Posted on

Cbd oil dosing for spondylosis

Cannabidiol reduces inflammation and pain associated with AS (Ankylosing Spondylitis).

CBD as a treatment for the chronic pain of ankylosing spondylitis (AS) is gaining ground as a pain management alternative. Current treatments, such as the nonsteroidal anti-inflammatory drugs (NSAIDs) naproxen and indomethacin, are the medications doctors most often recommended for ankylosing spondylitis. However, there may be undesirable side-effects: bloating and gas, gastrointestinal bleeding, ulcers, vomiting, diarrhea, or constipation.

Unresolved pain can result in conscious and unconscious reflex responses that are far from optimal. Unrelieved pain also impacts health, social and occupational interactions, mental and emotional states.

What is ankylosing spondylitis?

Ankylosing spondylitis is a type of spinal arthritis and an autoimmune disease. As with rheumatoid arthritis, AS pain is an overactive inflammatory response to the disease itself, which leads to damage to healthy tissue. Over time, AS can cause vertebrae to fuse, leading to the distinctive hunched posture, and loss of spinal flexibility. It can even affect the ribcage, leading to difficulty in breathing deeply.

AS occurs more often in men than women, with symptoms beginning in adulthood (17 – 45). However, onset has been noted in children and the elderly.

Signs and symptoms typically begin in early adulthood. They may include pain and stiffness in the lower back and hips, neck pain, and fatigue. It’s also common for AS to cause eye inflammation or inflammation in other areas of the body. AS also affects areas where tendons and ligaments attach to bones, primarily along the spine, as well as the Achilles heel tendons and the cartilage between the breastbone and ribs.

There is no cure for ankylosing spondylitis. Treatment can help manage symptoms and perhaps slow the progression of AS.

Standard treatment regimen of CBD for AS

Treatment for ankylosing spondylitis involves a multi-pronged approach of medication, exercise, and physical therapy. NSAIDs are usually the first line recourse for the management of pain and inflammation. The potential side effects of NSAIDs have been noted above. Practicing good posture and the application of hot/cold packs are other treatment options.

Pain and fatigue are key symptoms. Given the individualized response to treatment, there are clinical challenges. The progressive nature of AS makes it difficult to rely solely on a single medication over the course of the disease. Opioids, in particular, pose grave risks of addiction and overdose.

CBD for ankylosing spondylitis

As an alternative treatment for the chronic pain of ankylosing spondylitis, CBD is a good choice. Studies reported in the Journal of Experimental Medicine showed that CBD reduced chronic pain and inflammation in some subjects.

CBD is a potent anti-inflammatory that inhibits cell proliferation, which basically means the cell production and division that are responsible for the excessive build-up of bone tissue in the vertebrae.

CBD also suppresses cytokine production, responsible for between cells for immune response. Cytokines stimulate responses towards the inflamed sites.

Cannabidiol also induces T-regulatory cell production to combat the adverse effects of an overactive immune system.

Because AS is an autoimmune disease, it begins at a cellular level, and that is where CBD is at its most helpful. In simple terms, CBD calms the immune response and helps to lessen pain and inflammation.

The human body’s endocannabinoid system (ECS) regulates pain and the body’s immune response, among its other functions. Made up of receptors in the central nervous system (CB1) and the immune system (CB2), the ECS promotes and facilitates the production and delivery of the body’s neurotransmitters. The ECS’ role in healing inflamed tissue correlates clinically with preventing and treating inflammation-induced pain.

The National Institutes of Health sponsored an investigation into CBD’s role in reducing chronic pain and inflammation. The research has shown that CBD’s anti-oxidative and anti-inflammatory properties were instrumental in reducing chronic pain. CBD acts on your body’s CB1 receptors to mute the pain signal to the brain through the cellular mechanisms outlined above.

Frontiers in Pharmacology reviewed studies done between 1975 and 2018 into the effects of CBD on pain. In the studies, researchers investigated pain as a symptom of arthritis. The 2018 review concluded that CBD is an effective treatment for pain, with few side effects.

Cannabidiol agonist activity (initiation of a physiological response, combined with a receptor) at CB2 receptors appears to be responsible for its anti-inflammatory properties and its influence on pain perception. Initial human and animal studies support the premise that CBD reduces chronic pain and inflammation.

CBD has another role in improving pain and inflammation related to AS, and that is in improving sleep quality. Poor sleep may be a result of pain, which in turn impacts pain management. Proper rest improves not only pain management efficacy but also mood that can play a part in improving perceived pain.

See also  Cbd oil dosage for human

Many drugs used to treat chronic pain carry a significant risk, not only of addiction but also of breathing-related sleep disorders. Opioids are the most common culprits, especially when combined with central nervous system depressants. CBD, on the other hand, is non-addictive and has few side effects, but as always, consult the doctor before beginning a CBD regimen.

How to use CBD for AS

CBD comes in many forms, but the most common ways to take it are orally or topically. Capsules or tinctures are the most common oral forms. It may take as long as 2 hours for CBD capsules to begin working, depending on stomach contents and digestive health.

Sublingual sprays or tinctures offer better absorption, going directly into the bloodstream. Users hold the liquid under the tongue for 1 – 2 minutes. The CBD should take effect in about an hour.

Usually, it takes time and experimentation to find an effective dose. Most new users begin with two 5 mg doses, taken morning and evening. Every 7 – 10 days, increase each dose by about half until pain relief is effective.

CBD topicals come as lotions, ointments, creams, and balms and are applied directly to the skin where pain relief is desired. Ointments, salves, and balms tend to require fewer applications than lotions and creams. Some early research has shown that topical applications can have better absorption rates than oral rates. Apply generously and frequently for pain relief.

Whether taken orally or used topically, find a provider that can show a third-party testing analysis. The analysis will show the purity and ingredients. The certificate of analysis should also show how much CBD is delivered per dose. The goal is CBD purity of greater than 98%. The remaining ingredients should be other cannabinoids, terpenes, and flavonoids, as well as the carrying agent.

The science into CBD and its potential for conditions such as ankylosing spondylitis is in the very early stages. Preliminary studies, trials, and user reports show that CBD holds great promise for the relief of chronic pain.

CBD Oil for Ankylosing Spondylitis [How Does It Work?]

Among the top reasons why people use CBD are chronic pain, aching joints, and arthritis. These are all symptoms that affect people with ankylosing spondylitis. So, how can the cannabinoid benefit this debilitating disorder?

Here’s our complete guide to CBD oil for ankylosing spondylitis. We’ll discuss how it works and how to use it for maximum effect. But first, here’s a brief overview of the condition.

What Is Ankylosing Spondylitis?

Ankylosing spondylitis is a condition involving inflammation of the spine. It can also cause inflammation of the joints (arthritis) and the points where ligaments and tendons connect to bone (enthesitis).

Unlike many inflammatory conditions, ankylosing spondylitis tends to affect young people. It usually becomes evident during the teenage years or early adulthood. It is more common in men than in women.

Ankylosing Spondylitis Symptoms

The symptoms of ankylosing spondylitis can range from mild to disabling. Some patients experience back pain that comes and goes and may even improve over time. However, for others, the disease follows a more progressive course.

In severe cases, ankylosing spondylitis can cause permanent spinal damage.

As the body tries to compensate, it generates new bone, causing the vertebrae to fuse. This leads to a loss of flexibility and mobility, known as ankylosis. It can also affect the ribs and cause breathing problems.

Other ankylosing spondylitis symptoms include:

  • Painful, swollen joints
  • Pain in the buttock area
  • Fatigue
  • Eye inflammation (iritis)
  • Increased risk of osteoporosis
  • Increased risk of cardiovascular disease

People with ankylosing spondylitis also frequently suffer from sleep disturbances. This is primarily due to pain and difficulty getting comfortable at night.

What Causes Ankylosing Spondylitis?

Ankylosing spondylitis is associated with changes in a gene known as HLA-B. It is responsible for regulating the production of proteins in the immune system.

The genetic variation HLA-B27 exists in around 90% of ankylosing spondylitis patients. However, not everyone with this variation develops the disease. Some scientists believe that environmental factors can trigger the condition’s onset in susceptible people.

Understand the difference!…

Ankylosing Spondylitis Treatment (Not CBD)

Physical activity tends to relieve ankylosing spondylitis pain. Therefore, physical therapy and exercise are among the most effective treatments. Massage and daily stretching can also help.

Patients who need additional pain-relief may find the following medications beneficial:

  • Traditional painkillers, including opioids
  • Non-steroidal anti-inflammatory drugs
  • Tumor necrosis factor (TNF) inhibitors
  • Disease-modifying drugs
  • Corticosteroid injections
See also  Cbd oil for dogs oahu

The problem with most of these medicines is that they can cause unpleasant side effects, especially with long-term use. Therefore, many patients are wondering whether natural remedies like CBD can help ankylosing spondylitis.

Does CBD Help Ankylosing Spondylitis?

There is currently no research on CBD for ankylosing spondylitis, specifically. However, a study is in the pipeline. It aims to test the efficacy of cannabinoids for ankylosing spondylitis and rheumatoid arthritis.

As the prospective researchers explain, these are two systemic inflammatory conditions. And one of the most significant ways that cannabinoids work is by reducing inflammation. They do this by interacting with the body’s endocannabinoid system (ECS). The ECS has a regulatory function over many of our physiological processes, including the inflammatory response.

Inflammation is the immune system’s way of dealing with injuries or infections, and, in acute situations, it is highly beneficial.

However, sometimes the immune system can become overactive and generate inflammation for no apparent reason. This leads to a variety of painful conditions, including ankylosing spondylitis. It appears that this is where cannabinoids like THC and CBD can help. They dampen immune system activity and reduce inflammation and pain.

THC exerts its effects by binding directly with cannabinoid receptors in the ECS. However, CBD works slightly differently. It seems to enhance the activity of the body’s natural cannabinoid compounds to produce healing without intoxication. CBD also affects several receptors outside the ECS, adding to its overall effectiveness.

So, while CBD will not cure ankylosing spondylitis, it could provide symptomatic relief.

Research on CBD Oil for Inflammation and Pain

Although there are no existing studies on ankylosing spondylitis and CBD, plenty of research has been conducted on inflammation and pain.

One such study appeared in the European Journal of Pain in 2016. Its authors investigated the effects of transdermal CBD on rats with inflammation due to arthritis. They massaged CBD gel into the rats’ skin for four days. At the end of this timeframe, the rats showed reductions in joint swelling and pain.

The study also showed that CBD reduced the activity of pro-inflammatory chemicals, including TNF-alpha. The authors concluded:

“…transdermal administration of CBD has long-lasting therapeutic effects without psychoactive side-effects. Thus, [the] use of topical CBD has potential as [an] effective treatment of arthritic symptomatology.”

A more recent 2019 study for Postgraduate Medicine found that CBD also benefits humans living with chronic pain. It included 97 participants with painful conditions who had been using opioids for at least one year.

After taking full-spectrum CBD hemp extract for eight weeks, 53% of the participants either reduced or stopped their opioid use. Moreover, an impressive 94% of the participants said that their quality of life had improved. One significant aspect of this was better sleep.

How to Use CBD for Ankylosing Spondylitis

There are many different CBD products, and choosing the best one for ankylosing spondylitis can be challenging. The primary consideration is whether to use CBD orally, by inhalation, or as a topical cream. Each option has pros and cons.

Oral Consumption

Oral CBD products include oils, capsules, and edibles. Consumers take them by mouth, and the cannabinoid passes through their digestive system into the bloodstream. The main advantage of this is that CBD can influence the whole body, making it ideal for systemic symptoms.

The downside of oral CBD consumption is that it has a low bioavailability rate. This means that much of the active ingredient is lost in the metabolization process.

According to a WHO report, the body can utilize as little as 6% of oral CBD products. That can lead to significant waste, especially considering the cost of high-quality CBD.

Inhalation

Inhalation offers a higher bioavailability rate. This consumption method includes vaping or smoking high-CBD hemp flower. Inhalation also provides almost instant effects, making it popular among those living with painful conditions.

The obvious disadvantage is that smoking is bad for the lungs. It is also pro-inflammatory and could exacerbate ankylosing spondylitis symptoms. Most experts consider vaping a safer option, but the long-term effects are still unclear.

Topical Application

Finally, topical creams and balms provide targeted relief in a specific area. They allow CBD to absorb through the skin rather than the digestive tract, making them popular among people with aches and pains. These products may also contain other anti-inflammatory ingredients to provide another level of relief.

The main drawback is that CBD topicals are only effective in a specific area. Therefore, they may not be the best for ankylosing spondylitis patients with pain in multiple joints. Of course, it is possible to apply these products to more than one area, but this can become expensive.

See also  Order good cbd oil for anxiety on line

Full-Spectrum vs. CBD Isolate

A further consideration for anyone wishing to try CBD oil for ankylosing spondylitis is whether to choose full-spectrum CBD or an isolate. The former contains a range of cannabinoids and terpenes, while the latter contains almost pure CBD.

Many experts consider full-spectrum CBD products superior.

They believe that the various active compounds in cannabis and hemp work together synergistically. This phenomenon is widely known as the entourage effect.

Furthermore, other cannabinoids such as CBG and CBC have anti-inflammatory and painkilling effects. So do various terpenes. Therefore, full-spectrum CBD allows consumers to benefit from therapeutic properties beyond CBD alone.

However, full-spectrum products do contain trace levels of THC. Although it is not enough to cause intoxication, it may cause some people concern. In this case, CBD isolate may be the solution.

Another compromise is broad-spectrum CBD, which is essentially full-spectrum minus the THC. These products are more difficult to come by, but they are steadily becoming available from an increasing number of manufacturers.

When buying any kind of CBD for ankylosing spondylitis, choose a company that provides third-party lab reports. They tell potential customers precisely how much of each cannabinoid their products contain and indicate a reliable brand.

CBD Oil for Ankylosing Spondylitis: Final Thoughts

There is no research currently available on CBD oil for ankylosing spondylitis. However, there is evidence of its anti-inflammatory and pain-relieving properties. This could be enough to inspire those looking for natural alternatives to prescription painkillers to try it.

While CBD is safe for most people, we advise anyone trying it for the first time to consult a physician first. They will ensure that CBD is a suitable treatment, whether for ankylosing spondylitis or any other condition.

Understanding CBD (Cannabidiol) for Back Pain

Cannabidiol, commonly referred to as CBD, is a new and relatively understudied treatment for pain, including back pain. Studies suggest it may help relieve inflammation, which is often a factor in chronic back pain. 1

CBD is available in many forms; topical creams and gels have shown promising results for inflammation and neuropathy, which may make them a good option for back and neck pain. 2

CBD requires more research in order to prove and explain its effectiveness as well as to better understand potential side effects (especially long-term) and potential drug interactions.

What Is CBD?

CBD oil is derived from a plant called cannabis sativa. The plant has over 100 chemical compounds, called cannabinoids, that have a range of effects, including anti-inflammatory and analgesic (pain relieving) qualities.

The cannabis sativa plant has two main varieties that are grown for specific purposes:

  • THC content. THC is the compound associated with the “high” feeling of marijuana use.
  • Industrial (non-drug) uses. This form of the plant contains trace amounts of THC (less than .03%) and can be used to make paper, clothing, and some building material. This variation of the cannabis plant is called hemp.

While CBD is present in both varieties, many of the CBD products available to consumers are from the hemp plant. CBD does not come with the high or psychogenic effects of marijuana.

Ways CBD Treats Back Pain

Research indicates that CBD may reduce back pain by:

  • Reducing inflammation 3
  • Combating anxiety, often associated with long-lasting or chronic back pain 4
  • Helping with sleep and improving overall state of relaxation 5

Some studies suggest that CBD can have an effect on how an individual perceives pain, but more robust research is needed. CBD is generally considered a full-body treatment, which means that it does not target back pain specifically—except in the case of topical products—but contributes to an overall feeling of relaxation and pain relief.

Advocates of CBD believe it can be used to treat a range of conditions in addition to back pain, such as anxiety-related disorders. 5

Potential Risks and Side Effects of CBD

Cannabidiol, even in high amounts, is generally safe. Side effects from CBD may include:

  • Drowsiness
  • Dizziness
  • Dry mouth
  • Low blood pressure

More severe side effects, while rare, include:

  • Mental confusion
  • Nausea
  • Vomiting
  • Diarrhea

As with other natural products, there is potential for adverse reactions when taken with other medications, especially those that come with grapefruit warnings, such as certain blood thinners. These warnings indicate that certain medications should not be taken with products containing grapefruit.

CBD use prior to surgery

Before having surgery, all cannabis use, including CBD and marijuana, should be disclosed to the surgeon or anesthesiologist. A recent study suggests that cannabis use may have an effect on medications used to sedate patients. 6