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Comparison shopping for cbd oil

10 Best CBD Companies to Buy From in 2022: Honest Reviews & Guide

Once an obscure niche product, CBD is now undoubtedly mainstream. Due to a continuing lack of FDA regulation, however, there are no overarching quality standards in the CBD industry.

Consequently, consumers have to determine which CBD products are high-quality and effective. To make it easier for you to choose CBD oil brands that offer the best value and the safest products, we put together this detailed review of the best CBD brands of 2022 and beyond.

Best CBD Companies Ranked

Other Great Brands

  1. CBDistillery
  2. Charlotte’s Web
  3. Lazarus Naturals
  4. Royal CBD
  5. JustCBD

Which Company Has The Best CBD Oil in 2022?

To find the best CBD oil companies on the market, we devised a set of criteria that we applied to each brand that we considered. Leveraging our own expertise and calling upon the insight of industry experts, we determined the value that each brand in our list provides by thoroughly evaluating the following factors:

1. Brand Credibility

  • How adaptive and well-designed was the brand’s website?
  • How well was their site content written?
  • How quickly did they respond to customer inquiries?

These are just a few examples of the variables we used to determine brand credibility.

2. Hemp Source

U.S. hemp is the highest-quality, and using hemp grown in the United States supports the domestic agricultural economy. Brands that used organically grown hemp cultivated in the United States received the highest grades.

We also took into account factors such as whether a brand’s hemp was U.S. hemp authority-certified or non-GMO. At this point, non-GMO hemp is the standard in the industry, so we disqualified brands that used hemp that was genetically modified.

3. Extraction & Purification

There are a variety of solvents that brands can use to extract CBD from hemp. Some of these solvents are difficult to purge from finished products, however, and they can cause respiratory harm.

Carbon dioxide is widely recognized as the safest extraction solvent for hemp. As a result, brands that use CO2 extraction received high scores, while brands that use butane, ethanol, or acetone extraction were penalized.

4. Lab Reports

In lieu of FDA regulation, third-party lab testing has become the gold standard for determining a hemp product’s safety and quality. CBD products that have been third-party lab tested can be verified as not containing contaminants.

However, there are quite a few different third-party lab test providers on the market, and some are less independent than they seem. In addition to making sure that products were tested, we also looked at which company provided the lab tests for each of the hemp brands we examined.

5. Customer Service

You can learn a lot from how a CBD brand handles its customer service. Obviously, customers are better served by brands that respond quickly and offer courteous customer service.

If a CBD brand’s customer service is lackluster, however, that brand might also be lacking in other ways. We checked each brand’s customer service capabilities to determine its overall integrity and attention to detail.

How Our Experts Chose These Criteria

We’re no strangers to the CBD industry. We’ve watched interest in CBD grow over the years, and we’ve observed the highest and lowest points in the industry’s history.

Over time, the experts who put together this guide have had plenty of chances to compare and contrast CBD companies. We’ve seen which companies have risen to the top, and we’ve seen how they achieved these results.

At the same time, we’ve become familiar with the most common points of failure within the CBD industry. We developed our evaluation criteria based on longitudinal research into the brand factors that are most likely to result in high-quality CBD products.

Best CBD Companies: Detailed Reviews

Colorado Botanicals: Best All-Around & Highest Quality

After extensively considering each brand’s benefits and drawbacks, we determined that Colorado Botanicals offers the best products for the most reasonable prices. This brand offers similar product types to major competitors, but it enhances these products’ benefits by tapping into the hemp plant’s true potential.

Brand Credibility

Colorado Botanicals isn’t a household name, but the company more than holds up against its bigger competitors. Every aspect of the Colorado Botanicals brand met our strict criteria for excellence.

  • Clean, simple website with excellent graphics
  • Detailed product information and site content
  • Highly detailed third-party testing reports
  • Broad-spectrum, THC-free CBD products
  • Extensive focus on the benefits of terpenes

Colorado Botanicals also won our top spot for Best CBD Oil and Best CBG Oil of 2022, proving that quality – not famous branding – determines a product’s success.

Extraction & Purification Standards

Colorado Botanicals uses CO2 extraction to produce its Full and Broad-Spectrum CBD oil products. Using an advanced distillation process that leaves terpenes intact while removing all traces of THC, Colorado Botanicals produces high-quality Broad-Spectrum distillate.

This distillate does not contain waxes, chlorophyll, or unnecessary lipids. It has a mild taste that is made even more pleasant by its high terpene content.

Type of CBD

Most of Colorado Botanicals products are Broad Spectrum but they started offering Full Spectrum CBD oils. In contrast with Full-Spectrum CBD oil, this type of purified and refined CBD is entirely THC-free, assuaging potential concerns regarding THC contamination in CBD products.

What’s most impressive about Colorado Botanicals products is their high terpene concentrations. Often overlooked in the CBD industry, terpenes are beneficial substances found in Cannabis sativa that each has unique properties.

Focus on Terpenes

It’s important to note that the terpenes found in Colorado Botanicals Full and Broad-spectrum CBD oil are not reintroduced into the finished product. Instead, they are the original terpenes present in the CBD-rich hemp flower that Colorado Botanicals naturally retains.

Reintroduced terpenes can cause contamination issues, and they don’t provide the same effects as terpenes that are naturally present in CBD extract. We’re impressed that Colorado Botanicals knows the difference and their ability to naturally retain terpenes in its products.

About Terpenes

Why are terpenes so important? Scientists believe that terpenes may contribute to the entourage effect , which is a theorized form of Cannabis sativa synergy that may occur when cannabinoids and terpenes are used together.

Initially believed to primarily apply to interactions between cannabinoids, researchers have now recognized that terpenes may be just as essential to the activation of the entourage effect. CBD products that contain terpenes may be more effective or provide more benefits than products that do not.

Individual Effects of Terpenes

In addition to potentially contributing to the entourage effect, terpenes also have individual benefits. Found in many other plants aside from Cannabis sativa, terpenes have been studied for decades for their potential beneficial effects.

  • Beta-Caryophyllene – Beta-caryophyllene is one of the only terpenes that acts like a cannabinoid. It stimulates the nervous system’s CB2 receptors , which modulate inflammation. Unlike CB1 receptors, CB2 receptors do not cause intoxication. However, these neuroreceptors have dozens of potential beneficial effects aside from their observed impact on inflammation.
  • Humulene – Like most terpenes, humulene has been studied for its potential antioxidant and anti-inflammatory effects. Humulene is also one of a few terpenes that have been researched for their potential antimicrobial benefits .
  • Linalool – Along with humulene, linalool has been studied for its potential antimicrobial and antioxidant benefits . This terpene is found in lavender as well as hemp.
  • Bisabolol – A rare terpene, bisabolol has been studied for its potential ability to reduce skin inflammation , and the antimicrobial potential of this terpene has also been researched.

Terpene Lab Tests

To give you an idea of just how seriously Colorado Botanicals takes terpenes, here are the results from one of this brand’s recent lab tests:

Since testing for terpenes is an added service, most CBD brands fail to determine the exact concentrations of terpenes present in their products. Colorado Botanicals, on the other hand, makes sure that their third-party lab tests contain detailed terpene information.

Price per Milligram of CBD

The price per milligram of CBD varies among Colorado Botanicals products. We’ll use this brand’s 1500mg CBD tincture as a baseline, however, since many brands produce similar tinctures.

This product presently costs $110, so the CBD in this tincture costs $0.073 per milligram. This price is standard within the industry, and Colorado Botanicals tinctures offer added value due to their terpene content.

Lab Reports

Colorado Botanicals lab reports are available in PDF form in a public Google Drive folder that is linked on each product page. They test their products and extracts at FESA Labs and ProVerde Laboratories. They provide detailed information on the cannabinoid, terpene, and contaminant concentrations present in each product.

Customer Support

In our experience, Colorado Botanicals offered excellent customer support. This brand provides a contact form, email address, and phone number you can use to get in touch with customer service.

A representative answered the phone immediately when we called. We received a response to an emailed inquiry on the same day.

Certifications

Colorado Botanicals has received ISO 9001:2015 certification for its production facility. This brand uses cGMP processes to produce its products.

Pros & Cons

Here are the highs and lows of this exemplary CBD brand:

Pros

  • Broad-spectrum, THC-free CBD
  • Offers Full Spectrum CBD Oil now
  • Terpene-rich CBD extract
  • No reintroduced terpenes
  • Reasonable price-per-milligram
  • Detailed lab reports with lab reports page
  • ISO 9001:2015 certification
  • The best customer service we’ve come across in all the audits we did

Cons

  • Products aren’t significantly more affordable than options offered by competitors
  • Shipping is free over $74

Bluebird Botanicals: Best Full-Spectrum

Bluebird Botanicals has been around since 2012, and this brand is still going strong. While the quality of the full-spectrum and CBD isolate products Bluebird Botanicals offers certainly seems satisfactory, we were more impressed by this brand’s prices.

If you’re looking for quality CBD that’s lighter on the wallet, this is probably the best option. Normally, low price a red indicating poor quality. Bluebird Botanicals, however, proves that there are major exceptions to that rule.

Brand Credibility

Any CBD brand that’s been around for more than eight years carries plenty of clout. While the Bluebird Botanicals website was relatively cluttered, it contained plenty of helpful information, and this brand is highly transparent regarding where it sources its hemp and how it produces its products.

Extraction & Purification Standards

Bluebird Botanicals uses a mix of CO2 extraction and ethanol extraction. This brand then uses steam distillation to remove impurities from its extracts. It’s unclear why Bluebird also uses ethanol if this company also has access to CO2 extraction facilities.

Type of CBD

Most of the products Bluebird Botanicals offers include Full-Spectrum CBD. In contrast with Nuleaf, Bluebird uses distillation to remove impurities like chlorophyll from its CBD oil.

However, Bluebird leaves traces of THC behind in its extracts instead of choosing to produce Broad-spectrum CBD. To boost its lineup with THC-free products, Bluebird also provides a few offerings that contain CBD isolate.

Price per Milligram of CBD

Bluebird’s Extra Strength Classic CBD Oil tincture contains 1500mg CBD, and it costs $99.95. As a result, this product’s price-per-milligram is $0.066, making Bluebird Botanicals CBD highly affordable.

Lab Reports

Instead of linking to lab reports on product pages, Bluebird provides them all on a single page, making it difficult to access the report you’re looking for. This brand breaks its third-party lab results into multiple sections, making the process a bit more confusing.

However, Bluebird tests for terpenes, heavy metals, mycotoxins, and a variety of other variables. Even though the reports may be difficult to access, this brand’s lab reports are among the industry’s most thorough.

Customer Support

We found Bluebird’s customer service team to be highly accessible and responsive. This brand provides a contact form, a phone number, and multiple email addresses.

Certifications

Bluebird Botanicals has received a number of certifications, including:

  • B Corporation Certification
  • Leaping Bunny Cruelty-Free Certification
  • U.S. Hemp Authority Certification
  • Glyphosate Residue Free Certification

It does not appear, however, that Bluebird’s production facilities have been ISO certified.

Pros & Cons

Here’s what we liked and disliked about Bluebird Botanicals

Pros

  • An industry veteran with a great reputation
  • Highly certified brand
  • Detailed lab reports
  • Quality products

Cons

  • In THC-free products, CBD isolate is used instead of broad-spectrum CBD
  • Lab reports are hard to find
  • The website is somewhat cluttered

Nuleaf Naturals: Best By Reviews

Full-spectrum CBD can be hit-and-miss, but some CBD users swear by the benefits of Full-spectrum products. With more than 20,000 reviews, Nuleaf Naturals is the most popular provider of Full-spectrum hemp products on the market, and we like the simplicity of this brand’s product lineup.

We noticed positive effects and why it landed so high on the list despite the high cost it comes at.

Brand Credibility

Nuleaf Naturals is highly regarded, and this brand’s website is clean and simple. It’s hard not to feel like a brand has credibility when it has accumulated so many positive customer reviews.

Extraction & Purification Standards

Nuleaf uses CO2 to extract its CBD, further improving our impression of this brand. This brand uses a type of Full-Spectrum oil called winterized CBD, which is more raw than refined.

Type of CBD

Nuleaf Naturals products contain winterized Full-Spectrum CBD, which might appeal to some consumers since it’s so raw and unrefined. Winterized extract, however, contains waxes, chlorophyll, and other substances that might taste unpleasant or impair ingestion.

Price per Milligram of CBD

Nuleaf Naturals offers 1,800mg Full-Spectrum tinctures for $179. As a result, this brand’s CBD costs around $0.099 per milligram, one of the industry’s highest prices.

Lab Reports

Nuleaf’s lab reports are hard to find, and they aren’t product-specific. However, this brand’s third-party testing is provided by Botanacor, a reputable lab.

Customer Support

Nuleaf provides customer support via phone, email, and contact form. Our call was answered immediately since we called during business hours, but it took around 24 hours to receive a response to our email.

Certifications

Nuleaf Naturals doesn’t provide information regarding any certifications this brand might hold.

Pros & Cons

Here are what we considered to be the highs and lows of Nuleaf Naturals:

Pros

  • Offers some of the best full-spectrum CBD on the market
  • Over 20,000 satisfied customer reviews
  • Simple, clean website, & very easy to use
  • Been around for a long time and have built trust

Cons

  • High CBD price per milligram
  • They use Winterized CBD Extract so it isn’t purified like a distillate but winterized extracts do generally contain higher amounts of plant compounds which can be good and bad if not purified properly.
  • Lab results are vague and hard to find

Medterra: Highest Concentration

With more than 5,000 customer reviews, Medterra is one of the nation’s most popular CBD oil brands. The quality of Medterra’s CBD was exceptional, and we did like the cannabinoid content of their oil. They did contain higher amounts of cannabinoids than usually seen in CBD products. However, they didn’t test for terpenes, which doesn’t clarify if their extracts contain the terpene contents like Colorado Botanicals.

When testing out their CBD oil, we did notice it to be one of the most effective ones from this list, hence why we ranked it number 2 out of 10.

Brand Credibility

Medterra is certainly one of the most credible CBD oil brands. This company’s site content is on-point, and Medterra provides plenty of information on each of the products it produces.

Extraction & Purification Standards

Medterra uses CO2 extraction to produce its products. Based on customer reviews and our own research, Medterra CBD is highly purified, and it doesn’t contain any waxes, excess lipids, or chlorophyll.

Type of CBD

Medterra used to offer Full-Spectrum CBD oil products. Nowadays, however, this brand only produces Broad-Spectrum CBD and CBD isolate products.

Price per Milligram of CBD

Medterra offers a 1000mg Broad-Spectrum CBD tincture for $59.99. As a result, this brand provides a CBD price-per-milligram of only $0.059, which is one of the lowest prices found in the industry.

Lab Reports

Third-party lab reports from Green Scientific Labs are easy to find on each Medterra product page. While these reports include results for dozens of solvents and pesticides, they do not include results for terpenes.

Unfortunately, it does not appear that Medterra takes the benefits of terpenes very seriously. This lamentable perspective is also clear to see in Medterra’s CBD isolate products, which don’t contain any terpenes whatsoever.

Customer Support

Medterra offers a live chat service. In our experience, however, customer service agents are rarely available for live chat. Instead, customers can contact Medterra by phone, email, or contact form.

Certifications

Medterra products are U.S. hemp authority-certified. However, this brand does not provide any information certifications it may have achieved for its production facilities.

Pros & Cons

Here are the key advantages and disadvantages of Medterra’s products:

Pros

  • Affordable products
  • Over 5,000 customer reviews
  • Easily accessible lab reports
  • Ultra Broad Spectrum CBD Oil has great cannabinoid profile
  • Offers Immune Boost CBD Oil that holds other ingredients

Cons

  • The benefits of terpenes are overlooked
  • Somewhat cluttered product catalog

cbdMD: Best Price

cbdMD is known for its prominent partnerships with athletes and other celebrities. The cbdMD website is remarkably well-built, and this brand produces informative content.

This brand’s products are pretty decent. But while it may not stack up to the above vendors, cbdMD still offers the best price we’ve seen so far. cbdMD also beats its competitors in terms of potency, with up to 7,500mg of CBD in a 30mL bottle.

Brand Credibility

cbdMD operates one of the best CBD eCommerce websites we’ve seen. This brand’s site loads quickly, and it’s full of informative content.

Extraction & Purification Standards

cbdMD uses CO2 extraction to produce its crude hemp extracts. While cbdMD doesn’t provide any information directly stating how it refines its extracts, we assume that this brand uses steam distillation.

Type of CBD

cbdMD products contain Broad-Spectrum CBD extract, though it’s hard to discover this fact without considerable research. This brand sources its hemp from farms located in the United States.

Price per Milligram of CBD

cbdMD offers a 1500mg tincture for $99.99. As a result, this product has a price-per-milligram of $0.067, which is relatively standard within the industry.

Lab Reports

We were very impressed with the procedure cbdMD uses to provide lab reports to consumers. First of all, this brand’s lab reports are conducted by SC Laboratories, one of the nation’s most respected independent labs.

There’s a huge, highlighted button on every product page that you can use to load cbdMD’s lab reports. These reports appear as a popup window, and there are buttons you can use to either download or print the lab report for a particular product.

cbdMD’s lab reports are remarkably detailed, but they reveal that this brand’s products don’t contain considerable concentrations of terpenes. We wish that cbdMD provided lab report archives, not just the results of the latest test.

Customer Support

cbdMD customer support is reachable by live chat, email, contact form, and phone. We found cbdMD’s email support agents to be responsive and helpful.

Certifications

In 2020, cbdMD received NSF International Good Manufacturing Practice (GMP) registration. This certification confirms that cbdMD’s production facilities adhere to the latest cGMP standards. cbdMD is also a member of the U.S. Hemp Roundtable.

Pros & Cons

Here’s a brief summary of the highs and lows of cbdMD:

Pros

  • Big, professional brand with a well-designed website
  • Reasonably priced products
  • Excellent, informative lab reports
  • Wide variety of products to choose from

Cons

  • We didn’t find the pet products to be effective as other pet products we’ve reviewed in the past

Honorable Mentions: Other Great CBD Brands

CBDistillery

We’ve been fans of CBDistillery ever since this brand only offered CBD isolate. Some things about CBDistillery have certainly improved over the years.

In terms of the quality and effectiveness of their oil, we found it effective but not quite enough to be at the top of this list, However, it is a great company to consider purchasing and trying.

Brand Credibility

In our opinion, CBDistillery is a credible company and is well-known in the CBD industry. One thing we noticed is that their lab reports were not easily accessible – they promote third-party testing as a priority.

At the same time, CBDistillery’s website is remarkably responsive and well-designed, and it’s populated with elegant, convincing content. CBDistillery is certainly one of the nation’s biggest CBD companies, which has forced this brand to be reasonably accountable.

Extraction & Purification Standards

CBDistillery uses CO2 extraction to produce its crude CBD extracts. Then, this brand uses steam distillation to produce high-purity isolates and distillates.

Type of CBD

CBDistillery offers a wide selection of Full-Spectrum, Broad-Spectrum, and Isolate CBD products. This brand’s catalog is well-rounded, but CBDistillery offers so many different products that it can be hard to zero in on an ideal formulation.

Price per Milligram of CBD

CBDistillery offers a 1000mg full-spectrum CBD tincture for $60. As a result, the price-per-milligram for this product is $0.06. Like most brands, CBDistillery progressively discounts its higher-dosage products.

Lab Reports

We were unable to find CBDistillery’s lab reports. While this brand claims its products are third-party lab tested, we couldn’t find them with a Google search.

Customer Support

CBDistillery offers a live chat, and this brand is also available by phone and contact form. We found CBDistillery’s customer support to be relatively engaging and responsive.

Certifications

We weren’t able to find any information on certifications that CBDistillery might possess.

Pros & Cons

Let’s summarize the high and low points of CBDistillery:

Pros

  • Veteran brand that has expanded significantly
  • Lots of product options
  • Competitive price-per-milligram
  • Great information easily accessible on their website for new CBD users who wouldn’t mind reading up on them

Cons

  • You have to complete a “Money-Back Guarantee Form” in order to get a refund
  • Third-party lab reports were missing

Charlotte’s Web

Charlotte’s Web rose to fame as one of the first CBD companies to directly target childhood epilepsy. Launched in 2011 as one of the earliest CBD brands, they became popular after helping a little girl named Charlotte Figi. She suffered from Dravet Syndrome, which is a rare form of epilepsy.

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Her first seizure occurred when she was just three months old, which was said to have lasted a full 30 minutes. As she grew older, it worsened with multiple seizures per day, and doctors told the parents there was nothing they could do.

Or was there? When the family became introduced to cannabis and CBD, Charlotte’s Web owners, the Stanley brothers, who owned a cannabis dispensary, began supplying products to their family.

Charlotte Figi, who suffered from life-threatening seizures, saw considerable changes in her body as she continued to use the cannabis extract oil that the Stanley Brothers produced. Soon after seeing the positive impact it had on her life, the brothers decided to change the name to Charlotte’s Web in honor of her.

As CBD regulations have evolved, Charlotte’s Web has pivoted to offer a wide range of general-purpose CBD products.

In terms of their CBD oil and products’ quality, we didn’t find it as effective as the other brands listed here. They have a vast customer base and long-time customers, but we think that their customers will move over to other brands if they don’t improve their extracts’ quality.

Their CBD gummies did taste amazing, and we’re one of the more effective CBD gummies we’ve tried. If you’re looking for good-quality sleep gummies with melatonin, then we would highly recommend giving theirs a try.

Brand Credibility

At a glance, Charlotte’s Web website is well-built and content-rich. Charlotte’s Web bills itself as “the world’s most trusted hemp extract,” but it’s unclear whether this brand is also the world’s most trustworthy CBD producer.

Extraction & Purification Standards

Charlotte’s Web uses a combination of CO2 and isopropyl alcohol extraction techniques. It’s unclear why this brand doesn’t simply stick to CO2 extraction, which is cleaner and more reliable.

Type of CBD

Charlotte’s Web products include Full-Spectrum CBD extract. This brand doesn’t provide any information regarding whether its extracts are distilled or crude.

Price per Milligram of CBD

Charlotte’s Web uses creative measurements that make it relatively difficult to determine how much CBD is contained in each bottle of this brand’s tincture. However, after running some calculations, we’ve determined that Charlotte’s Web offers an 1800mg tincture for $119.99, which is priced fairly.

As a result, this product offers a price-per-milligram of $0.067. This price is standard.

Lab Reports

Charlotte’s Web makes it difficult to access lab reports for its products. You have to input the lot number for your product, which is only available on the product’s outer packaging. If you’re trying to look at their lab reports to help determine if you want to purchase over another brand, you won’t be able to.

Furthermore, Charlotte’s Web does its own in-house lab testing. Charlotte’s Web is the only major CBD brand we’re aware of that breaks from conventional testing in this way.

Customer Support

Charlotte’s Web customer service was reasonably responsive. You can contact this brand via live chat, contact form, or phone.

Certifications

Charlotte’s Web is a certified B Corporation.

Pros & Cons

Let’s summarize the best and worst aspects of Charlotte’s Web:

Pros

  • Reasonably priced products
  • Certified B Corp
  • Wide variety of products to choose from including Sleep Gummies, Recovery Gummies, & Calm Gummies.
  • Sleep gummies we’re very effective

Cons

  • No third-party lab reports, and lab reports are very difficult to access
  • Mixture of isopropyl alcohol and CO2 extraction methods
  • Long shipping times

Lazarus Naturals

There’s a lot we like about Lazarus Naturals. This brand exudes a down-to-earth, working-class mystique, and it features high-quality, organic products that appeal to sustainability-conscious consumers.

At the same time, Lazarus Naturals’ headlong focus on wholesale relationships has allowed this brand’s direct-to-consumer side of operations to suffer. The Lazarus Naturals website is relatively slow, and it’s hard to find pertinent information on this company’s products.

In terms of the quality of their CBD oil, we found it to be effective. They also have many long-time loyal customers, which explains a lot.

Brand Credibility

As a major CBD brand, Lazarus Naturals can’t help but be reasonably credible. Most of this brand’s products have a few dozen reviews, and the content featured on lazarusnaturals.com is convincing. We wish that Lazarus would make its product catalog more accessible to consumers.

Extraction & Purification Standards

Lazarus Naturals uses ethanol to produce its crude CBD extract, which is a low-cost option that many brands opt for. From there, this brand uses steam distillation to remove residual solvents, chlorophyll, and other undesirable substances.

Ethanol extraction is inferior to CO2 extraction.

Type of CBD

Lazarus Naturals offers a wide range of full-spectrum and CBD isolate products. The fact that this company does not offer any Broad-Spectrum CBD products casts doubt on the thoroughness of its extract purification process.

With modern distillation methods, it’s relatively easy to make broad-spectrum CBD. It’s possible that Lazarus is using an outdated form of distillation that might offer decreased product purity.

Price per Milligram of CBD

Lazarus Naturals offers a 15ml, 750mg CBD isolate tincture for only $24. This brand is kind enough to provide the price-per-milligram for this product directly on its product page: $0.032.

That’s one of the lowest, if not the lowest price-per-milligram we’ve ever seen. Rather than inspiring confidence, this rock-bottom price makes us wonder what Lazarus Naturals is sacrificing to keep costs so low.

Lab Reports

Third-party lab reports for Lazarus Naturals products are easy to find on every product page. This brand’s lab reports are provided by Columbia Laboratories, a little-known Portland, OR, analytics lab.

Customer Support

Lazarus Naturals is easy to reach by phone or email. We found this brand’s customer service agents to be responsive and helpful.

Certifications

Lazarus Naturals recently upgraded to a 40,000 square foot production facility in Portland. This brand’s new facility is cGMP-certified.

Lazarus Naturals products are also certified kosher. This is a step that other brands usually choose not to take even though almost all CBD products are inherently kosher.

Pros & Cons

Here’s a brief summary of the best and worst aspects of Lazarus Naturals:

Pros

  • Focus on sustainability and organic ingredients
  • Lab tests are third-party, recent, and easy to find
  • Price-per-milligram is very low

Cons

  • Website is relatively cluttered and difficult to navigate
  • Indirect evidence suggests that purification methods may be sub-par

Royal CBD

One of the first things you’ll see on Royal CBD’s website is “no room for mediocrity.” It’s a catchy and intense slogan that the vendor strictly follows.

An excellent source of Full-Spectrum and Broad-Spectrum CBD products, the company sources its extracts from organic, non-GMO hemp.

Brand Credibility

Royal CBD has a smaller online presence than bigger players like Lazarus Naturals or cbdMD. Still, the company boasts a respectable 2700 customer reviews listed on its website.

Royal CBD also deserves points for its well-written blog filled with plenty of relevant information for new CBD users. This resource undoubtedly makes it easier to choose the right product.

Extraction & Purification Standards

Royal CBD uses CO2 extraction to make its products, which leaves behind no trace solvents. But purity always starts at the source, which is why Royal gets its extracts from organically-grown, non-GMO Colorado hemp.

Type of CBD

Royal CBD exclusively offers full-spectrum CBD oils. However, they offer a Broad-Spectrum extract option in their line of gummies.

Price per Milligram of CBD

Royal CBD is one of the priciest brands we’ve seen (although there are some reasons why this is justified). Still, it’s a substantial investment.

For example, their highest concentration of 2500mg offers the best value per milligram. Although currently on sale for $229.00 as of the writing of this review, the original retail price is $289.00. This translates to about $0.12/mg.

That’s a huge price difference, considering our leading choice, Colorado Botanicals, sells a 3,000mg tincture for $199.99, or about $0.07/mg.

Lab Reports

Royal CBD repeatedly states that they perform third-party lab tests available to the public. However, after searching the site’s product pages, FAQ, and navigation tabs – along with a separate Google search – no links to these alleged results were listed.

Customer Support

Royal CBD offers customer support through phone or a generic contact form. Having a chat feature, however, would be helpful for quick, convenient answers.

Certifications

No information is available about any certifications or professional memberships Royal CBD may have.

Pros & Cons

Like all vendors, Royal CBD excels in some areas more than others.

Pros

  • Up to 83mg/ml
  • Organic
  • CO2 extracted
  • 15% subscription discount

Cons

  • Unable to find third-party lab reports
  • Terpenes are added after extraction
  • Very expensive compared to other CBD brands

JustCBD

“JustCBD” is a bit of a misnomer, given that the company offers the biggest variety of CBD products on our list. Aside from oils, creams, capsules, and edibles, JustCBD also sells products like vape juice and cartridges; bath bombs, honey sticks, and the new (albeit controversial) delta-8 THC.

It’s clear that, while the other companies on our list are health-focused, JustCBD caters to a broader audience with a range of therapeutic goals and strategies.

Brand Credibility

JustCBD doesn’t have a huge presence in the CBD community. However, it still has plenty of valuable blog posts with useful CBD-related guides and information. Unfortunately, we did catch them using Wikipedia as a source to describe the entourage effect in their FAQ section. On the other hand, we noticed some of their content is reviewed by a licensed medical doctor.

Extraction & Purification Standards

Extraction methods depend on the product. JustCBD’s Full-Spectrum oils use CO2 extraction. Their tinctures, on the other hand, are processed using alcohol to make them soluble with food and drinks.

Type of CBD

JustCBD offers two liquid options. Customers can choose between two CBD tinctures and a single Full-Spectrum CBD oil product.

Price per Milligram of CBD

JustCBD provides some of the best value on the market. Their 5,000mg 60oz bottle offers the highest concentration, at 83mg/ml.

With a retail price of only $144.99, this Full-Spectrum oil comes to about $0.01/mg. If you take advantage of their 30% discount on repeat orders, the price per milligram dips down to a fraction of a penny.

Lab Reports

JustCBD third-party tests its products. You can quickly find the results using your oil’s batch/lot number. There’s also the option to search by product category.

Customer Support

Clients can contact Customer Care through e-mail or phone. There isn’t a lot of information about the caliber of their service. But the handful of reviews on Trustpilot are mostly positive, with a couple of bad experiences.

Certifications

No information is available about any certifications or professional memberships.

Pros & Cons

JustCBD has a long way to go, with some strong selling points and a few opportunities for improvement.

Pros

  • 30% discount on repeat orders
  • Organic
  • CO2 extracted (full-spectrum oil)
  • Cheaper than any CBD product so far
  • Third-party tested

Cons

  • Offers delta-8 THC, which has been criticized by medical experts for its toxic extraction process
  • Has been the subject of two class-action lawsuits

How Our Experts Chose the Best CBD Oil Brands of 2022

Toward the start of our guide, we provided some basic information on how we chose the criteria we used to grade each of the brands we examined. Then, with each brand review, we provided more detail on what made particular brands stand out and receive high grades.

We need to go into a little more detail, though, regarding how we came across and ended up choosing the winners in our list. Let’s examine the various methods that our experts used to find out which CBD oil brands offer the best products in the industry:

Customer Reviews

We’ve seen hemp companies brag that they offer the best CBD in existence. We’ve come across almost ludicrously arrogant marketing material and claims that couldn’t possibly be true.

That’s how we learned that sometimes, you need to take a look at reviews from actual customers to determine the quality of a CBD product. We’ll be honest, however, not even customer reviews are perfect.

Selective Reviewing

Unlike eCommerce giants like Amazon and Walmart, which are managed by third parties, CBD brands operate their own eCommerce websites. As a result, they’re able to remove reviews they don’t like.

  • The overall number of reviews a CBD product has received
  • Common themes listed in reviews
  • How reviews compare between brands

Expert Testimony

We’ve developed considerable in-house expertise when it comes to vetting CBD brands. At the same time, we know enough to know that we don’t know everything, which is why we used outside sources to back up some of our research.

To select the best CBD oils on the market today, we consulted with veteran consumers, popular CBD reviewers, and medical doctors. In some cases, we also took what brands had to say about themselves into account.

Original Research

We primarily determined which brands were worth our time by relying on our own research. Having determined a few essential criteria that separate good CBD products from bad, we did original research, and later parsed out our results into the more detailed criteria we’ve listed with each brand we reviewed.

Website Experience

You can learn a lot about a CBD brand within the first three seconds of navigating to its website. These days, there’s no excuse for a website to take longer than three seconds to load.

  • Clutter – If a CBD website was cluttered, visually confusing, or looked like it had been designed in 2004, we moved on immediately.
  • Content – A few spelling or grammatical errors here or there are to be expected. CBD entrepreneurs usually aren’t professional writers, after all. If the content on a website was offensively bad, however, or if it contained blatant claims (CBD cures ALL cancer. ), we knew we weren’t dealing with a reputable company.
  • Mobile-Responsiveness – Wow, this website looks great! Now, load it on your mobile device.

If elements overlap, it’s hard to find the menu, or images are too big, that site that looked so beautiful on a desktop isn’t properly mobile-responsive. Considering the fact that nearly 54% of eCommerce sales are expected to be completed on mobile devices in 2022, mobile optimization is no longer optional.

Brand Responsiveness

We already talked about each brand’s customer support in our reviews. Brand responsiveness, however, is slightly more complex than simply how quickly a brand responds to emails.

  • How developed is this brand’s social media presence?
  • How easy is it to contact that brand?
  • Does this brand offer its email or just a contact form?

These are examples of the questions we asked to determine each brand’s overall responsiveness.

Transparency

CBD companies have learned that they have to provide test results and other detailed product information if they want to succeed. How easy they make it to find this information, however, is up to each brand.

We preferred companies that went out of their way to provide as much information as possible on their products and processes. We avoided companies that made you work to learn what you needed to learn about their products’ quality and reliability.

Value

Value is more complex than simply how much each mg of CBD in your tincture costs. If a brand offers a cheap product, for instance, but makes customer service and returns impossible, for instance, it doesn’t actually provide high value.

This was perhaps the most important factor we considered as we assembled the 10 best CBD oils in this list. By evaluating dozens of different variables, we did our best to select the best overall value companies.

What You Should Know About CBD in 2022

Even though you’re now familiar with the 10 best CBD oil companies on the market, there’s still so much to learn about this non-intoxicating cannabinoid and what it has to offer. In this guide, we’ll provide more information on what CBD does and how to use CBD for a wide range of purposes.

What is CBD?

CBD is short for cannabidiol and is the most abundant active compound found in hemp, while THC is the most in marijuana.

CBD is just one of the 100+ cannabinoids found in hemp and marijuana. Other cannabinoids found in small amounts are Cannabigerol (CBG), Cannabinol (CBN), and Cannabichromene (CBC) to name a few that are similar to CBD but act on different receptors.

  • Isolated in 1940 but identified in 1963.
  • Safe and non-addictive substance.
  • It does not produce a “high” like Tetrahydrocannabinol (THC).
  • CBD can cause side effects such as dry mouth, diarrhea, reduced appetite, drowsiness, and fatigue.
  • CBD works by interacting with multiple receptors in our body that produces different effects.
  • CBD can interact with other medications when taken together since it gets broken down by the CYP450 enzyme that many prescription medications do.

How Does CBD Work?

According to a recent op-ed published in Cannabis Science and Technology, CBD may interact with your body in more than 20 distinct ways. However, scientists have recognized that the most important effects of CBD take place at two specific neuroreceptors.

For instance, researchers have closely researched the activity of CBD at the 5-HT1A receptor , which is the body’s most abundant serotonin receptor. Serotonin is responsible for dozens of critical bodily processes ranging from metabolism to mood regulation.

Scientists have also studied the effects of CBD at the TRPV1 receptor , which is involved in pain, inflammation, and epilepsy. CBD appears to exert the majority of its effects via these two biochemical interactions.

Does CBD Get You High?

CBD does not stimulate the CB1 receptor, which is the component of the endocannabinoid system that causes THC to make you feel high. Instead, CBD acts as an inverse agonist at this receptor, making it harder for your CB1 receptors to bind with THC.

As a result, CBD does not make you feel high. On the contrary, this cannabinoid usually produces a mild, non-intoxicating sense of relaxation.

Does CBD Have Side Effects?

The latest research on this subject , dating to 2019, indicates that CBD does not have any significant side effects. This cannabinoid is also remarkably non-toxic.

A few years ago, reports circulated that CBD causes liver damage. The study responsible for these reports was proven faulty, and its results have never been replicated.

Benefits of CBD

Scientists have researched the potential benefits of CBD for a wide range of diseases and conditions. Here are some examples:

Research into CBD for pain & inflammation

Both the 5-HT1A and TRPV1 receptors are involved in the sensation of pain. This year, researchers published a new study regarding the potential analgesic and anti-inflammatory properties of CBD, and efforts are ongoing to determine the exact analgesic potential of this non-intoxicating cannabinoid.

Research into CBD for depression & anxiety

Both depression and anxiety are largely modulated by the 5-HT1A receptor. In 2015, researchers took a deep dive into the potential antidepressant and anxiolytic properties of CBD, and research into this potential application of CBD is ongoing.

Research into CBD for sleep

Scientists are curious if the benefits of CBD may help you get to sleep at night. In 2019, for instance, a clinical study was conducted to determine the potential connection between CBD, anxiety, and sleep.

Research into CBD for cardiovascular health

Most types of cardiovascular disease are caused by either oxidative stress or inflammation. As a result, scientists have looked into the potential connections between CBD and cardiovascular health . While inconclusive at present, research into the potential cardiovascular benefits of CBD is ongoing.

Types of CBD Products

There are a few different ways to take CBD, and each ingestion method affects your body differently. Familiarize yourself with the four most common ways to use CBD:

Orally ingested CBD

CBD products that you chew up or swallow are considered orally ingested. Examples of orally ingested CBD products include capsules and gummies. While these CBD products are convenient and offer long-lasting effects, they have reasonably low bioavailability.

Sublingually ingested CBD

Because you hold CBD tinctures under your tongue before swallowing, these CBD products are considered sublingually ingested. Like orally ingested CBD, CBD tinctures end up in your digestive tract, but they have a chance to absorb through the thin membrane under your tongue before they enter your gut.

Topically applied CBD

Any CBD product you put on your skin is a topically applied CBD product. Types of topically applied CBD oil products include salves, lotions, and creams, and these products provide benefits in the area where they are applied.

Inhaled CBD

CBD flower and CBD vape cartridges are examples of inhaled CBD oil products. These products offer fast-acting, intense effects, but their benefits don’t last as long. Additionally, you should always exercise caution when allowing substances into your lungs.

How Much CBD Should I Take?

At present, there are no official guidelines regarding how much CBD you should take. Since this cannabinoid is non-toxic, non-intoxicating, and non-addictive, however, feel free to experiment as you determine which CBD dose is right for you.

As a general rule, you should start with a small CBD dose and increase the amount you consume as needed. Keep in mind that, since orally ingested CBD has low bioavailability, you might want to ingest more CBD per session if you use CBD capsules or edibles.

A good CBD dose to start with is 10mg to 20mg for the first 3 to 5 days to test your tolerance levels.

If you don’t feel noticeable effects from that dosage, increase your dose by 5mg to 10mg of CBD every 2 to 3 days to find your optimal dosage.

You may also start with higher doses, which is fine, but it’s essential to know that you may not notice the same effects after a couple of days or sometime after taking high doses. That’s just because you built a tolerance for CBD, and you should take a 3-5 day break from taking any CBD to reset your tolerance levels.

CBD FAQ for 2022 & Beyond

Let’s wrap up with some answers to common CBD questions:

1. Full Spectrum, Broad Spectrum, or CBD Isolate?

What is Full Spectrum CBD Oil?

Full Spectrum is a term used to describe a CBD hemp extract that contains a combination of cannabinoids, terpenes, flavonoids, and other plant oils that are extracted out of hemp. A key feature of Full Spectrum extracts, other than that it contains other compounds than just CBD, holds up to 0.3% THC per gram (1,000mg) of extract.

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What is Broad Spectrum CBD Oil?

A Broad Spectrum extract is very similar to Full Spectrum, except they separate the THC using a chromatography system making it THC-Free. This type of product will show no detectable THC levels, and it’s so low that even at very high doses, it won’t cause any psychoactive effects.

What is CBD Isolate?

CBD Isolate is a white crystalline powder form of CBD that is usually 99.8% to 99.9% pure CBD. This type of CBD extract doesn’t contain any other cannabinoids, terpenes, or plant compounds. The purity might look appealing, but without other plant compounds, it can’t produce the Entourage Effect’s synergistic effect, so we recommend Full Spectrum or Broad Spectrum.

2. Which Type of CBD Extract is Best?

Without a doubt, buy Full Spectrum or Broad Spectrum CBD products. Why? These extracts contain other beneficial compounds like those mentioned above that synergically work together to interact with even more receptors than CBD can, producing an “entourage effect.”

3. What is the Entourage Effect?

Entourage Effect, or Whole Plant Extract, is the term used to describe multiple plant compounds working together synergistically. This synergistic effect increases multiple receptor channels’ activity to enhance the benefits of cannabis or CBD oil.

4. Why are terpenes in CBD important?

Terpenes are compounds found in many plants, including hemp. They are created to provide an aroma for plants and to protect plants from threats such as microorganisms, pathogens, predators, and herbivores, to name a few.

Terpenes go back to 1998 when Professors Raphael Mechoulam and Shimon Ben-Shabat found that the endocannabinoid system demonstrated an “ entourage effect ” when they noticed the activity of receptors had noticeably increased versus an isolated cannabinoid.

Besides that, terpenes have a wide range of benefits such as analgesic and/or anti-inflammatory, mood-enhancing, and modulating CBD effects by producing synergy with cannabinoids.

Here are four terpenes we touched upon above:

  • Beta-Caryophyllene – Beta-caryophyllene is one of the only terpenes that acts as a cannabinoid. It stimulates the nervous system’s CB2 receptors , which modulate inflammation. Unlike CB1 receptors, CB2 receptors do not cause intoxication. However, these neuroreceptors have dozens of potential beneficial effects aside from their observed impact on inflammation.
  • Humulene – Like most terpenes, humulene has been studied for its potential antioxidant and anti-inflammatory effects. Humulene is also one of a few terpenes that have been researched for their potential antimicrobial benefits .
  • Linalool – Along with humulene, linalool has been studied for its potential antimicrobial and antioxidant benefits . This terpene is found in lavender as well as hemp.
  • Bisabolol – A rare terpene, bisabolol, has been studied for its potential ability to reduce skin inflammation , and the antimicrobial potential of this terpene has also been researched.

There are noticeable differences in effects between CBD products with extracts containing terpenes versus CBD products without terpenes. Colorado Botanicals was the only company that showed a terpene profile test from a third-party lab while the other companies didn’t.

5. Why is CO2 extraction better for CBD?

Many hemp extraction processes leave residual solvents behind that can be passed along to the purified extract. CO2, however, is a harmless natural substance, so CO2 extraction doesn’t result in residual solvent contamination.

6. Does CBD Oil Show Up on a Drug Test?

Although the chances are low, yes, CBD oil can show up on a drug test if you use Full Spectrum CBD oil every single day or often. The reason why is because CBD oil can contain up to 0.3% THC.

If you’re worried about THC showing up on a drug test from taking CBD oil, you should purchase Broad Spectrum CBD oils as they are THC-Free. Colorado Botanicals, which earned our #1 spot for the best CBD company of 2022, manufactures Broad Spectrum CBD oil, which we believe is probably one of the best we’ve come across.

7. What part of the hemp plant does CBD come from?

CBD, or generally all cannabinoids, terpenes, and flavonoids, are found in the buds, flowers, and leaves of hemp plants but are usually most concentrated in the flowers.

8. Is hemp seed oil the same thing as CBD oil?

No, hemp oil is not the same as CBD oil and if you’re looking to purchase CBD oil and come across “hemp oil” online, on Amazon, or in a store, then make sure to read the label.

If you read the label and don’t see any acknowledgment of “Cannabidiol” or “CBD,” then it’s not CBD oil.

Although CBD oil is technically hemp oil, it’s mainly used to define hemp seed oil, which is entirely different from CBD oil even though they are from the same plant.

Hemp seed oil is from hemp seeds where they are cold-pressed for oil production, which is used in cooking, beauty products, or a nutritional supplement as it contains nutrients, fatty acids, and protein.

On the other hand, CBD oil is extracted from the flower and buds of hemp, usually using CO2 or Ethanol to pull out the beneficial compounds found in CBD products.

This oil includes CBD, minor traces of other cannabinoids such as CBG and CBN, along with terpenes and flavonoids.

9. Why is MCT oil sometimes used in CBD oil?

  • CBD hemp extract at room temperature crystallizes, which is a natural chemical process, so mixing it with a fatty oil, such as MCT oil, it keeps the hemp extract in liquid form.
  • You might come across other CBD tinctures with hemp seed oil or olive oil as the substitute oil, and it’s for this specific reason.
  • Evenly distributes the CBD hemp extract oil in a tincture by using MCT oil, allowing a consumer to simply fill the dropper to their desired CBD dosage.
  • MCT oil is tasteless.
  • MCT oil is a rich source of fatty acids that has health benefits.

10. Can CBD oil be USDA-certified organic?

Many brands cultivate organic hemp without seeking certification. However, according to leading hemp legal scholars , it is technically possible to achieve USDA-certified organic status for CBD products.

11. Can CBD Oil Expire?

Yes, CBD oil does expire and usually lasts for 12 to 18 months until it goes bad. Purchasing quality CBD products from reputable CBD brands, like the best CBD companies recommended above, is critical to avoiding products that degrade in quality sooner than they should.

Best CBD Oil for Pain Relief & Inflammation: Highest Quality Brands On The Market

Over the past three years, CBD oil has become increasingly popular as a health and wellness supplement.

One of the main reasons people are interested in trying CBD oil is because of its pain-killing benefits. We’ll get into the details of how CBD is suggested to help with pain later, along with some suggestions for the best CBD oils for pain and inflammation.

The ability for CBD to help with pain is a significant advantage over conventional pain management options — which often involve addictive and potentially harmful medications. Instead, this natural supplement has very few side effects and an exceptional safety profile — all without compromising on effectiveness.

But how do you choose the right CBD oil for the job?

This is an important question to ask because the truth of the matter is that not all CBD oils work. Many simply contain too little CBD to be of any help, while others contain harmful contaminants like heavy metals, pesticides, or chemical solvents — all of which could add to the pain you’re already experiencing by damaging the sensitive nerve cells around the body.

We’re going to cover all of this in the article below. You’ll learn how to spot a high-quality CBD oil and how current evidence shows CBD to work inside the body.

This is a big topic, so let’s get started with our list of top-rated CBD oils for pain.

Top 10 Best CBD Oil Brands for Pain Management in 2022

Not sure which CBD oil to buy to help with chronic pain? Before we get into the nitty-gritty of how CBD is suggested to work for pain and inflammation, here’s our top 5 list of CBD oils I’ve used myself for back pain.

We’ll also offer some advice on a few ways you can spot a trustworthy CBD vendor even if they didn’t quite make it onto our list.

I’ve been using CBD for over 5 years now and I’ve stumbled upon some stellar companies with top-notch oils and fly-by-night businesses with oils that can’t simply don’t work.

I have a relatively short list of CBD brands that I fully trust and I want to share my choices with you so you can avoid some of the headaches and disappointment I’ve already endured.

Here are my top 10 CBD oil brands for pain:

1. Royal CBD (Best CBD Oil On The Market)

Technical Details
Total CBD Content 250 – 2500 mg
Available Flavors Natural, Mint, Vanilla, Berry
Potency 8.3 – 83.3 mg/mL

Get 15% off all Royal CBD products. Use code “CFAH” at checkout.

Why Royal CBD is My Top Pick:

As skeptical as I am towards the majority of new CBD brands, I decided to give Royal CBD a try because I liked the company’s dedication to quality. I love seeing companies that take what they do seriously.

You can tell right away from the color, flavor, and consistency of the oil that you’re dealing with a product well above average.

This oil is cheaper than most of the other premium CBD oils I’ve tried, comes in a full range of potencies, and uses some of the best full-spectrum hemp extracts I’ve ever seen. I’ve heard friends using this brand for quite some time and decided to give it a try for myself — so I ordered a few bottles in different strengths.

After taking the Royal CBD’s 2500mg full-spectrum CBD oil for just over a week, I noticed an improvement in my back pain. There was a time when I had serious problems falling asleep because of the sharp pains in my back that seemed to intensify whenever I laid down to fall asleep. It was a nightmare. I’d lay awake for hours changing positions to try and find a spot that didn’t leave me writhing in discomfort.

With this oil, my experience went far beyond what I expected. Not only did it help ease the pain, but my overall quality of sleep improved. I mean, I didn’t sleep longer but I began to wake up rested and with a clear head.

My favorite combination for this particular oil is the vanilla in the 1000 mg bottle. This is the largest potency option currently offered by Royal CBD and has the best value overall. I took the oil twice per day, once in the morning when I woke up, and again in the evening before bed. One bottle of the 1000 mg CBD oil lasted me about a month.

  • Sourced from US-grown organic hemp
  • Extracted with supercritical CO2
  • Contains the full spectrum of cannabinoids and terpenes
  • Available in 4 different strengths
  • Up to 2500mg of CBD per bottle
  • Lab-tested for potency and purity
  • Great natural flavors (no aftertaste and comes in multiple flavor options)
  • Free shipping within the USA
  • Newer brand on the market that only sells online, no physical presence

2. Gold Bee (Best Organic CBD Oil)

  • Premium Colorado-grown hemp
  • CO2 extraction
  • Contains full-spectrum CBD
  • Delicious kiwi flavor
  • Sweetened with organic honey
  • Lab-tested for potency and purity
  • Only one flavored option available
  • No high-strength oils (yet)

What I Like About Gold Bee:

I honestly believe Gold Bee makes the best organic CBD products out there. The brand combines premium Colorado-grown hemp with organic honey sourced from the Brazillian Rainforest. While Gold Bee offers a modest selection of oils — with up to 1200 mg of CBD per bottle — the formula is spot-on when it comes to the quality of ingredients. I’m totally not going to complain about the potency, as my back pain and sleep quality got better than with some high-strength oils I’ve tried in the past. Considering the quality of these products, they actually come at a bargain price. If you want to try other formats from Gold Bee, you can choose between its high-strength capsules and CBD-infused honey.

3. CBDPure (Runner Up)

Technical Details
Total CBD Content 100 – 600 mg
Available Flavors None
Potency 1.6 – 10 mg/mL
What I Like About CBDPure CBD Oil:

I love how transparent this company is. If I were judging companies solely by their transparency level, CBDPure would have scored the second place, right after Royal CBD. The company provides all the details about each stage of production when making this CBD oil. You can find all the third-party lab test results for each batch on the product page — something we’ve come to expect from any high-quality CBD company.

What really makes this company stand out is its incredible satisfaction guarantee. If you order the product and decide it wasn’t working for you, simply send it back and get a full refund. This satisfaction guarantee extends over 3 whole months — which is about three times longer than the industry average.

I keep a bottle or two of CBDPure oil in my medicine cabinet for achy moments after a run or hike with the kids.

The only real downside to this oil is the potency — which comes in denominations of 1.5, 5, and 10 mg/mL. This is suitable for more minor symptoms, but may not be enough for people with heavy CBD demands.

  • Sourced from Colorado-grown organic hemp
  • Extracted with supercritical CO2
  • Tested for the cannabinoid content and purity in a third-party lab
  • Rock-solid 90-day return policy
  • Narrow product range
  • Low potency
  • They don’t ship to every state (i.e. Louisiana, Indiana, Arkansas, Kansas)

4. HempBombs

Technical Details
Total CBD Content 300 – 4000 mg
Available Flavors Unflavored, Acai Berry, Orange Creamsicle, Peppermint, Watermelon
Potency 10 – 133.3 mg/mL
What I Like About HempBombs:

I used HempBombs CBD isolate-based hemp oil for quite some time before switching to full-spectrum CBD oil and in my opinion, this is the best brand when it comes to CBD isolates. Their products contain 99% pure CBD and ZERO THC.

Now don’t get me wrong, CBD isolates are great, they offer consistent doses of CBD, contain 0% THC, and are generally cheaper than their full-spectrum counterparts. In most cases, I like using a full-spectrum extract like Royal CBD oil because of something called the entourage effect — which is a concept highlighting the phenomenon where cannabinoids like CBD tend to work better when other hemp-derived compounds are also present.

In isolates, the only cannabinoid present is CBD.

HempBombs CBD oil is available in five different strengths — from 300mg to 4000mg per bottle. The CBD is added in the form of a 99% pure isolate — which means there’s going to be virtually no traceable amounts of any other cannabinoids, including THC, CBC, CBG, or CBN.

You can also buy these oils in different flavors. Hemp Bombs often adds new flavors to the list, but my all-time personal favorite is the Acai berry. It’s not too sweet but adds a really pleasant flavor to the otherwise bland CBD and MCT oil formula.

  • Sourced from 100% certified organic hemp from European farms
  • Extracted with supercritical CO2
  • Completely THC-free
  • Tested in third-party laboratories for purity and potency
  • Available in 5 separate strengths
  • Up to 4000mg of CBD per bottle
  • Lacks the synergistic effects from other cannabinoids
  • The highest potencies are overkill for most users
  • Uses synthetic flavoring agents

5. CBDistillery

Technical Details
Total CBD Content 250 – 5000 mg
Available Flavors None
Potency 8.3 – 166 mg/mL
What I Like About CBDistillery:

CBDistillery is now one of the largest CBD companies in North America. The company began in 2016 as a legacy brand for Balanced Health Botanicals.

Over the years, CBDistillery has had the chance to really dial-in its CBD oil formula. The company now sells its CBD oil in two formats — “full-spectrum” and “THC-free.” The THC-free option is great for people who want to benefit from the synergy of CBD and other cannabinoids but without bringing any THC whatsoever into their system.

Even the full-spectrum option contains less than 0.3% THC — which is well below the amount needed to cause any psychoactive effects. These oils are both completely non-psychoactive.

You can choose between five different strengths, starting at 250mg up to 5000mg of CBD per bottle. This covers just about every range of potencies you would ever need. We recommend opting for the higher potency options because they have the best value overall. The higher potency you purchase, the further your dollar gets you.

The more potent options also las the longest because you need smaller amounts of the oil each time to get the desired dose of CBD.

I tried the 1000mg bottle to keep myself calm during the first few months after giving birth to my first son and I must admit it helped me maintain my sanity during that time. I found it to have a remarkable calming effect on the body and mind.

  • Available as full-spectrum CBD or pure CBD oil (THC-free)
  • 5 strengths to choose from
  • Carries up to 33.3 mg of CBD per mL (in the 1000 mg bottle)
  • Excellent value CBD oil
  • The hemp isn’t certified organic
  • No flavor options available
  • The company website is clunky and hard to navigate

6. NuLeaf Naturals

Technical Details
Total CBD Content 240 – 4850 mg
Available Flavors None
Potency 48.5 mg/mL
What I Like About NuLeaf Naturals

Nuleaf Naturals is one of the most popular CBD companies in the United States — most likely related to how long the company has been in the business of selling CBD. Nuleaf naturals were one of the first CBD companies to enter the mainstream market.

Despite the companies longstanding reputation, Nuleaf Naturals only sells one CBD oil. When you go to the website you’ll find a few different options, including a pet oil — but it’s important to understand that these are all the exact same full-spectrum extract, the only difference is the bottle sizes.

We love the simplicity of Nuleaf Naturals product lineup. The oils come with a decent potency of around 48 mg/mL, and just about every bottle size you can imagine. This makes it easy for everybody to find a product that works for them regardless of the budget.

With that said, if you have the cash, we highly recommend getting the larger bottle sizes in order to get the best value for your money.

You can choose between five different sizes:

  • Sourced from organic Colorado-grown hemp
  • Extracted using supercritical CO2
  • Made from a full-spectrum hemp extract
  • More expensive than the other brands in this ranking
  • Narrow product range

7. Charlotte’s Web

Technical Details
Total CBD Content 200 – 1800 mg
Available Flavors Mint Chocolate, Lemon Twist, Orange Blossom, Olive Oil
Potency 7 – 60 mg/mL

About Charlotte’s Web:

Charlotte’s Web is one of the pioneers in the American CBD industry. Established by the Stanley Brothers, the company has coined a reputation of a trustworthy manufacturer by helping now late Charlotte Figi with her treatment-resistant epilepsy. Although the company has recently received a warning letter from the FDA due to their health claims, they still have many faithful customers and a massive number of positive reviews on the web.

Charlotte’s Web CBD oil comes in several potencies: 200 mg, 500 mg, 1500 mg, and 1800 mg of CBD per bottle. The highest strength offers 60 mg of full-spectrum CBD per milliliter. There are two bottle sizes to choose from: 30 mL and 100 mL; Charlotte’s Web also has flavored variants of its CBD oil, including Lemon Twist, Orange Blossom, Mint Chocolate, and Olive Oil.

What could the company do better?

First off, they could change their extraction method because they use ethanol, which is less efficient than CO2 extraction. Secondly, and most importantly, the suspension in olive oil makes them taste a bit bitter — even in the flavored versions.

Pros:

  • One of the most reputable brands on the market
  • Full-spectrum CBD
  • Delicious flavored versions
  • Up to 1800 mg of CBD per bottle
  • Available in two sizes: 30 mL and 100 mL
  • Third-party tested for potency and purity

Cons:

  • Non-organic hemp
  • Ethanol extraction
  • Suspension in olive oil (bitter taste)
  • The company received a warning letter from the FDA in the past due to inappropriate health claims

8. cbdMD

Technical Details
Total CBD Content 300 – 7500 mg
Available Flavors Natural, Berry, Orange, Mint
Potency 10 – 250 mg/mL

About cbdMD:

cbdMD is another popular manufacturer that offers a wide range of CBD extracts, from tinctures to gummies to capsules, bath bombs, topicals, sleep aids, and pet products.

The brand offers a wide range of pure CBD oils, with up to 7500 mg of CBD per bottle. The highest potency comes with a whopping dose of 200 mg of pure CBD suspended in MCT oil for higher bioavailability and a smoother flavor. cbdMD also has three flavored CBD oils: Berry, Orange, and Mint.

Despite an impressive potency range, cbdMD uses broad-spectrum CBD in their products, which doesn’t evoke the full entourage effect. The higher potency may not necessarily mean better results in this case.

The company has high transparency standards; not only does cbdMD broadly describe their activity from farming to testing, but they also provide batch-specific certificates of analysis for their products, including the results for potency and common contaminants like pesticides, heavy metals, and residual solvents.

Pros:

  • US-grown, non-GMO hemp
  • CO2 extraction
  • THC-free
  • Up to 7500 mg of CBD per bottle
  • Batch-specific certificates of analysis

Cons:

  • Limited entourage effect due to the lack of THC
  • Most people don’t need such high doses of CBD in their routine

9. Medterra

Technical Details
Total CBD Content 500 – 3000 mg
Available Flavors Natural, Citrus, Mint Chocolate
Potency 16 – 100 mg/mL

About Medterra:

Medterra is a small craft company from California. The brand offers premium CBD oils in different spectra: full-spectrum CBD, broad-spectrum CBD, and isolates. The potency of these products ranges between 500 mg and 3000 mg of CBD per bottle, which is a standard range. On top of the unflavored version, there are two flavored options: Citrus and Chocolate

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Medterra prides itself on making the real full-spectrum CBD because each bottle of its full-spectrum CBD oil comes with 2 mg of THC. However, these products are only legal in the states that have legalized higher amounts of THC for recreational use. So, if you want to buy the company’s products in all 50 states, your options are limited to broad-spectrum CBD and CBD isolate. These provide more CBD per bottle — upwards of 1000 mg.

The entire Medterra’s product range is tested in a third-party laboratory for their CBD content and safety.

Pros:

  • Premium-grade CBD oils
  • Up to 3000 mg of CBD per bottle
  • Available as full-spectrum CBD, broad-spectrum CBD, and isolates
  • Lab tested for potency and purity

Cons:

  • The “real” full-spectrum CBD oil isn’t available in all states
  • Some of the lab reports indicate higher CBD levels than stated on the bottle
  • No discounts for returning customers

10. Joy Organics

Technical Details
Total CBD Content 450 – 900 mg
Available Flavors Tranquil Mint, Fresh Lime, Summer Lemon
Potency 15 – 30 mg/mL

About Joy Organics:

Joy Organics holds the reputation of one of the most reputable CBD vendors in the industry. The company was established by a woman named Joy Smith, who has been using CBD oil to manage her problems with pain and sleep. After experiencing the benefits of CBD first-hand, she has decided to share her passion for cannabis with other health-conscious consumers.

The brand sells a range of broad-spectrum CBD products from certified organic hemp. They have many positive reviews all over the Internet; they also haven’t received any warning letter regarding health claims from the FDA — unlike many companies in this space (even the veterans like Charlotte’s Web).

The Joy Organics CBD oil features a broad-spectrum CBD formula in a modest potency range, from 450 to 900 mg of CBD per bottle. You can choose from three refreshing flavors: Summer Lemon, Fresh Lime, and Tranquil Mint. The strongest version of the Joy Organics CBD oil contains 30 mg of broad-spectrum CBD in every milliliter, which is a standard dose for most people who take CBD oil for daily supplementation.

In 2018, one of the company’s flavored CBD oils was found to contain a fungicide that is commonly sprayed on citrus fruit during independent lab testing. Fortunately, Joy Organics recalled the product shortly after this incident and implemented a new third-party testing system to make sure there are no flaws in the end product.

Pros:

  • Non-GMO, US-grown hemp
  • Supercritical CO2 extraction
  • Broad-spectrum CBD
  • THC-free
  • Delicious flavors

Cons:

  • A bit expensive
  • No high-strength oils

CBD Oil for Pain Management: Complete Guide for Beginners

Now that we’ve covered a few CBD oil options that are going to provide the best value for your money, let’s discuss how CBD is suggested to support chronic pain in the first place. We’ll also cover some of the most common ways people are using CBD oil for pain.

What is CBD Oil?

CBD stands for cannabidiol _ it’s one of the primary active ingredients in the cannabis plant. It’s completely non-psychoactive and offers a wide range of benefits to the human body.

CBD oil is a combination of a CBD extract, with a carrier oil to help dissolve and store the CBD. Most CBD oils use carrier oils like MCT oil, or hemp seed oil — which is then combined with CBD isolate, or full-spectrum hemp extract rich in CBD and other similar cannabinoids.

Cannabinoids like CBD are fat-soluble — which means they dissolve when mixed with oil, but won’t dissolve in water. By dissolving these compounds in an oil solution, the CBD becomes much easier to store and use. Instead of measuring out micrograms of CBD crystals or hemp resin, all you need to do is measure oil to get your dose of CBD. This can be done using a simple dropper that comes standard with most CBD oils.

Because of their ease of use, and long shelf-life, CBD oils have become the go-to method of using CBD and other hemp extracts.

You can also opt-out to use CBD-infused gummies if you wanted something discreetly, read our in-depth review on CBD Gummies to understand better.

How Does CBD Work?

Cannabis has been used for managing pain and inflammation for thousands of years.

The earliest records of the medical use of the herb date back to ancient China when the emperor Shen-Nung placed it among other therapeutic substances in the Chinese pharmacopeia (1). The leaves were wrapped around an injury as a poultice to reduce pain and discomfort, and reverse swelling and bruising.

Despite being a known medicine for a long time, scientists have only recently begun to unlock the mechanisms cannabis uses to achieve its important pain-killing benefits.

Since the discovery of the endocannabinoid system in 1992, CBD and other phytocannabinoids have been in the spotlight of modern medicine.

The endocannabinoid system is one of the most important neurochemical networks in the human body (2). It works by interacting with the endocannabinoid system — a series of hormones and receptors that help regulate over a dozen core processes in the human body. The active compounds in the cannabis plant are very similar to the naturally-produced hormones involved with our endocannabinoid system.

By interacting with the endocannabinoid system, CBD and other cannabinoids are able to modulate several key processes, such as:

  • Appetite
  • Immune function
  • Memory
  • Mood
  • Stress
  • Sensory perception (including pain)
  • Inflammation
  • Reproductive health
  • Nerve function
  • Sleep

How Can CBD Reduce Pain Transmission?

How does all of this relate to pain? The answer lies in the way pain is transmitted to the brain.

When we injure ourselves, cells in the immediate vicinity begin releasing compounds that trigger a cascade of inflammation and sensory activation — which is what triggers the pain transmission.

The pain signal is then sent to the spinal cord through a network of nerves distributed all around the body.

Once in the spine, the pain signal is sent through a gateway (opioid and vanilloid receptors) designed to limit the amount of signal that ends up in the brain for processing. This works like a border crossing. The border security decides whether or not you’re allowed to enter and what you can take with you.

In the context of pain, these gateways can limit the amount of pain signal that continues across the border to the brain. If more pain signal is allowed to pass, the brain perceives more pain. If the pain is stopped at the border, the brain perceives less pain.

Conventional pain medications work by activating the opioid receptors acting as a key gateway for pain transmission to the brain.

CBD has a similar effect, but through a different receptor is known as the vanilloid receptors. These vanilloid receptors are tasked with regulating a specific form of pain caused by either heat or inflammation. CBD has been reported to modulate this vanilloid receptor — leading to a reduction in the pain signals sent to the brain from inflammatory causes such as arthritis, muscle damage, or infection, to name a few.

CBD has other ways it can limit pain transmission as well:

  • CBD may reduce inflammation, limiting the initial cause of pain in the body
  • CBD acts as an antioxidant, helping the body resist and recover from damage
  • CBD relaxes muscle fibers, reducing pain caused by muscle spasms and tightness

More research is needed to fully understand how CBD and other active cannabinoids can block pain. Every year dozens of new research papers are published in an attempt to paint a clear picture of how CBD works, how to get the most benefit from the supplement, and what its limitations are.

(Pain Transmission Pathway to the Brain)

Choosing CBD Oil Companies: How to Differentiate the Good From the Bad

CBD has become a lucrative business. Companies are selling a myriad of different CBD oils and other products in an attempt to cash in on the new health trend. This means there are a lot of excellent products coming to market, but it also means there’s a lot of trash as well. It’s important as a CBD user that you understand what makes a CBD oil good, and what makes it bad so you can avoid wasting your money, or worse — using CBD oils that contain harmful or damaging ingredients.

Let’s cover the most important points to remember when shopping for CBD oil online or in-store.

1. Check the Hemp Source

The source of the hemp used to make the oil is vitally important when it comes to determining which CBD oils are the best. The main reason comes down to the botany of the hemp plant itself.

Hemp is a bio-accumulator — which means it has the tendency to absorb compounds from the soil and accumulate them in its leaves, stems, and roots. The deep taproots of the hemp plant stretch far beneath the soil, pulling out and storing all the heavy metals and other elements it can find in the soil.

This aspect is in part why hemp is so nutritious, but it also means that plants grown in contaminated soils often contain contaminants that can be harmful to your health. Some of the worst offenders are heavy metals — which can build up in the body over time and lead to severe long-term health effects.

You want to avoid consuming heavy metals at all costs.

Poorly grown hemp could contain heavy metals, as well as other contaminants like mycotoxins, or pesticide residues that will end up in the CBD oil after all the processing is complete.

For this reason, it’s important to purchase CBD oil from companies that account for this effect. Only buy from company’s that make an effort to source hemp from organic farms, and take measures to assess every batch of hemp that enters the facility to determine heavy metal, microbial contaminant, and pesticide contamination.

The best hemp sources tend to come from states like Oregon, Colorado, or Alabama, as well as neighboring countries like Canada or Scandinavian countries. These places are all known for having high standards for hemp cultivation, and clean soils.

2. Look for CO2 Extracted Products

Once the company has the hemp, they need to extract the CBD from it. You can do this in many different ways using solvents like ethanol, methanol, hexane, ether, or butane. All of these solvents work to strip the active compounds from the hemp plant and can then be evaporated to leave behind a pure CBD-rich resin.

however, there’s a problem with these solvents.

Even in professional lab settings, it can be very difficult to remove all traces of these solvents from the final product. Most of these solvents are toxic to the human body, even in trace amounts.

Therefore, the best companies are using another method to strop the active ingredients from the starting hemp material. This method uses CO2 placed under high pressure. the high pressure and temperature control convert the CO2 into a phase that’s neither liquid nor gas. This special state is referred to as being supercritical.

Supercritical CO2 acts just like any other solvent, but with one key benefit — as soon as the pressure is relieved, the gas evaporates completely, leaving behind no harmful chemical residues.

when shopping for CBD oil, it’s ideal to look for a company that uses supercritical CO2 to extract the CBD rather than the toxic solvents mentioned above. Supercritical CO2 is very expensive and highly technical — but usually produces a far superior product in the end.

If a company is using harsh solvents like butane or propane (or they don’t tell you anything about their extraction methods), it’s a sign that you should look for another brand.

3. Ask for Third-Party Lab Reports

Every company has the option to send their products to an independent lab or third-party testing.

These laboratory tests check for the entire cannabinoid profile of the extract and are able to detect over 200 common contaminants.

Before a CBD product becomes available for sale, it should pass the laboratory test for potency and purity. If any inconsistencies are shown between different batches of the same product, the company should rework it and send it for analysis once again.

High-quality CBD companies will continually send each batch of product to a lab with no affiliation to the company (called a third-party or independent lab) for testing. These results are then published publicly on the website for customers to view.

The best companies will take this even one step further — adding a database and batch numbers on every bottle of CBD oil so you can view the results for your specific bottle of oil. Third-party testing is now an industry standard.

Always buy your CBD oil from companies that show third-party lab reports on their website. Only then will you know what’s inside the bottle before you even order a product. If the company is producing CBD oil that’s as high quality, as they say, there should be nothing to hide in these lab tests and they should be listed publicly on the company website. If you can’t find them on the site, you can ask customer service for these as well.

If these tests don’t exist, or you can’t track them down from the website or customer service — it’s best to avoid this company and move on to another that takes this important step seriously.

What the Research Says About Using CBD Oil for Pain:

Understanding how CBD works is no simple task. This compound is incredibly complex — working through a number of unrelated receptors around the body, interacting with enzymes, cell membranes, and various other cell structures. This makes studying CBD very difficult.

Nevertheless, there have been thousands of research papers published on medical marijuana — seeking to understand the interaction between cannabinoids like CBD and the human body. A lot of this research specifically focused on the effects of CBD on various forms and causes of pain. Let’s explore some of the results this research has yielded in the context of pain management.

1. CBD Oil for Chronic Back & Nerve Pain

The painkilling properties of cannabidiol have been most thoroughly studied in animal models, as well as a handful of human clinical trials.

One of the best studies we have available on the topic is a meta-analysis published in 2017. This analysis looked at 24 different clinical trials involving 1,334 patients over several years and demographics. These studies all used various forms of cannabis for treating chronic pain. The analysis reports that many of these studies showed a reduction in chronic pain scores by 50% or more (3) — suggesting the cannabis plant to be a potential treatment for chronic pain.

Another clinical trial looked at the effects of a combination of CBD to THC in the treatment of intractable cancer pain. This study found that twice as many people in the treatment group given CBD and THC had a 30% or more reduction in pain symptoms at the conclusion of the trial (6).

Even though more clinical trials on humans are needed to gauge how CBD affects specific forms of pain or other conditions, scientists believe the efficacy of CBD in treating chronic pain is related to its anti-inflammatory effects (3).

2. CBD Oil for Arthritis

CBD has had a lot of research as a potential alternative to prescription and non-prescription pain medications commonly used for alleviating arthritis pain.

Researchers have found a clear link between the endocannabinoid system and the pathophysiology of osteoarthritis, which is a degenerative joint disease associated with chronic pain and inflammation (4).

One of the key areas CBD is thought to support osteoarthritis specifically is through the effects on an enzyme known as 5-lipoxygenase — AKA 5-LOX. CBD has been shown to inhibit this enzyme (7), which converts fatty acids into pro-inflammatory compounds. These inflammatory messengers have been shown to be a key component in the underlying inflammation involved with osteoarthritis (8).

By reducing the underlying causes of arthritis pain, CBD is thought to reduce the overall burden of pain from the condition over the long term.

3. CBD and Multiple Sclerosis (MS) Pain

Due to its antioxidant and anti-inflammatory properties, CBD is a potent neuroprotective — which is how experts believe CBD is able to relieve debilitating MS pain, —which affects roughly 50–70% of patients diagnosed with the condition.

A study conducted on animals at Cajan Institute tested the anti-inflammatory effects of CBD on mice the researchers wanted to find out if CBD can provide a reversed inflammatory response on those cells. After ten days, the researchers found a reduction in inflammatory markers with a rodent encephalitis model designed to imitate the impact MS has on the body (5).

More research is needed to see exactly how these effects are translated to humans. Currently, there are 23 clinical trials currently underway, or planned within the next 12 months seeking to explore the effects of CBD on MS.

4. CBD Oil in Sports: Injuries & Muscle Endurance

Cannabidiol can be applied in two different ways when it comes to pain and physical activities. For example, when you administer CBD orally in the form of oil as a post-workout, it helps alleviate the muscle inflammation that troubles athletes once they go beyond the edge again.

If, however, you’re suffering from an injury, it’s best to apply CBD topically. Its anti-inflammatory and neuroprotective properties allow the cannabinoid to relieve pain and improve regeneration capacities.

Does CBD Have Any Side Effects?

The main reason why parents are so enthusiastic about CBD is that this cannabinoid is completely non-intoxicating, doesn’t cause addiction, and has only a few mild side effects when taken at excessive doses.

Research shows that even doses up to one and a half grams have no severe side effects on human health (9).

Despite being a notoriously safe supplement, there are some side effects of using CBD in high doses. Let’s cover the most common side effects people report from using CBD:

  • Anxiety
  • Brain fog
  • Reduced appetite
  • Mood changes
  • Diarrhea or constipation
  • Dizziness or lightheadedness
  • Drowsiness or fatigue
  • Dry mouth
  • Nausea and vomiting

The most common side effect by far, like other forms of cannabis, is dry mouth. This is best managed by taking your CBD oil along with some juice like pineapple or orange juice.

Another common side effect is lowered blood pressure, which may trigger another unwanted reaction — lightheadedness. This side effect is important to consider if you suffer from low blood pressure already or are taking blood pressure-lowering medications.

Always consult your doctor before using CBD or other cannabis extracts if you’re taking prescription medications or have underlying medical conditions.

In Summary: Buying CBD Oil For Pain

As CBD becomes more popular around the world, scientists are publishing new research on cannabinoids on a near-weekly basis. As time goes on, experts are mapping out the complicated mechanisms CBD and other hemp derivatives are using to support both acute and chronic pain of all different origins.

Here are the main takeaways from the current research:

  • CBD inhibits inflammation at several different levels
  • CBD offers antioxidant support
  • CBD may relieve muscle tension and inflammation
  • CBD interacts with the vanilloid receptors in the brain responsible for regulating inflammatory pain transmission

When it comes to pain, CBD appears to target the cause of the problem instead of just masking its symptoms.

Getting relief on so many levels and without any harmful side effects or risk of addiction is the reason why CBD oil has become so popular over the past half a decade.

I hope this guide has managed to clear up any confusion regarding CBD oil and pain, and given you the insight necessary to find the right CBD oil for the job.

Have you tried CBD oil for chronic pain? Did you feel any difference? Let me know in the comments below!

References:

  1. Brand, E. J., & Zhao, Z. (2017). Cannabis in Chinese Medicine: Are Some Traditional Indications Referenced in Ancient Literature Related to Cannabinoids?. Frontiers in pharmacology, 8, 108.
  2. Alger B. E. (2013). Getting high on the endocannabinoid system. Cerebrum: the Dana forum on brain science, 2013, 14.
  3. Aviram, J., Samuelly-Leichtag, G. (2017) Efficacy of Cannabis-Based Medicines for Pain Management: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Pain Physician, 20(6), E755-E796.
  4. Bruni, N., Della Pepa, C., Oliaro-Bosso, S., Pessione, E., Gastaldi, D., & Dosio, F. (2018). Cannabinoid Delivery Systems for Pain and Inflammation Treatment. Molecules (Basel, Switzerland), 23(10), 2478.
  5. Elliott, D. M., Singh, N., Nagarkatti, M., & Nagarkatti, P. S. (2018). Cannabidiol Attenuates Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis Through Induction of Myeloid-Derived Suppressor Cells. Frontiers in immunology, 9, 1782.
  6. Johnson, J. R., Burnell-Nugent, M., Lossignol, D., Ganae-Motan, E. D., Potts, R., & Fallon, M. T. (2010). Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC: CBD extract and THC extract in patients with intractable cancer-related pain. Journal of pain and symptom management, 39(2), 167-179.
  7. Takeda, S., Usami, N., Yamamoto, I., & Watanabe, K. (2009). Cannabidiol-2′, 6′-dimethyl ether, a cannabidiol derivative, is a highly potent and selective 15-lipoxygenase inhibitor. Drug Metabolism and Disposition.
  8. Lascelles, B. D. X., King, S., Roe, S., Marcellin‐Little, D. J., & Jones, S. (2009). Expression and activity of COX‐1 and 2 and 5‐LOX in joint tissues from dogs with naturally occurring coxofemoral joint osteoarthritis. Journal of orthopaedic research, 27(9), 1204-1208.Chicago
Nina Julia

Nina created CFAH.org following the birth of her second child. She was a science and math teacher for 6 years prior to becoming a parent — teaching in schools in White Plains, New York and later in Paterson, New Jersey.

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