How CBD can help for Autonomic Dysfunction
The autonomic nervous system controls the functions responsible for well-being and the maintenance of balance. Autonomous dysfunction occurs when the system is not properly regulated.
Table of Contents
Autonomic dysfunction is commonly called autonomic neuropathy. And describes many conditions caused by damage to the autonomic nervous system (ANS). The ANS is the division of the peripheral nervous system that unconsciously controls body function:
- Heart rate.
- Control of blood pressure.
- Regulation of temperature and digestion.
Parkinson’s disease can cause orthostatic hypotension and other symptoms of ANS damage. This often causes significant disability in individuals with this disease. Several common conditions such as diabetes and alcohol abuse can include autonomic neuropathy.
Autonomic Dysfunction Types and Side Effects
CBD oil for autonomic disfunction
Neurocardiogenic syncope (NCS) is the most common autonomic dysfunction. It affects tens of millions of people worldwide. The main symptom is fainting, also called syncope. This can occur on occasion only, or it may be frequent enough to disrupt a person’s daily life.
Multiple system atrophy (MSA) is a fatal form of autonomic dysfunction. It has similarities to Parkinson’s disease, nonetheless, with a life expectancy of only 5 to 10 years from its diagnosis.
Orthostatic hypotension is a type of orthostatic intolerance. Which occurs when blood pressure drops significantly when standing up, including fainting.
Postural orthostatic tachycardia syndrome (POTS) is an abnormal increase in heart rate that occurs after sitting or standing. Is diagnosed only when orthostatic hypotension has been ruled out. And besides, there is no acute dehydration or blood loss.
Holmes-Adie syndrome (HAS) affects the nerves that control the muscles of the eye, causing vision problems. One pupil will likely be larger than the other, and it will constrict slowly in bright light. It mostly affects the nerves controlling the muscles of the eye, causing vision problems.
Hereditary Sensory and Autonomic Neuropathy (HSAN) is a genetic disorder that affects the development and survival of certain nerve cells. Problems related to this disorder first appear during infancy. Early signs and symptoms include:
- Poor muscle tone.
- Feeding difficulties.
- Poor growth.
- Lack of tears.
- Frequent lung infections.
- Difficulty maintaining body temperature.
Older infants and young children may hold their breath for prolonged periods of time. Which may cause a bluish appearance of the skin or lips (cyanosis) or fainting.
Traditional Treatment for Autonomic Dysfunction
There is no cure for most types of autonomic dysfunction. Nonetheless, symptomatic treatment is available for many symptoms associated with this disease, and some disease processes can be treated directly.
The prognosis for people with autonomic dysfunction depends on the particular diagnostic category. People with chronic, progressive, and generalized autonomic neuropathy generally have a poor long-term prognosis. Death can occur from pneumonia or acute breathing failure.
The illness is difficult to diagnose and an incorrect diagnosis is common. Symptoms can be mistaken for those of another condition that is already present. Diagnosis is made by functional testing of the ANS, focusing on the affected organ system. A successful diagnosis often results from collaboration between several specialists.
In any case, the neurologist will review the results of previously performed tests. And it will create a report that includes a detailed diagnosis and treatment plan.
On the one hand, the treatment can help people control their side effects and experience a better quality of life. Those treatments plans may include medications to:
- Help stabilize blood pressure.
- Control symptoms such as intolerance to high temperatures.
- Control digestion problems and bladder function.
On the other hand, it also helps to change life habits such as:
- Drink plenty of fluids (better fortified with electrolytes.)
- Elevating the head of your bed.
- Adding salt to your diet.
- Changing positions slowly.
- Exercise regularly.
- Wear clothes to improve vasomotor problems (compression stockings, compression tights and cooling vests).
Another alternative may be Cognitive Behavioral Therapy (CBT), which can be combined with mindfulness.
CBT is based on the idea that thoughts and responses create negative moods. By identifying and adjusting inaccurate or distorted thoughts, moods can be improved. CBT is very helpful when it comes to chronic or recurring thoughts.
Patients with the disease can become frustrated in reaching a diagnosis and dealing with the healthcare system. So thought patterns emerge that can be detrimental to physical and psychological health.
What is CBD and How Does it Work for Autonomic Dysfunction?
CBD is a component present on the cannabis plant and on hemp plants. This component is the main component to use on medicinal products.
We at Canalanza obtain the purest CBD at 99.3% being one of the top ones obtaining this purity. Finca Canalanza is located in the Biosphere Nature Reserve in the Volcanic Canarian island of Lanzarote
CBD is only one component of the many components that helps the endocannabinoid system.
CBD is a non addictive component. It is found on the cannabis plant and hemp plants. Always is necessary a long term contract by FDA approved or an AMPS approval to produce or to sell CBD products.
In summary, CBD is a non addictive natural compound with great potential in natural and therapeutic medicine. Today, research on the multiple benefits of CBD on improving the ailments of various diseases is encouraging.
How can help CBD with Autonomic Dysfunction
CBD is the major no psychotropic effect component extracted from the Cannabis plant. CBD interacts with the human endocannabinoid system and has shown positive results in regulating and stabilizing it.
Cannabinoids in cannabis have been shown to stimulate neuroregeneration and limit neuronal damage. They also play a role in regulating the immune system. These effects regulate inflammatory reactions through components of adaptive and innate immune responses.
Cannabinoids have been shown to be potentially effective for autonomic neuropathy through their interaction with the endocannabinoid system. Which is a complex system, responsible for regulating various bodily processes to maintain health and prevent disease.
The modulation of the endocannabinoid system has shown to be medically beneficial by slowing down the progression of neuronal disorders. One study provided evidence that activation of CB2 receptor attenuates autonomic function after a spinal cord injury.
Some symptoms of autonomic dysfunction that CBD can help with include:
- Nausea and vomiting: cannabinoids work as an antiemetic.
- Sexual functioning: There is a positive association between cannabis and impotence and it helps with erectile function.
- Lack of appetite: Medical cannabis stimulates your metabolism, which helps increase your hunger. It can also help you gain weight.
- Diarrhea: works as a treatment for stomach problems and intestinal disorders.
- Anxiety: CBD (such as CBD oil) has similar propqerties to manufactured medicines.
- Depression: Provides energy to the user and improves their mood to help them with depressive emotions.
- Inflammation: It can effectively reduce chronic inflammation and pain related to inflammation.
CBD and Autonomic Disfunction
Studies indicate that CBD seems to be beneficial in preventing and treating autonomic dysfunction. In addition, it has shown to have antioxidant and neuroprotective properties. That it supports the health of the nervous system and could limit or prevent damage to the nerves. Cannabinoids found in cannabis, including CBD, have shown to be effective in limiting neuronal damage and promoting neurological regeneration.
Another study shows that cannabinoids play a role in regulating blood pressure. Cannabinoids that activate CB1 receptors have shown that blood vessels dilate, improving blood flow and reducing blood pressure. However, these findings may be of concern for those with low blood pressure and who are subject to fainting.
The vasodilator effect has been shown to help normalize blood pressure in people with hypertension. So the reduction in blood pressure caused by cannabinoids can increase the risk of fainting in a person with ANS.
How to take CBD OIL for Autonomic Dysfunction?
Now we know how the Natural CBD Oil elaborated by Laboratorios Canalanza can help you with most of the common symptoms.
Our suggestion is to start using our CBD oil Canalanza with 3-5 drops. Starting in the morning, before breakfast and under the tongue.
Leave the oil to dissolve with saliva for at least one minute.
Put 2-3 drops before having lunch and another 3-5 at night half an hour before going to sleep.
For better results increase with 1-2 drops in the morning dosage and 2-3 at night.
Our CBD oil has a natural flavor due to the Extra Virgin Olive Oil used as the base.
How to Buy CBD Oil for Autonomic Dysfunction online?
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The Effects of Cannabidiol (CBD) on Electrical and Autonomic Cardiac Function in Children With Severe Epilepsy (CBD1)
The investigators propose to study the effects of cannabidiol (CBD) on cardiac electrical function and the autonomic nervous system in children with Dravet syndrome (DS) and Lennox-Gastaut syndrome (LGS), when the CBD is administered as an artisanal oil obtained through state dispensaries or other sources. The intent is to begin to assess potential risks and benefits of this therapy in a vulnerable patient population by characterizing the effects of CBD on EKG findings, heart rate variability and the occurrence of seizures.
|Condition or disease||Intervention/treatment||Phase|
|Lennox-Gastaut Syndrome Dravet Syndrome||Procedure: 12-Lead ECG Drug: Cannabidiol||Phase 1 Phase 2|
Specific Aims/Study Objectives
This is a pilot study to explore the effects of cannabidiol (CBD) on autonomic cardiac function in children with Dravet syndrome (DS) or Lennox-Gastaut syndrome (LGS) when the CBD is administered as an artisanal oil. This will be achieved by addressing the following specific aims.
Aim #1: To determine the effects of CBD on cardiac function in 30 children with DS and LGS. This is the primary aim of the study: The effects of CBD on the cardiac function of 30 children with DS or LGS will be assessed using a 15-lead electrocardiogram (EKG) and a 24-hour Holter monitor. Investigators hypothesize that there will be no alterations in ventricular repolarization and heart rate variability on the EKG and Holter monitoring, respectively, after taking CBD for 4-8 weeks, compared to when participants were not taking CBD.
Note: The following aims are secondary to the primary outcome and goal of assessing the effects of CBD on cardiac function.
Aim #2: To assess signs and symptoms of dysautonomia in the presence and absence of CBD. Signs and symptoms of dysautonomia include parental perception of body temperature, skin color in hands and feet, sweating, pupil size, flushing, feeding issues, heart rate, strong emotions, constipation, urination or bowel movement issues, and irritability. These signs and symptoms will be collected using a previously-established dysautonomia survey. Investigators hypothesize there will be no change in qualitative assessments of signs and symptoms of dysautonomia after taking CBD for 4-8 weeks, compared to when participants were not taking CBD.
Aim #3: To determine the effects of CBD on the occurrence of seizures. The number of seizures in children who obtain CBD will be assessed using a 7-day seizure diary (Seizure tracker). Caregivers will record the number of seizures for a 7-day period prior to CBD administration, and repeat the seizure tracking after having received CBD for 4-8 weeks. Change in seizure numbers will be compared pre- and post-CBD administration. Investigators hypothesize that study participants will have lower seizure counts after being on CBD compared to when weren’t taking CBD.
Study Design and Methodology
Study Design: Thirty patients with DS or LGS who are going to register to take medical cannabis (cannabidiol, or CBD) in the state of Minnesota will be offered the opportunity to participate in this study. If consent is obtained, the patient or guardian will be asked to complete a questionnaire developed for this study that documents observable signs and symptoms of dysautonomia, and to complete a seizure diary for 7 days prior to initially receiving the CBD. Each participant will also have a 15-lead electrocardiogram (EKG) and wear a 24-hour Holter monitor, both non-invasive measures of cardiac function, prior to being administered the CBD. The EKG and 24-hour Holter monitor will be interpreted by a cardiac electrophysiologist and will be reviewed for heart rate variability parameters. The dysautonomia questionnaire, seizure diary and cardiac measurements will be repeated 4-8 weeks after the subject has been on a stable regimen of CBD. This time-frame is based on availability of subjects schedules and clinic visits, and it is also greater than 5 half-lives previously reported for CBD (apparent half-life, 21 hours, (15)). Steady-state levels are achieved after 5 half-lives of drug dosing, thus we expect to be at steady-state concentrations.
Subjects who are already on a stable regimen of CBD, yet plan to stop taking CBD at some point for some reason, are also eligible to participate. The parent or guardian will complete the dysautonomia questionnaire and seizure diary (and research staff will be available to help with questions), and the patient will have the 15-lead EKG and 24-hour Holter monitor while still on the CBD. The subjects will then come back 4-8 weeks after their last dose of CBD to have these assessments repeated while off of the CBD. This time frame is based on availability of subjects schedules and clinic visits as well as being substantially greater than 5 half-lives of CBD, the standard wash-out period for pharmacological studies.
The influence of marijuana on physiologic processes and exercise
Introduction [ edit | edit source ]
Cannabis use is widespread, totaling more than 400 possible compounds with the most prevalent compound being Tetrahydrocannabinol (THC). THC has a psychotropic effect on the central nervous system by acting on CB1 and an analgesic by working on CB2 receptors. CB1/CB2 receptors are activated by the attachment of the ligand, Anandamide  . Marijuana has been shown to elevate resting heart rate and systolic/diastolic pressure after consumption  . Marijuana has also been seen to produce bronchodilation in patients with bronchoconstriction secondary to asthma  . Many athletes consume marijuana for their euphoric effects by reducing stress and anxiety. Reducing stress before competition allows for adequate sleep, which allows for optimal performance  .
Tetrahydrocannabinol is the primary constituent of marijuana that binds to G-Protein-Coupled CB1 receptors which are found throughout the brain in the frontal and medial temporal lobe  . Marijuana is one of the most frequently used drugs among young adults. Marijuana induces tachycardia which can decrease the maximal work capacity after smoking this drug  . Marijuana creates an increase in carboxyhemoglobin concentration of blood due to large amount of carbon monoxide created from the smoking of this drug  . Some other factors that could affect the maximal work capacity after smoking marijuana are bronchodilation, a decrease in the perception of dyspnoea and an increase in blood flow to exercising muscles  . Despite the increase in maximal work capacity, the utilization of marijuana with exercise has a negative correlation that greatly affects overall health.
Cardiovascular Effects [ edit | edit source ]
Marijuana use has both acute and prolonged effects on the cardiovascular system, drastically altering the normal functioning of the entire system. The initial intake of THC increases heart rate, causes hypertension during sitting, and hypotension whilst standing  . A person may develop a tolerance to these symptoms quickly  . Determining how long the patient has been using marijuana and the frequency that he or she uses it can help determine if heart rate and blood pressure is within normal limits. In addition, there are potential risks of orthostatic hypotension and dizziness that can come with frequent marijuana use  . A person’s blood volume goes up and the circulatory system response decreases. Concerns over the decrease in blood pressure and quick loss of mental orientation should be brought to the attention of the physical therapist during evaluation and treatment of patients using recreational marijuana. The influence of marijuana would affect how a patient responds to standard examinations and exercise during treatment. Patients who have cardiovascular disease are much more likely to have health problems because their heart has to work harder, their catecholamine levels go up, and postural hypotension happens.  Prolonged effects of frequent marijuana use could have more adverse effects as tolerance level is increased including alterations to the plasma volume  .
To provide evidence to this data, Lindsay, Foale, Warren, & Henry (2005) studied two different cases. This first case involved a 48-year-old man who had a terrible history of heart problems: coronary artery bypass 10 years prior, recurrent angina for 18 months, unstable grafts, and a sub-total occlusion of a previous stent to the left main stem. The patient for Case 1 was admitted for urgent coronary angiography. Approximately 24 hours after admission, the patient suffered cardiac arrest while smoking, what was thought to be, a cigarette. Once the medical staff got to his side to resuscitate him, they noticed that the room smelled like cannabis and the ‘tobacco cigarette’ was actually a ‘cannabis cigarette.’ The Case 1 patient survived the cardiac arrest and stayed in the intensive care unit for ten days. The patient also admitted to being a chronic cannabis user for many years  .
Another case reported by Lindsay, Foale, Warren, & Henry (2005) involved a 22-year-old man who was admitted to the hospital with two episodes of chest pain and shortness of breath. On both occasions, he admitted having smoking cannabis at the beginning of each attack. The patient for Case 2 had no family history or personal history of coronary artery disease or cardiovascular disease. The Case 2 patient admitted to smoking cannabis regularly since his mid-teens and had increased his frequency and potency of his cannabis habit within the two weeks prior to the hospital admission  .
Both cases provide evidence that prolonged cannabis use is highly detrimental to the cardiovascular system, whether the patient has a history of cardiovascular problems or not. The evidence also defies the myth that heart problems only happen to older individuals.
Marijuana has been shown to increase heart rate and blood pressure while decreasing overall cardiac output  . This is important for clinicians to consider when treating patients who use marijuana, as it is an ergolytic drug. When used in combination with exercise it will negatively affect the patient’s exercise performance and overall health.
Neuromuscular Effects [ edit | edit source ]
Marijuana could positively affect the ability of people with underlying neurological conditions to exercise. Reduction of symptoms could allow these people to exercise more effectively and frequently. A systematic review of patients with neurological disorders including multiple sclerosis, movement disorders, and epilepsy showed that some of the debilitating effects of these diseases were reduced after the intake of cannabis extracts  . Most notably, it was found that oral cannabis extract was effective in reducing patient-reported scores of spasticity, allowing them to move freely and have better control of movements. It was also found to be effective in reduction of central pain in patients with multiple sclerosis  . Another condition that symptoms could be reduced enough by cannabinoids to promote ease of movement for exercise is rheumatoid arthritis. Rheumatoid arthritis causes inflammation in a joint along with cartilage damage. The long-term effects of inflammation can cause changes in sympathetic activity that continue to cause inflammation. Activation of cannabinoid receptor type 1 (CB1) by cannabinoids can lower sympathetic activity in the brain and can affect the amount of neurotransmitters released, providing anti-inflammatory effects in other regions of the body  . Marijuana use has a direct effect on the central nervous system because it contains the receptor sites for THC  . Although marijuana does possess some ergogenic effects in certain situations, it impacts the body oppositely during exercise. The drug has a sedative effect during exercise, resulting in decreased exercise and psychomotor performance like slower reaction time  .
Pulmonary Effects [ edit | edit source ]
Marijuana also has its effects on the pulmonary system. Specifically, research has shown a high association between marijuana use and certain respiratory issues, such as coughing and wheezing  . In addition, the drug causes inflammation, bronchodilation, and diffusion impairment  . These conditions would have a negative impact on a person’s ability to adhere to a rigorous exercise routine. Diffusion impairment would especially affect the amount of oxygen successfully entering the alveoli of the lungs, decreasing the amount of oxygen available for use during strenuous activity. Therefore, physical therapists would take extra precautions and plan exercise treatment accordingly as to prevent overexertion and fatigue.
A 2002 longitudinal study measured the relationship between long-term marijuana use and lung function. Lung function was measured using spirometry and the ratio of forced expiratory volume in one second/vital capacity (FEV1/VC). The study was conducted over an eight-year period and measured over 900 young adults. The results showed a dose-dependent relationship between marijuana use and decreased lung function