CBD for Anemia – May 2022
Anemia occurs when the body lacks enough hemoglobin on red blood cells to carry adequate oxygen to the tissues. Having anemia can make one feel weak and tired.
There are many forms of anemia, and each has a different cause. The condition can be temporary or long term, and it can range from mild to severe.
Anemia can also manifest as a warning sign of a severe illness. When left untreated, anemia can cause severe fatigue, pregnancy complications, heart problems, or death.
Treatments for anemia can range from taking supplements, such as iron, folate, vitamin B12, and vitamin C, to undergoing medical procedures.
Individuals may be able to prevent some types of anemia by eating a healthy diet consistently high in iron, vitamin B-12, and folate (1 ) .
CBD for Anemia: What The Research Says
CBD has been shown to possess therapeutic benefits that might help with symptoms or conditions linked to some types of anemia.
Although further longitudinal research is needed to validate the results of those studies, the potential benefits of CBD as an alternative for managing symptoms cannot be overlooked.
CBD Oil and Sickle Cell Anemia
Sickle cell anemia is a disorder that affects hemoglobin, the molecule in red blood cells that delivers oxygen to cells throughout the body (2 ) .
People with this disorder have atypical hemoglobin molecules called hemoglobin S, which can distort red blood cells into a sickle, or crescent, shape.
Sickle cell anemia can cause the pain linked to an accumulation of misshapen red blood cells in the microscopic capillaries. Also, pain can occur from poor oxygenation of the tissues.
In some cases, individuals with sickle cell anemia are prompted to take potent opioid painkillers to manage the pain.
Unfortunately, opioid therapy, often used for this condition, can lead to dependence or addiction, as indicated in a study published in the Journal of the Royal Society of Medicine (3 ) .
A questionnaire study published in the British Journal of Haematology examined cannabis use in sickle cell disease (4 ) .
52% of those who used marijuana to treat symptoms of the disorder used it to reduce the pain associated with the condition. Meanwhile, 77% said they used it for relaxation or sedation purposes.
A study used an animal model to look at how cannabinoids can be effective at treating the pain from sickle cell anemia (5 ) .
In this study, cannabinoids were shown to reduce neuropathic or nerve-related inflammation involved with sickle cell disease in mice.
Although the studies did not focus on CBD use, the results can be used to develop oral cannabinoids in treating acute sickle cell pain.
CBD Oil and Iron Deficiency Anemia
CBD itself has little effect on iron deficiency anemia. However, hemp seed oil that is often used as a carrier oil in these products is a natural source of vitamin E and minerals, such as phosphorus, potassium, sodium, magnesium, sulfur, calcium, iron, and zinc (6 ) .
Typically, the doses of hemp seed oil used for CBD oil are only a few milliliters per day. For instance, in 100 mL of hemp seed oil, there may be about 8 mg of iron.
The National Institute Of Health says the daily requirements for iron in adults between 19 and 50 years old is 8 mg/day for men, and 18 mg/day in women (7 ) .
The American Society of Hematology recommends taking 150-200 mg of iron each day, or 2 to 5 mg of iron for every kilogram of body weight per day (8 ) .
That much iron is the equivalent of about 1.9 L of hemp seed oil per day, which is an outrageous and unreasonable amount for an individual to take in a day.
Thus, given the modest amounts of iron that can be obtained from hemp seed oil, it is best to stick to iron supplements and other highly-concentrated sources of iron, such as dark leafy vegetables, tofu, and red meat.
CBD for Anemia Symptoms
Iron deficiency anemia can be very mild that, oftentimes, it goes unnoticed. However, as the body becomes deficient in iron and anemia worsens, the signs and symptoms intensify.
- Fast heartbeat, shortness of breath, or chest pain , dizziness or lightheadedness
- Inflammation or soreness of the tongue
- Unusual cravings for non-nutritive substances
- Poor appetite
Meanwhile, studies have shown that CBD can help with these symptoms.
According to a study published in the British Journal of Pharmacology , drastic cannabidiol or CBD administration suppressed irregular heartbeat caused by ischemia-induced heart arrhythmias (inadequate blood supply in the heart) (10 ) . Thus, CBD provides the heart with protection.
A 2014 review from the European Journal of Pharmacology established the potential of cannabis to limit or prevent nausea and vomiting from a wide range of causes (11 ) .
CBD’s potent anti-inflammatory properties were also demonstrated in a 2018 study published in the Journal of Pharmacology and Experimental Therapeutics (12 ) .
In the said study, CBD has been shown to work directly with the cannabinoid receptors of the body to help suppress inflammation.
In an animal study published in the PLOS One Journal, it was shown that CBD inhibits a receptor in the brain so that ghrelin, which stimulates the appetite, is unable to act (13 ) .
Meanwhile, a study on the relationship between cannabinoids and food intake suggested that endocannabinoids could impact energy balance and food intake within the brain (14 ) .
To date, there has been no study that says CBD can directly help improve anemic conditions.
Most of CBD’s benefits for anemia is only for the alleviation of the symptoms linked to anemia, rather than the condition itself.
CBD is non-addictive, says Nora Volkow, director of the National Institute on Drug Abuse (NIDA) in a 2015 article (15 ) . This characteristic makes CBD safe for daily intakes, like a supplement.
Does CBD help with autoimmune disease in dogs?
When you learn that your pet has an autoimmune disease, the diagnosis seems vast and confusing. Autoimmune disease is a term for a broad range of illnesses, but they all have one thing in common: the immune system of the body is attacking itself. When the body has an autoimmune disease, the immune system thinks that healthy tissue is attacking or made of invaders, which can cause organ and tissue damage throughout the body. Although autoimmune diseases can be life-threatening, there are natural ways to keep these conditions under control.
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What causes autoimmune disease?
Autoimmune disease is a term for a wide range of illnesses including lupus, Bullous Pemphigoid, Pemphigus complex, and several others. These diseases can be caused by a wide range of things, including genetics, exposure to certain types of UV light, or even ticks . Autoimmune diseases can even be caused by some medications , like sulfa drugs, that are used to treat infections like urinary tract infections, respiratory and bowel infections. Some veterinarians also theorize that autoimmune disease can be caused by over-vaccination.
What are symptoms of autoimmune disease?
Symptoms of autoimmune disease can show at any time, but typically start around age six or higher. Depending on the type of autoimmune disease, symptoms may be local to the area affected or may be evident in the whole body. The symptoms also vary depending on the disease, however there are a few common signs to look for that your dog may need to be tested for an autoimmune disease.
Common symptoms of autoimmune disease include:
- Increased thirst or urination
- Ulcers on face or feet
- Thyroid issues
- Swollen lymph nodes
- Weight loss or anorexia
- Excessive bleeding
- Discoloration of the nose, skin, or eyes
Because the body is attacking itself, an autoimmune disease can cause multiple issues. For example, it can cause rheumatoid arthritis and inflammation of the joints. Lupus can cause issues in the skin , brain, and digestive system. The symptoms will vary, but they are all worsened by inflammation. Your holistic veterinarian may need to run a variety of tests including blood tests and biopsies to determine which autoimmune disease your pet has, and to determine the cause.
How do you manage autoimmune diseases naturally?
Conventional treatments for autoimmune disease include steroids and other medications which suppress the immune system. However, 80 percent of the immune system is housed in the gut, which means that the gut health is the MOST important when it comes to getting immune system health in check. That means you have to cut the kibble. The best kibble is still not as good for your pet as raw or freeze-dried food. If you are interested in preparing your pet’s food at home, check out the Yin & Yang cookbook .
Once you have switched your pet to a raw or freeze-dried diet, you will notice their inflammation decreasing, which helps with symptoms of autoimmune disease. You can also incorporate digestive enzymes, prebiotics , and minerals to get gut health in check. In addition, CBD can help with the symptoms of autoimmune disease.
Although some types of autoimmune disease are not reversible, you can manage symptoms, further damage, and pain by managing inflammation.
If you have ever known anyone with an autoimmune condition, you may understand how difficult it is to manage. And, the same goes for our pets. Autoimmune diseases are difficult to manage, but fortunately, we have found something to help. CBD can help with various autoimmune conditions in dogs including canine lupus, irritable bowel syndrome, and immune-related arthritis.
One of the main ways that full spectrum hemp extract (CBD) helps with autoimmune disease is by managing inflammation that causes permanent damage.
Compounds found in cannabis that reduce inflammation are abundant and diverse. The most abundant phytocannabinoids in cannabis, THC and CBD, both have strong anti-inflammatory properties. Cannabinoids act as anti-inflammatory agents by inducing apoptosis (AKA cell death), inhibiting cell growth, suppressing cytokine production (the cells responsible for communication with non-immune and immune cells), and inducing T regulatory cells. Cannabinoids have also been demonstrated to promote the production of anti-inflammatory cells (interleukins such as IL-10) while inhibiting the production of pro-inflammatory compounds (Klein et al. 2000).
A Baylor College of Medicine study, using In vitro and in mouse models, found that CBD significantly attenuated the production of proinflammatory cytokines IL-6 and TNF-α while elevating levels of anti-inflammatory IL-10. In the veterinary study, CBD significantly decreased pain and increased mobility in a dose-dependent fashion among animals with an affirmative diagnosis of OA.
Another study published in 2006 in Current Neuropharmacology also states that cannabinoid receptors have shown therapeutic value against inflammatory and neuropathic pains and also concluded that CBD has therapeutic benefits for both people and pets suffering from chronic pain and acute chronic pain episodes.
Immune Boosting Properties
CBD also has immune-boosting properties because it acts as a regulator to bring the body back to homeostasis. In fact, CB2 receptors regulate many complex pathways of the immune system, and preclinical studies show that triggering CB2 receptors can suppress the immune response, which can be beneficial for those suffering from autoimmune disease, according to this study .
The same study also states there has been some investigating on the role of cannabinoids in autoimmune disease models. CBD has been found to regulate the immune system rather than hold it down. CBD does this by slowing down T-cell production and suppressing the memory of the immune system lowering the risk of future autoimmune attacks. In addition to decreasing the likelihood of future AI attacks, CBD increases the expression of genes that handle oxidative stress therefore reducing cell damage.
How much CBD oil should I give my pet for autoimmune diseases?
For autoimmune diseases, we recommend our HEAL 1100 mg full spectrum hemp extract (CBD) tincture . Based on research and my experience, I recommend starting with 35-50 mg (1-2 ml) of HEAL daily and increase if needed. Because every dog reacts differently, you may find that your dog responds better to a higher or lower dosage. You should note that dogs cannot overdose on CBD.
During the first few weeks, we recommend a trial and error method as you monitor your animal’s response and determine optimal dose. The old saying “start low and go slow” is extremely applicable when considering full-spectrum hemp extract for your animal.
Split the total daily dose into 2 or more smaller portions (micro-doses) to maintain consistent blood concentration levels.
According to preliminary research, blood concentration after oral administration typically reaches peak levels after 2 hours and is mostly eliminated from the body within 6-8 hours.
If your pet is suffering from skin damage, lesions, sores, or tumors due to autoimmune disease, apply REMEDY full spectrum hemp CBD salve one to two times daily.
Remember, if your pet is taking medications that suppress the immune system, they may not see the full results or benefits. Discuss weaning from any steroids or medication with your holistic veterinarian.
To learn more about how full spectrum hemp extract (CBD) can help with your dog’s ailments, visit cbd dog health .