressure. the high pressure and temperature control convert the CO2 into a phase that’s neither liquid nor gas. This special state is referred to as being supercritical.

Supercritical CO2 acts just like any other solvent, but with one key benefit — as soon as the pressure is relieved, the gas evaporates completely, leaving behind no harmful chemical residues.

when shopping for CBD oil, it’s ideal to look for a company that uses supercritical CO2 to extract the CBD rather than the toxic solvents mentioned above. Supercritical CO2 is very expensive and highly technical — but usually produces a far superior product in the end.

If a company is using harsh solvents like butane or propane (or they don’t tell you anything about their extraction methods), it’s a sign that you should look for another brand.

3. Ask for Third-Party Lab Reports

Every company has the option to send their products to an independent lab or third-party testing.

These laboratory tests check for the entire cannabinoid profile of the extract and are able to detect over 200 common contaminants.

Before a CBD product becomes available for sale, it should pass the laboratory test for potency and purity. If any inconsistencies are shown between different batches of the same product, the company should rework it and send it for analysis once again.

High-quality CBD companies will continually send each batch of product to a lab with no affiliation to the company (called a third-party or independent lab) for testing. These results are then published publicly on the website for customers to view.

The best companies will take this even one step further — adding a database and batch numbers on every bottle of CBD oil so you can view the results for your specific bottle of oil. Third-party testing is now an industry standard.

Always buy your CBD oil from companies that show third-party lab reports on their website. Only then will you know what’s inside the bottle before you even order a product. If the company is producing CBD oil that’s as high quality, as they say, there should be nothing to hide in these lab tests and they should be listed publicly on the company website. If you can’t find them on the site, you can ask customer service for these as well.

If these tests don’t exist, or you can’t track them down from the website or customer service — it’s best to avoid this company and move on to another that takes this important step seriously.

What the Research Says About Using CBD Oil for Pain:

Understanding how CBD works is no simple task. This compound is incredibly complex — working through a number of unrelated receptors around the body, interacting with enzymes, cell membranes, and various other cell structures. This makes studying CBD very difficult.

Nevertheless, there have been thousands of research papers published on medical marijuana — seeking to understand the interaction between cannabinoids like CBD and the human body. A lot of this research specifically focused on the effects of CBD on various forms and causes of pain. Let’s explore some of the results this research has yielded in the context of pain management.

1. CBD Oil for Chronic Back & Nerve Pain

The painkilling properties of cannabidiol have been most thoroughly studied in animal models, as well as a handful of human clinical trials.

One of the best studies we have available on the topic is a meta-analysis published in 2017. This analysis looked at 24 different clinical trials involving 1,334 patients over several years and demographics. These studies all used various forms of cannabis for treating chronic pain. The analysis reports that many of these studies showed a reduction in chronic pain scores by 50% or more (3) — suggesting the cannabis plant to be a potential treatment for chronic pain.

Another clinical trial looked at the effects of a combination of CBD to THC in the treatment of intractable cancer pain. This study found that twice as many people in the treatment group given CBD and THC had a 30% or more reduction in pain symptoms at the conclusion of the trial (6).

Even though more clinical trials on humans are needed to gauge how CBD affects specific forms of pain or other conditions, scientists believe the efficacy of CBD in treating chronic pain is related to its anti-inflammatory effects (3).

2. CBD Oil for Arthritis

CBD has had a lot of research as a potential alternative to prescription and non-prescription pain medications commonly used for alleviating arthritis pain.

Researchers have found a clear link between the endocannabinoid system and the pathophysiology of osteoarthritis, which is a degenerative joint disease associated with chronic pain and inflammation (4).

One of the key areas CBD is thought to support osteoarthritis specifically is through the effects on an enzyme known as 5-lipoxygenase — AKA 5-LOX. CBD has been shown to inhibit this enzyme (7), which converts fatty acids into pro-inflammatory compounds. These inflammatory messengers have been shown to be a key component in the underlying inflammation involved with osteoarthritis (8).

By reducing the underlying causes of arthritis pain, CBD is thought to reduce the overall burden of pain from the condition over the long term.

3. CBD and Multiple Sclerosis (MS) Pain

Due to its antioxidant and anti-inflammatory properties, CBD is a potent neuroprotective — which is how experts believe CBD is able to relieve debilitating MS pain, —which affects roughly 50–70% of patients diagnosed with the condition.

A study conducted on animals at Cajan Institute tested the anti-inflammatory effects of CBD on mice the researchers wanted to find out if CBD can provide a reversed inflammatory response on those cells. After ten days, the researchers found a reduction in inflammatory markers with a rodent encephalitis model designed to imitate the impact MS has on the body (5).

More research is needed to see exactly how these effects are translated to humans. Currently, there are 23 clinical trials currently underway, or planned within the next 12 months seeking to explore the effects of CBD on MS.

4. CBD Oil in Sports: Injuries & Muscle Endurance

Cannabidiol can be applied in two different ways when it comes to pain and physical activities. For example, when you administer CBD orally in the form of oil as a post-workout, it helps alleviate the muscle inflammation that troubles athletes once they go beyond the edge again.

If, however, you’re suffering from an injury, it’s best to apply CBD topically. Its anti-inflammatory and neuroprotective properties allow the cannabinoid to relieve pain and improve regeneration capacities.

Does CBD Have Any Side Effects?

The main reason why parents are so enthusiastic about CBD is that this cannabinoid is completely non-intoxicating, doesn’t cause addiction, and has only a few mild side effects when taken at excessive doses.

Research shows that even doses up to one and a half grams have no severe side effects on human health (9).

Despite being a notoriously safe supplement, there are some side effects of using CBD in high doses. Let’s cover the most common side effects people report from using CBD:

  • Anxiety
  • Brain fog
  • Reduced appetite
  • Mood changes
  • Diarrhea or constipation
  • Dizziness or lightheadedness
  • Drowsiness or fatigue
  • Dry mouth
  • Nausea and vomiting

The most common side effect by far, like other forms of cannabis, is dry mouth. This is best managed by taking your CBD oil along with some juice like pineapple or orange juice.

Another common side effect is lowered blood pressure, which may trigger another unwanted reaction — lightheadedness. This side effect is important to consider if you suffer from low blood pressure already or are taking blood pressure-lowering medications.

Always consult your doctor before using CBD or other cannabis extracts if you’re taking prescription medications or have underlying medical conditions.

In Summary: Buying CBD Oil For Pain

As CBD becomes more popular around the world, scientists are publishing new research on cannabinoids on a near-weekly basis. As time goes on, experts are mapping out the complicated mechanisms CBD and other hemp derivatives are using to support both acute and chronic pain of all different origins.

Here are the main takeaways from the current research:

  • CBD inhibits inflammation at several different levels
  • CBD offers antioxidant support
  • CBD may relieve muscle tension and inflammation
  • CBD interacts with the vanilloid receptors in the brain responsible for regulating inflammatory pain transmission

When it comes to pain, CBD appears to target the cause of the problem instead of just masking its symptoms.

Getting relief on so many levels and without any harmful side effects or risk of addiction is the reason why CBD oil has become so popular over the past half a decade.

I hope this guide has managed to clear up any confusion regarding CBD oil and pain, and given you the insight necessary to find the right CBD oil for the job.

Have you tried CBD oil for chronic pain? Did you feel any difference? Let me know in the comments below!

References:

  1. Brand, E. J., & Zhao, Z. (2017). Cannabis in Chinese Medicine: Are Some Traditional Indications Referenced in Ancient Literature Related to Cannabinoids?. Frontiers in pharmacology, 8, 108.
  2. Alger B. E. (2013). Getting high on the endocannabinoid system. Cerebrum: the Dana forum on brain science, 2013, 14.
  3. Aviram, J., Samuelly-Leichtag, G. (2017) Efficacy of Cannabis-Based Medicines for Pain Management: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Pain Physician, 20(6), E755-E796.
  4. Bruni, N., Della Pepa, C., Oliaro-Bosso, S., Pessione, E., Gastaldi, D., & Dosio, F. (2018). Cannabinoid Delivery Systems for Pain and Inflammation Treatment. Molecules (Basel, Switzerland), 23(10), 2478.
  5. Elliott, D. M., Singh, N., Nagarkatti, M., & Nagarkatti, P. S. (2018). Cannabidiol Attenuates Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis Through Induction of Myeloid-Derived Suppressor Cells. Frontiers in immunology, 9, 1782.
  6. Johnson, J. R., Burnell-Nugent, M., Lossignol, D., Ganae-Motan, E. D., Potts, R., & Fallon, M. T. (2010). Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC: CBD extract and THC extract in patients with intractable cancer-related pain. Journal of pain and symptom management, 39(2), 167-179.
  7. Takeda, S., Usami, N., Yamamoto, I., & Watanabe, K. (2009). Cannabidiol-2′, 6′-dimethyl ether, a cannabidiol derivative, is a highly potent and selective 15-lipoxygenase inhibitor. Drug Metabolism and Disposition.
  8. Lascelles, B. D. X., King, S., Roe, S., Marcellin‐Little, D. J., & Jones, S. (2009). Expression and activity of COX‐1 and 2 and 5‐LOX in joint tissues from dogs with naturally occurring coxofemoral joint osteoarthritis. Journal of orthopaedic research, 27(9), 1204-1208.Chicago
Nina Julia

Nina created CFAH.org following the birth of her second child. She was a science and math teacher for 6 years prior to becoming a parent — teaching in schools in White Plains, New York and later in Paterson, New Jersey.

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