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Medications and Supplements of Concern on Benzodiazepines, During Cessation and After Withdrawal

There aren’t any alternatives to benzodiazepines with the same level of efficacy and safety profile in overdose, nor is there a substitute medication to prevent withdrawal from occurring. Barbiturates, like phenobarbital, can be more dangerous than benzodiazepines in overdose, are the most similar drug. This is because both benzodiazepines and barbiturates work on the GABAA receptor in similar ways, and benzodiazepines were created in part to replace the barbiturates, as barbiturate accidental overdoses were often fatal. Patients experiencing benzodiazepine harm usually have sensitized nervous systems and may report adverse reactions to various products they used safely in the past before, like soaps, foods, etc. The same is true for medications.

It should also be noted that antidepressants and some other psychoactive drugs such as antipsychotics can also cause prescribed physical dependence, may also require a lengthy taper, and thus can create their own withdrawal syndromes upon discontinuation . Studies as recently as 2012 have determined that symptoms upon cessation of SSRIs and benzodiazepines are very similar , indicating that cessation of both of these types of drugs can provoke a potentially severe withdrawal syndrome . Some people can even develop psychotic symptoms after stopping an antipsychotic medication even if they’ve never had psychotic symptoms before .

The addition of beta-blockers, antidepressants and antipsychotics should be avoided where possible.

Tools such as pharmacogenomic testing may be of some use in determining which medications may or may not be tolerated, however many benzodiazepine-injured patients report having reactions and sensitivities to medications they had no issues with prior to their benzodiazepine harm.

While benzodiazepine withdrawal syndrome might worsen symptoms in someone who had a pre-existing history of anxiety/depression or other psychiatric symptoms, these worsened symptoms are not likely to be permanent. It is important to note that benzodiazepine withdrawal syndrome causes psychiatric symptoms in patients who took benzodiazepines for physical (non-psychiatric) conditions as well—such as tinnitus, muscle spasms, or vertigo, to name a few. Any other drug which decreases the seizure threshold or interacts with GABA neuroreceptors (is GABAergic), and possibly many others, should be approached with caution in someone suffering benzodiazepine withdrawal or with a history of benzodiazepine physical dependence.

Supplements

Beyond prescription pharmaceuticals, there is no evidence that supplements and herbs solve Benzodiazepine Withdrawal Syndrome and Protracted Withdrawal Syndrome issues. There is evidence and anecdotes that certain medications and supplements that are GABAergic have been associated with harm in those experiencing benzodiazepine issues. Dr. C. Heather Ashton, author of the Ashton M anual , has said:

I have always been against supplements which are often just a money-making scam, and most have never been properly tested. Many people take so-called GABA supplements in benzodiazepine withdrawal. This is futile as there is no shortage of GABA in benzo withdrawal: the problem is the down-regulated receptors. I have always advised people withdrawing from benzos not to waste their money on supplements.

GABA Receptor Downregulation

GABAergic means “pertaining to or affecting the neurotransmitter GABA “. A substance is GABAergic if it produces its effects via interactions with the GABA system, such as by stimulating or blocking neurotransmission. A GABAergic or GABAergic agent is any chemical that modifies the effects of GABA in the body or brain. Some different classes of GABAergic drugs include the following: GABA receptor agonists , GABA receptor antagonists , and GABA reuptake inhibitors . Some examples include gabapentinoids and GABA analogues .

Neuroadaptation occurs with patients on daily prescribed benzodiazepines. This means that their bodies adapt through repeated exposure to a drug, producing long-term changes in the nervous system. Neuroadaptation to the benzodiazepine’s constant presence is the reason for the development of tolerance and a sensitization of the nervous system.

The continual presence of prescribed benzodiazepine may cause down-regulation of the GABA receptors, meaning that the receptors become fewer. This is believed to be from the homeostatic response of the body to the constant presence of the benzodiazepines. When those who have benzodiazepine neuroadaptation try to stop a benzodiazepine, the nervous system can go into a chronic hyperactive state. The taking of the benzodiazepine has made the body unable to properly utilize GABA.

This nervous system reaction can occur on the benzodiazepines, in tolerance withdrawal , when stopping benzodiazepines, or after being completely withdrawn. While the nervous system is in a hyperactive state of tolerance , toxicity, withdrawal, or protracted withdrawal , patients anecdotally report having reactions to certain substances, even if they previously tolerated them, and setbacks from these reactions.

Setbacks and Reactions to Substances

Setback refers to the return of a withdrawal syndrome after improvement or healing. Reaction describes an increase or recurrence of withdrawal symptoms after exposure to a substance. For an example consider a patient who experienced protracted withdrawal syndrome for 2 years post taper. They healed and returned to normal functioning.The patient, after a stressful day, consumed a GABA supplement hoping to relax. Within a few days all of their protracted withdrawal symptoms returned, rendering them bedridden and unable to work again for another 2 years.

Usually, setbacks occur after environmental stresses, according to Dr. Heather Ashton in her 2011 supplement to The Ashton Manual, which can include GABAergic and other substances. Reactions and setbacks can vary from short-lived and mild to severe and long-lasting.

The potential reason(s) for these “reactions” and “setbacks”, as described by Dr. Heather Ashton :

One mechanism which might be involved in long-term (and possibly permanent) effects of benzodiazepines is an alteration in the activity of benzodiazepine receptors in brain GABA neurones. These receptors down-regulate (become fewer) as tolerance to benzodiazepines develop with chronic use. Such down-regulation is a homeostatic response of the body to the constant presence of the drugs. Since benzodiazepines themselves enhance the actions of GABA, extra benzodiazepine receptors are no longer needed, so many are, in effect, discarded. These down-regulated receptors are absorbed into neurones where, over time, they undergo various changes including alterations in gene expression. When these receptors are slowly reinstated after drug withdrawal, they may return in a slightly altered form. They may not be quite so efficient as before in increasing the actions of GABA, the natural ‘calming’ neurotransmitter. As a result, the brain may be generally less sensitive to GABA and the individual is left with heightened central nervous system excitability and increased sensitivity to stress. Molecular biologists point out that changes in gene expression can be very slow, or even unable, to reverse..

It is not unusual to experience recurrence of apparent benzodiazepine withdrawal symptoms years after a successful withdrawal and a return to normal health. This pattern of symptoms is unique to the individual, depending on his physical and psychological makeup, and no doubt on the innate density of his/her benzodiazepine receptors and the balance of his endozepines . The experience of benzodiazepine withdrawal is deeply etched into the mind and memory of those who have been through it. Like all memories, it is actually physically present in the strength and connections of their neural synapses. These recurrent symptoms are all signs of GABA underactivity with its accompanying increased output of excitatory neurotransmitters, resulting in a hyperactive, hypersensitive central nervous system. The mechanism of action is exactly the same as that of benzodiazepine withdrawal, which is why the symptoms are the same.

It is not clear why many people report experiencing adverse effects from new drugs or drugs they have tolerated before taking benzodiazepines. The drugs involved are so disparate – from skin ointments to eye drops to local anaesthetics to antidepressants, steroids and many others – that it is difficult to attribute these reactions to metabolic effects, allergies or other known effects. Presumably the general hypersensitivity of the nervous system magnifies the reaction to any foreign substances, but no clear explanation has yet emerged. An exception is quinolone antibiotics , which displace benzodiazepines from their binding sites and should not be taken by patients on, or recently on, benzodiazepines.

Neurotoxicity

Another explanation for reactions and setbacks might be found by researching neurotoxicity. Neurotoxicity is the capacity of chemical, biological or physical agents to cause adverse functional or structural damage in the nervous system. People with chronic neurotoxic syndromes (sometimes called protracted withdrawal ) often experience chemical sensitivity, even to chemicals they were never sensitive to prior to the exposure to the neurotoxin. Common symptoms of neurotoxicity can include problems with memory, concentration, learning, mental processing speed, sleep, thinking, language, as well as anxiety, depression, confusion, personality changes, fatigue, and numbness of the hands and feet. Many types of nervous system disorders can be caused by neurotoxicity, including numerous neurologic and psychiatric disorders, as well as chemical sensitivity. Some experts compare head injuries to neurotoxicity, as the resulting inflammation and neurotransmitter dysfunction is similar.

Potentially Dangerous Substances List

The following is a list of supplements, medications, etc. which one may wish to avoid during a taper, benzodiazepine cessation, during protracted withdrawal and even after healing, due to the potential for interference with recovery. The list is not all-inclusive. The lists are solely provided for information purposes and not medical advice.

Please also note that some of the drugs and/or supplements listed may have their own withdrawal complications and require a taper.

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Acorus

A petroleum ether extract of Acorus calamus rhizomes enhanced the GABA-induced chloride current through GABA(A) receptors.

ADHD Medications

These include stimulants such as Ritalin, Adderall and the like. These drugs may lower the seizure threshold and also increase anxiety.

Alcohol
Antibiotics: Non-Fluoroquinolone

Per The Ashton Manual , antibiotics for some reason, sometimes seem to aggravate withdrawal symptoms. There are some studies indicating that penicillins are GABA receptor antagonists. Many antibiotics have a structure that mimics GABA.

Anticonvulsants (Some)

Some anticonvulsants have GABAergic activity or a similar mechanism of action to benzodiazepines.

Antipsychotics (Some)

These have been known to cause severe and potentially permanent adverse effects, such as movement disorders known as Tardive Dyskinesia, akathisia and the development of psychosis even in people without a history of psychotic disorders . Some anticonvulsants have GABAergic activity or a similar mechanism of action to benzodiazepines.

Aspartame/Artificial Sugars

Aspartame (α-aspartyl-l-phenylalanine-o-methyl ester), an artificial sweetener, has been linked to behavioral and cognitive problems. Possible neurophysiological symptoms include learning problems, headache, seizure, migraines, irritable moods, anxiety, depression, and insomnia.

Ashwagandha

Ashwagandha is thought to be GABA-mimetic and to interact with sedatives such as Klonopin. Some benzo abusers take ashwagandha to make their benzos more potent. Exhilarin also contains holy basil (similar to Kava Kava or Pentobarbital), bacopa (interacts with benzos), amla fruit and essential basil oil (can lower seizure threshholds).

Baclofen

Baclofen reduces the strength of excitatory (glutamate) and inhibitory (GABA) transmission in the amygdala by a presynaptic mechanism

Bai Shao/Paeonia Lactiflora Pall / Radix Paeniae Albea / White Peony
Caffeine

Caffeine directly interacts with GABA synapses.

Cannabis (Marijuana, CBD oil, THC)

Cannabinoids impact the GABA receptors . CBD and others can impact cytochrome P450, a family of liver enzymes. See: CBD-Drug Interactions: The Role of Cytochrome P450 . The cannabinoid CB1 receptor is involved in the anxiolytic, sedative and amnesic actions of benzodiazepines. Prolonged Cannabinoid Exposure Alters GABA(A) Receptor Mediated Synaptic Function in Cultured Hippocampal Neurons. The major central endocannabinoid directly acts at GABAA receptors. In all its forms, cannabis works with the brain’s GABA pathways just as benzos do. Despite evidence that some endogenous and synthetic cannabinoids interact with GABAA receptors, no-one has yet investigated the effects of CBD.

Chamomile

Chamomile is widely regarded as a mild tranquilizer and sleep-inducer. Sedative effects may be due to the flavonoid, apigenin that binds to benzodiazepine receptors in the brain. Studies in preclinical models have shown anticonvulsant and CNS depressant effects respectively.

China Root/Hoelen/Pachymic Acid/Poria

A study provided evidence for the hypnotic effects as pachymic acid enhanced pentobarbital-induced sleeping behaviors via GABAA-ergic mechanisms in rodents

Clonidine

A study hypothesized that GABA(A) binding sites in the nucleus accumbens form part of the sequence of events that is triggered by clonidine in an alpha2-adrenergic-specific manner and that ultimately results in a decreased release of dopamine in the nucleus accumbens. Another found clonidine enhanced the GABA content in the brain and hypothalamus.

Corticosteroids (all forms)

Glucocorticoids exert an opposing rapid regulation of glutamate and GABA synaptic input.

Corydalis
Dioscorea/Wild Yam

Dioscorea enter s and physically blocks the ion channels normally associated with GABA.

Epinephrine

This is adrenaline and is often found in local anesthetics. Some local anesthetics do not contain epinephrine; ask your doctor. Lidocaine with epinephrine is commonly used for dental procedures. To avoid this, many dental patients will request carbocaine plain/without epinephrine. Lidocaine inhibits GABA(A) currents .

Estrogen
Exhilarin

Exhilarin is thought to be GABA-mimetic and to interact with sedatives such as Klonopin. Some benzo abusers take ashwagandha to make their benzos more potent. Exhilarin also contains holy basil (similar to Kava Kava or Pentobarbital), bacopa (interacts with benzos), amla fruit and essential basil oil (can lower seizure threshholds).

Fluoroquinolone Antibiotics

These antagonize the GABAA receptor and have recently been updated with an FDA Boxed warnings by the FDA regarding risks “due to potentially permanent, disabling side effects occurring together,” such as nerve damage, Myasthenia Gravis, and others. It is important to note as well that the fluoroquinolones actually displace benzodiazepines from their binding sites on GABA-receptors. This class of antibiotics can precipitate acute withdrawal in people taking or tapering from benzodiazepines. It may be necessary to take antibiotics during benzodiazepine withdrawal, but, if possible, the fluoroquinolones should be entirely avoided. Fluoroquinolones should be contraindicated with chronic benzodiazepine exposure in nearly every scenario.

GABA supplements

The problem in benzodiazepine neuroadaptation and withdrawal is not one of a lack of GABA, but one of a lack of receptors to properly utilize GABA. These supplements are not typically useful in general as they don’t cross the blood-brain barrier.

Gabapentin/Lyrica/Neurontin/Pregabalin

These drugs are commonly used even though they have not been proven effective for benzodiazepine cessation. A clinical trial for “GabapentinTreatment of Benzodiazepine Dependence” began in 2013. It was terminated, without results, in 2018. All of these drugs require their own slow taper and have their own severe withdrawal syndromes with corresponding patient support groups .

Ganoderma/Reishi Mushroom

Ganoderma lucidum potentiates pentobarbital-induced sleep via a GABAergic mechanism.

Guaifenesin/Mucinex

Guaifenesin is a centrally acting skeletal muscle relaxant and produces effects similar to the benzodiazepines by binding to specific inhibitory neurotransmitter receptor sites in the brain and spinal cord that are activated by GABA.

LDN or Low-Dose Naltrexone

Naltrexone and its active metabolite 6-β-naltrexol are competitive antagonists at μ-opioid and κ-opioid receptors, and to a lesser extent at δ-opioid receptors. Standard therapeutic doses of naltrexone blocks these receptors, which does two things; it prevents inhibition of GABA receptors (normally, signaling through the GABA receptors inhibits the activity of neurons; many drugs inhibit GABA and thus “free up” neuronal activation; preventing inhibition of GABA allows GABA’s normal inhibition activity to take place) and it blocks dopamine release.

Jujube Fruit/Ziziphus Jujuba

The results of a study showed that GABA is present in jujube fruit, in a relatively high amount, as measured by the present method.

Kava/Piper Methysticum

Kava, like many of these herbs, has a multi-faceted and complicated mode of action. Some research suggests that it may be a positive allosteric modulator of the GABA receptor , like benzos.

Lemon Balm/Melissa Officinalis

Prevents the breakdown of GABA by being a potent inhibitor of the enzyme GABA transaminase.

Lidocaine

Both lidocaine and procaine at high concentrations inhibited GABA(A) receptor currents, whereas neither lidocaine nor procaine affected GABA(C) receptor function.

L-Theanine

L-Theanine is found in a lot of calming supplements like Zen Mind Progesterone medicines and creams. It increases GABA.

Magnesium
Magnolia

Magnolia may have anxiolytic-like effects and that these effects may be mediated by GABAergic transmission with the increase of Cl(-) channel opening.

Melatonin

Melatonin increased levels of GABA in an animal study.

Monosodium Glutamate (MSG) and Other Preservatives

Two-step biotr a nsformation of monosodium glutamate to GABA.

Nasal Decongestants

Decongestants increase adrenaline which may increase anxiety.

NSAIDs

During the preparation of DRG neurons harvested from Sprague-Dawley rats, the whole-cell recording technique was used to record the effect of NSAIDs on GABA-activated inward currents, and the expression levels of the TMEM16A and TMEM16B subunits were revealed.

Opiates

FDA black box warning interaction for opiates and benzodiazepines. Increased risk of respiratory depression when combined with other drugs. This combination can lead to death .
Exogenous opioids attach to mu receptors , reducing the amount of GABA released.

Oregano Oil

Oregano Oil is thought to be involved in the GABAergic system. This recorded interview is an account given by a caregiver to someone with benzodiazepine harmed patient who experienced a severe setback from Oregano oil applied directly to the skin. Note that oregano oil can be found in food.

Passionflower/Passiflora Incarnata

According to animal studies, a high potency passionflower extract has an anxiolytic effect comparable to diazepam .

Penicillin

Penicillin probably exerts its proconvulsant effect by inhibiting GABA-gated chloride ion influx . However, it appears not to act through the BZ receptor of the GABA/BZ receptor complex.

Phenibut

Phenibut acts as a GABA-mimetic , primarily at GABA(B) and, to some extent, at GABA(A) receptors. Phenibut (beta-phenyl-gamma-aminobutyric acid HCl)

Picamilon

One study in animals showed that picamilon permeated the blood–brain barrier and then is hydrolyzed into GABA and niacin. The released GABA in theory would activate GABA receptors potentially producing an anxiolytic response.

Polygala

Polygala acts as a GABA(A) agonist.

Progesterone
Pseudoephedrine

This and other stimulating additives in over-the-counter cough and congestion remedies may cause increased anxiety.

Pueraria
Quinine

Antimalarial drugs inhibit GABA(a).

Soma/Carisprodol

Soma/carisoprodol is a muscle relaxant. However, a metabolite of carisoprodol, meprobamate, has anxiolytic and sedative properties .

Saffron Extract/Safranal

Saffron Extract has anticonvulsant properties. It has been shown to act as an agonist at GABA(A) receptors.

Salvia Officinalis

The Salvia officinalis extract replaced 50% of specific ligand binding to GABA(A) and GABA(B) receptor.

Schisandra

Up-regulates the expression of GABA(A)

Scullcap (scutellaria)

Scullcap has been used traditionally as an anxiolytic and sedative. It has a number of flavones that have been reported to selectively bind with high affinity to central benzodiazepine receptor sites.

SSRIs/SNRIs

Some other medications typically used in anxiety disorders—such as SSRIs and SNRIs for example—can be stimulating to the central nervous system, and people with a history of benzodiazepine physical dependence, withdrawal and central nervous system damage may be more sensitive to their adverse effects. These other medications may cause further hyperexcitability in the already sensitized nervous system of a person harmed by benzodiazepines. Antidepressant sensitivity is more common in younger people and females , and the increase in anxiety caused by an antidepressant can result in a higher risk of suicide . For these reasons, initiating antidepressant therapy in someone suffering from benzodiazepine withdrawal or damage, and those who are benzodiazepine-sensitized or with a sensitive constitution in general should be approached with extreme caution, if attempted at all.

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Testosterone

Testosterone impacts GABA+ levels in the posterior-cingulate in unmedicated depressed women during reproductive life.

Valerian

( Valeriana spp.) is widely used as an herbal sedative. Its exact method of action is still unknown, although it affects the GABA system . It contains a wide range of constituents, including alkaloids, valeric acid (which is similar in structure to both GABA and GHB), valerenic acid (which may bind to serotonin receptors), and even GABA itself. Additionally, valerian has been shown to stimulate an enzyme called glutamate decarboxylase (GAD) which creates GABA from glutamate in the brain.

Wellbutrin/Bupropion

This medication is often prescribed as a smoking cessation aid or antidepressant. It is not approved for anxiety or depression with anxiety as a comorbidity and can worsen anxiety. This medication can also lower the seizure threshold. Manufacturer’s guidelines warn: “You should not take Wellbutrin if you have seizures, an eating disorder, or if you have suddenly stopped using alcohol, seizure medication, or sedatives.” Serious adverse effects of this medication may include “suicidal thoughts, anxiety, agitation, seizure, mania, high blood pressure, and liver damage”.

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How People Are Kicking Xanax Addiction With CBD

Xanax (benzodiazepine) addiction is a major problem worldwide. Many people are starting to turn to CBD as a means of weaning themselves off benzodiazepines.

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Xanax is a brand-name anti-anxiety medication in the benzodiazepine class of drugs.

It is used to force the nervous system into a relaxed state — effectively stopping anxiety in its tracks.

The problem with benzodiazepines, in general, is that they’re highly addictive. After just a few weeks of use, people may become dependent on them. As soon as the effects wear off, the brain goes into a state of hyperactivation — resulting in severe anxiety attacks. This can lead to debilitating insomnia and emotional instability.

Because of the severe side effects, many people are trying to get off benzodiazepines but find it difficult because of their highly addictive nature. When the drugs disappear from the system, users can be faced with disabling anxiety attacks.

People are turning to cannabidiol (CBD) as a way to alleviate withdrawal symptoms while they reduce their dose of benzodiazepines. The goal is to stop using them altogether.

In this article, we’ll discuss how people are using CBD as an intermediary to wean themselves safely off benzodiazepines such as Xanax. We’ll talk about the promising research being done in this area and what it means for people hooked on anxiety medications.

Let’s get started.

Table of Contents

What are Benzodiazepines?

Benzodiazepines are a class of synthetic anti-anxiety medications.

This class of medications is used for treating anxiety disorders (such as social anxiety disorder, generalized anxiety disorder, and panic disorder) and insomnia.

Some of the most popular brands include Xanax, Valium, Klonopin, and Lorazepam.

Xanax is by far the most common. Recent reports suggest Xanax is the third most prescribed medication in the United States and one of the top 20 prescription medications sold on the black market globally.

Unfortunately, all benzodiazepines are highly addictive — causing tolerance and dependency on the drug in as little as two weeks of regular use.

List of Benzodiazepines

How Benzodiazepines Work

These potent pharmaceuticals work by modifying the GABA receptors in the brain to become more receptive to GABA. We use GABA to control our stress levels and brain activity. The best analogy for GABA is that it behaves like the brake pedal for the brain — slowing us down when we need to stop.

When GABA activity increases, it slows nerve transmissions in the brain — making us feel relaxed. This stops anxiety attacks in their tracks and calms us down enough to fall asleep.

Problems with Benzodiazepines

1. Addiction

Most people start taking Xanax or other benzodiazepines without expecting to become addicted. Doctors prescribe the medication in small doses for short periods to help people get through periods of severe anxiety. Benzodiazepines are also prescribed for periods of insomnia as they provide short-term relief.

The problem with this is that it only takes a few doses to cause addiction.

After just a few days, the body starts to resist the effects of the drug. It does this by changing the GABA receptors. As this change happens, users need to take higher doses of the drug to produce the same results.

At the same time, our natural GABA levels struggle as well. We can’t produce more GABA to make up for the tolerance, so, instead, we experience side-effects from the poor GABA function. The main side effect of this is the very thing the drugs were intended to treat — anxiety.

Benzodiazepine addiction is characterized by the onset of negative side effects as the drugs wear off. This is called withdrawal.

Withdrawal on benzodiazepines is extremely unpleasant. It includes symptoms such as:

  • Severe anxiety and panic attacks
  • Insomnia
  • Mood disturbances
  • Muscle tremors
  • Muscle pain
  • Suicidal thoughts
  • Nausea and vomiting
  • Sweating
  • Weight loss
  • Seizures
  • Death (with severe benzodiazepine addiction)

As the side effects of anxiety appear, it’s difficult for people to resist the medication. The drug is the only thing that will stop it. This is a nearly impossibly high obstacle to manoeuver when in the process of quitting the drug.

Therefore, most people continue taking the drug despite its negative side effects. The anxiety is just too intense without it.

2. Overdose

Benzodiazepines themselves don’t usually cause an overdose. However, when combined with other drugs such as opiate painkillers or alcohol, the mix can be incredibly dangerous.

Michael Jackson and rapper Lil Peep both had Xanax in their systems at the time of their deaths.

Users think they can avoid these issues by merely sticking to benzodiazepines and avoiding opiates or alcohol — but it’s not this simple.

Doctors won’t continue writing prescriptions for the drug indefinitely, and if they do, they will cap the dose. As tolerance increases, users are forced to seek out other sources of the drug to feed their addiction.

However, black market benzodiazepines aren’t always made using good manufacturing processes. A lot of them contain a mix of other drugs, such as fentanyl, to cut costs for the manufacturer. This is extremely dangerous and all too common.

All it takes is one bad pill to end up like Lil Peep — who died from taking Xanax laced with fentanyl.

If Lil Peep can’t even get clean drugs, what makes you think you can?

Suggested Reading: Can You Overdose on CBD?

How Can CBD Help Someone Wean Off Benzodiazepines?

So, now that we have a good understanding of how benzodiazepines work and what makes them so dangerous, we can get into how people are using CBD to support their recovery.

The basic idea is that we can use CBD to wean off benzodiazepines gradually. As the dose of your benzodiazepines is lowered, you can simultaneously increase the dose of CBD to offset some of the side effects.

Once the benzodiazepines are fully removed from the system, the focus is to stop the CBD — which is significantly easier.

This works because CBD has similar effects on the GABA receptors to benzodiazepines — only with significantly less potency and potential for addiction.

CBD also offers other benefits for people suffering benzodiazepine withdrawals:

  1. Anti-convulsant — CBD relieves muscle tremors and tension, helping to reduce this uncomfortable side effect while going through benzodiazepine withdrawal.
  2. Anti-anxiety — one of the most important benefits of CBD is its ability to reduce anxiety symptoms, which, of course, is the primary side-effect of benzodiazepine withdrawal.
  3. Sedative — CBD is a mild sedative, helping to relieve symptoms of insomnia resulting from Xanax, Trazodone, or Valium withdrawals.
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How to Wean Off Benzodiazepines with CBD

Weaning off benzodiazepines with CBD is reasonably straightforward. You start with a low dose of CBD and your regular dose of benzodiazepines. Over time, the dose of benzodiazepines is gradually reduced, while the dose of CBD is steadily increased.

Eventually, the benzodiazepines are stopped completely. Once this stage is reached, the CBD is gradually reduced as well — which is significantly easier and much safer.

Step 1: Tell Your Doctor

Before you stop taking your medication, tell your doctor.

You need to discuss the plan with them even if they don’t approve (many doctors appear to prefer to keep their patients on the medications to avoid withdrawals).

Ultimately, however, your health is your responsibility. If you’re persistent with your doctor, they will need to help you wean off the medication. They’ll give some advice on a plan, along with some tips for getting through the worst of it.

Most doctors will also schedule visits throughout the process to monitor how the body is responding.

Step 2: Make a Dosage Plan

This step should be done with your doctor or another qualified practitioner. Some doctors and naturopaths specialize in weaning off drug addictions. If you can find one of these specialists, we highly recommend using their services to optimize success.

Here’s a simple dosage plan to give you an idea of what it might look like:
Week Xanax Dose (Daily) CBD Dose (Daily)
Week 1 6 mg 0 mg
Week 2 6 mg 5 mg
Week 3 5 mg 15 mg
Week 4 5 mg 30 mg
Week 5 4 mg 40 mg
Week 6 4 mg 50 mg
Week 7 3 mg 55 mg
Week 8 3 mg 55 mg
Week 9 2 mg 60 mg
Week 10 2 mg 60 mg
Week 11 1 mg 60 mg
Week 12 0 mg 60 mg

These dosages can vary significantly depending on your daily dose of Xanax or other benzodiazepines and how your body reacts to CBD. Some people need higher doses of CBD to be effective; others need lower doses.

You can try out our CBD Dosage Calculator to estimate your ideal dosage to begin.

The key to using CBD is to start low and build up gradually until you get the desired effects. You may need to increase the dose slightly when you lower the benzodiazepine dose.

Step 3: Order Your CBD

Before you start the weaning-off process, make sure you have enough CBD to get through the first couple of weeks. We recommend opting for a high-potency product — this can always be diluted to smaller doses, but it can be hard to hit higher doses with low-potency products.

We recommend finding a decent CBD oil and a CBD vaporizer. Oils offer long-lasting effects that can be taken both first things in the morning and in the afternoon or evening.

Vaping is good for spot treatment whenever withdrawal symptoms start and for eliminating the habit of popping pills whenever anxiety appears.

You could also check out the best CBD gummies for anxiety relief. Gummies are discrete and easy to take on the go.

Tips for Using CBD for Benzodiazepine Addiction

1. Seek Professional Medical Help Before Attempting the Weaning-Off Process

First and foremost, whenever stopping a medication such as a benzodiazepine, you need to seek out medical advice from a qualified doctor.

Benzodiazepine withdrawals can be dangerous — even lethal, in some cases.

Consult your doctor and return for follow-up visits every time you reduce your benzodiazepine dose so the doctor can assess your vital signs periodically as well as your overall wellbeing and emotional health.

2. Wean Off Benzodiazepines Slowly

It’s better to wean off benzodiazepines slowly over a few weeks instead of as fast as possible — this is especially true for people with a history of using benzodiazepines for more than six months.

Reducing your dose too quickly increases the chances of severe panic attacks, which can lead to a relapse. Instead, plan to wean down by roughly 25% every two weeks.

A good schedule is to lower the dose by about 1 mg every second or third week.

This gives the body enough time to readjust its dependency on the new dose. Once the body has stabilized, you can move on to the next stage and start the process again.

3. Perseverance is Key to Success

Even with the help of CBD, getting off benzodiazepines can be a challenge. Although CBD can significantly improve withdrawal symptoms, it won’t eliminate them.

It’s essential to persevere through periods where withdrawal symptoms can become especially challenging. Remember that the discomfort will eventually pass for good, but only if the process is seen through to the end.

4. Use the Right CBD Products

There are a lot of CBD products on the market — many of which are not going to be sufficient enough for this application.

Look for a CBD product that has the following characteristics:

Using cheap, poor-quality CBD products may be ineffective or, in some cases, make symptoms even worse. This is especially true with contaminants such as pesticides and heavy metals — which can cause anxiety. This is the last thing you want when going through benzodiazepines withdrawal.

We also highly recommend opting for a full-spectrum extract. The full combination of cannabinoids, terpenes, and other phytochemicals in the cannabis plant is more beneficial than CBD in isolation [1].

5. Consider Vaping

Rarely do we recommend anyone starts vaping, especially if they’re not already a smoker.

However, in this case, vaping is very beneficial for changing habits of drug use.

The very action of vaping can help users change habits in their brains. Usually, when benzodiazepine users feel anxiety coming on between doses, they’ll reach for a pill. This forms habit pathways in the brain that can be hard to shake.

This habit of popping pills for anxiety can be replaced with a few hits from a vape instead.

Of course, you don’t want to have compulsive or addictive behavior with anything, including vaping — but during the process of weaning off benzodiazepines, this can be a game-changer.

Vaping also offers the benefits of being fast-acting — especially compared with things such as CBD oils or capsules that can take as long as 45 minutes to start producing their effects. Vaping only takes 5 to 15 minutes to produce the same results.

When anxiety attacks come on, they come on quickly, so relief also needs to be felt rapidly.

6. Use Multiple Forms of Treatments Together

As with any complex medical condition, the best treatment is a multifaceted approach rather than one form of treatment.

Doctors working in rehabilitation centers treating patients for addiction have a variety of techniques at their disposal. It’s the same for people working on correcting addiction at home.

Some common techniques people use to get through benzodiazepine withdrawal may include:

  • Support groups
  • Other herbs
  • Nutritional support
  • Dietary changes
  • Removal of common triggers for drug use
  • Starting a new hobby

What the Research Says

One of the most well-researched benefits of CBD is its anti-anxiety effects.

Interestingly, much of this benefit of CBD is through its activity on the benzodiazepine receptors themselves [2, 3].

This means two things:

  1. CBD can be used to replace benzodiazepines to help wean off the drug.
  2. CBD may increase the effects of benzodiazepines — making it essential to start at a low dose and build up gradually.

A retrospective study published in 2019 analyzed a cohort of 146 medical marijuana patients who were also taking benzodiazepines at the start of the study [4]. By the end of the two-month study, 30% of these patients were no longer taking benzodiazepines. A later follow-up at the six-month mark found that 45% of the patients that took part in the study were off benzodiazepines completely.

Key Takeaways: Weaning Off Benzodiazepines with CBD

Benzodiazepines are posing a significant problem around the world. In the short term, these drugs are incredibly useful for eliminating severe anxiety and panic disorders. However, long-term use can result in addiction. Stopping the medication for any reason causes withdrawal symptoms, which can be excruciating.

CBD is a useful supplement for supporting the recovery process. It has similar effects on benzodiazepine medications, which help alleviate the withdrawal symptoms. In addition, CBD extracts have other benefits that can be used to make the withdrawal process more comfortable — therefore, improving the chances of successful recovery.

Of course, whenever trying something like this, it’s essential to seek medical counsel first. Your doctor should be on board with your plan to stop the medication and will help you form a weaning-off plan — gradually decreasing the benzodiazepine doses while increasing the dose of CBD.

This study was retrospective, looking at the relationship between benzodiazepine use and cannabis use. The original study didn’t look at the effects of weaning off benzodiazepines with cannabis or CBD specifically. The results are likely to be much higher if the intent is to get off the benzodiazepines.