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Hat is a common dosage for cbd oil

How to Dose CBD Oil Properly

With so many CBD oil brands on the market, it is often difficult to know which ones are the best, and more importantly, how much CBD you should take.

CBD-rich oil comes in various concentrations and forms, and while most bottles have a label with suggested dosing, CBD oil works differently for each person. If you’ve never tried CBD or you are still trying to figure out what works best, then this article is for you. However, you should always consult with your doctor before beginning any form of routine.

Continue reading as there are a few essential things to understand about CBD oil and CBD oil dosages.

What the Research Says About CBD Oil Dosing

Research suggests that compared with many other medications, CBD is generally safe and well-tolerated.

In clinical experiments, scientists use doses of CBD that range from 20mg per day to 1500 mg per day. Even at higher doses, serious side effects from CBD in these experiments have been extremely rare.

Research suggests that compared with many other medications, CBD is generally safe and well-tolerated.

One study investigated the effects of different doses of CBD (300, 600, and 900mg) on 38 healthy human volunteers. None of the volunteers showed any noticeable effects on mood or anxiety or significant changes in blood pressure for all doses. The volunteers that took 900mg CBD had a significantly decreased heart rate four hours following the consumption of CBD. However, the value didn’t go below the healthy human heart range.

In another study investigating the longer-term effects of CBD, schizophrenic patients took CBD for 28 days with doses beginning at 200mg and increasing to 800mg. Three patients decreased their doses back to 600mg per day because of unwanted side effects. However, none of the study participants demonstrated any notable safety concerns throughout the experiment.

What Does the Research Say about CBD Side Effects?

Some worries about CBD include the potential for dangerous effects on the liver, based on a 2019 experiment showing CBD caused liver toxicity in rats.

In this experiment, scientists used the equivalent of the maximum recommended human dose for EPIDOLEX® – a CBD prescription medication – suggesting safety concerns about the liver may only be relevant for higher doses. In line with this claim, one case study demonstrated that 300mg of CBD for ten days in a human subject had no effects on the liver.

Another safety concern about CBD is the potential for causing adverse effects on reproduction. The empirical evidence for this comes from animal studies that show CBD can affect hormones and fertility.

One human experiment demonstrated that both 300mg and 600mg of CBD did not affect reproductive hormones. However, this study did not investigate the long-term effects, so the impact of different CBD doses on reproduction is still unclear.

It’s important to note that CBD oil doses used in clinical studies may differ from CBD doses found in-store or online. Studies generally use CBD isolate, which often requires much more to get the same effects as broad or full-spectrum CBD.

Although CBD may be effective or be safe in a research study, individual differences (see below) and differences in the purity of products might mean the effects aren’t the same for you.

Important Things to Know About CBD Oil Dosing

CBD dosing is not a straightforward matter. There are several different factors to consider, ranging from genetics to what condition one is hoping to treat. Here’s what you need to know:

1) Every Person Is Different, and May Require a Different Dosage

If you’ve been reading the articles on our site, you are probably familiar with the endocannabinoid system. The endocannabinoid system is extremely complex and far from understood, but we do know that every person’s physiology is different. Therefore, while the instructions on a CBD oil bottle may be informative and clear, the standard dosing may affect two different people in entirely different ways.

2) Genetics, Tolerance, and General Health

Expectations of CBD’s effects may vary. For instance, some people want relief from severe, debilitating chronic pain conditions, and others are looking to help their day-to-day anxiety. However, everyone has unique genetics, tolerance, and general health.

3) It’s Not a Miracle Cure

It’s important to understand that CBD oil is not a miracle cure. Don’t expect to take a few drops and voilà; you’re cured.

The effects of CBD oil are not instant. CBD can take time to work, and results may not happen overnight. The key is finding the right administration route and dosage, as well as maintaining consistency.

How to Calculate CBD Oil Dosage

First, you need to determine the strength of your CBD oil. To do this, you need to use the formula:

Amount of CBD per bottle (mg per bottle) ÷ volume of bottle (ml) = concentration of CBD in bottle (mg/ml).

For example, if your bottle contains 600 mg and is a 30 ml bottle then the strength of the bottle will be 20 mg/ml:

600mg ÷ 30ml = 20 mg/ml

From here, you can work out the concentration of each drop using the formula:

Concentration of CBD in bottle (mg/ml) ÷ number of drops in 1 ml = amount of CBD in each drop

The number of drops in 1 ml is usually 20 (with each drop equivalent to 0.05 ml). However, you should be able to find this value on the label of your CBD tincture bottle.

Going back to the previous example, assuming the number of drops in 1 ml is 20, each drop will contain:

20 mg/ml ÷ 20 drops = 1 mg per drop

The final step is to multiply your desired dose by the concentration of each drop using the formula:

Desired dose (mg) ÷ concentration of each drop (mg/drop) = number of drops required for dose

Once you know how to figure out how much you’re taking, the rule is to start low and go slow. Typically, it’s recommended to start with a low amount, like 10mg, and then titrate up until the desired effect is achieved.

The exception is for those taking CBD for sleep, as studies indicated that under 60mg of CBD can be more stimulating and that it requires over 60mg of CBD to help with sleep.

Recommended Dosage of CBD Oil

There are some general guidelines relating to the recommended dosage of CBD oil for specific conditions. However, there is no one-size-fits-all answer to questions like, “what is the correct CBD dosage for pain?” The reason is simple, not everyone has the same physiology, body weight, and size, or will experience identical effects after using CBD.

Therefore, rather than looking at individual, anecdotal evidence, we’ll discuss what CBD doses were effective for participants in studies relating to pain, anxiety, and sleep disorders.

CBD Dosage for Pain

Because of the varied nature of pain, it’s difficult to recommend a CBD dosage for pain.

In one study, researchers investigated the effects of CBD for various pain-related conditions in 400 different patients. Doses in the experiment ranged all the way from 40mg per day to 300 mg per day.

The researchers found that CBD was generally helpful at reducing pain and improving the patients’ quality of life.

CBD Dosage for Anxiety

Most studies investigating CBD for anxiety have used CBD isolates, with doses ranging between 300-600 mg per day.

There is some evidence to suggest that cannabinoids may have a biphasic effect when it comes to treating anxiety. A biphasic effect is when different doses have opposite reactions. In the case of CBD and anxiety, this means that whereas low doses can help reduce anxiety, high doses may actually increase anxiety.

CBD Dosage for Sleep

In one study – the researchers provided participants with either anxiety, sleep disorders, or both, with 25 mg CBD per day for a month. This dose helped improve sleep quality in 70% of patients.

If you’re using CBD to help improve sleep, it’s recommended to take a dose in the evening at least an hour before bed to allow time for the effects to kick in.

The Standard CBD Oil Dosage Manual

Now, remember, this is a very general guide.

Furthermore, it is always best to consult with your doctor before starting a CBD regimen. With that said, there are a few common dosage strategies that might work for you:

  1. Start by taking one dropper of a low-dose CBD. Ensure you are in a calm and relaxed environment; it’s advised not to participate in any strenuous activity or operate machinery. It’s also important to see how you feel as everyone reacts differently.
  2. If all goes well, but you don’t see the desired effect, increase the amount to 2 droppers per day, spread throughout the day. For example, take one in the morning and one in the evening.
  3. If you don’t experience any change, then increase at a slow rate and see how you feel.
  4. If no effect occurs but side effects set in, it may be that a different route of administration (vape, topical, etc.) is needed. Or perhaps CBD may just not work for you.

CBD Oil Dosage Recap

If you are just starting out with CBD oil, remember to start small and consult with your doctor. Fortunately, there is no established lethal dose of CBD, according to ProjectCBD, a non-profit organization dedicated to making CBD research transparent.

As with any new health product, it’s essential to know how your body reacts to CBD.

However, one should still be cautious, and as with any new health product, it’s essential to know how your body reacts to CBD. Increase the dosage gradually, and if you feel that the CBD oil isn’t positively affecting you, you should consult with a medical professional.

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Once you’ve found the ideal dosage, make sure you’re using a good-quality oil. Take a look at some of the best CBD oils on the market below.

How many drops of CBD oil should I take?

You can determine how many drops of CBD oil you need to take using the formulas in our section ‘How to Calculate CBD Oil Dosage’ above.

Is it possible to take too much CBD?

Although there are no published case reports of lethal overdose from CBD to date, high doses of CBD can have unwanted side effects, such as sedation, headaches, and nausea. You can find out more about CBD side effects in this article.

Because CBD decreases blood pressure, taking CBD could cause complications relating to dangerously low blood pressure levels, such as fainting if you already have low blood pressure.

The potential interactions between CBD and certain prescription medications mean unwanted side effects may be more likely when CBD is combined with other drugs. You can learn more about CBD interactions in this article.

How many mg of CBD oil per day?

The amount of CBD oil people choose to take depends on several factors, such as the reason for use, body weight, and general health levels.

It’s always better to start with a low dose, such as 10 mg per day, and then gradually increase the dose to a level that best suits you.

What are 10 drops of 100mg CBD oil dosage?

The answer to this question will be dependent on the volume of your CBD tincture bottle and the number of drops per ml.

Standard bottles of CBD contain 30 ml, and each ml is usually the equivalent of 20 drops.

You can work out this calculation using the formulas written above.

Amount of CBD per bottle (mg per bottle) ÷ volume of bottle (ml) = concentration of CBD in bottle (mg/ml)

So the concentration of CBD in a 30ml bottle will be:

100mg ÷ 30ml = 3.3 mg/ml

You then need to work out the amount of CBD in each drop.

Concentration of CBD in bottle (mg/ml) ÷ number of drops in 1 ml = amount of CBD in each drop

So if there are 20 drops in 1 ml, the equation will be:

3.3mg/ml ÷ 20 drops = 0.17 mg per drop

Therefore 10 drops will be 10 multiplied by this value, which gives a dose of 1.7 mg of CBD.

How do I know what the correct dosage of CBD oil is for me?

It’s difficult to tell what the correct dose of CBD is for various reasons, but if you begin with a small dose, you can gradually increase the amount until you find the right dose that works best for you.

What Dosage of CBD Should You Take?

Kendra Cherry, MS, is an author and educational consultant focused on helping students learn about psychology.

Verywell Mind articles are reviewed by board-certified physicians and mental healthcare professionals. Medical Reviewers confirm the content is thorough and accurate, reflecting the latest evidence-based research. Content is reviewed before publication and upon substantial updates. Learn more.

John C. Umhau, MD, MPH, CPE is board-certified in addiction medicine and preventative medicine. He is the medical director at Alcohol Recovery Medicine. For over 20 years Dr. Umhau was a senior clinical investigator at the National Institute on Alcohol Abuse and Alcoholism of the National Institutes of Health (NIH).

Verywell / Madelyn Goodnight

CBD is available in a number of different formulations including creams, tablets, oils, and gummies. These can vary in terms of their ingredients as well as dosages, and there is not a great deal of research available on what dose might be beneficial or safe to treat certain conditions.

Cannabidiol (CBD) is the second most abundant cannabinoid found in marijuana. Unlike tetrahydrocannabinol (THC), CBD does not have psychoactive effects. Interest in the use of CBD for health purposes has grown tremendously in the last few years.

CBD is believed to have a range of positive physical and mental health effects. Because of this, it has become increasingly popular as a way to alleviate everything from anxiety to sleep disorders.

In order to determine if CBD is right for you, it is important to consider its potential benefits, side effects, and available research on safe dosages.

Possible Benefits

CBD is just one of hundreds of different compounds found in the cannabis plant. While cannabis has been used in holistic medicine for many years, only recently have researchers begun to explore some of the medicinal purposes for CBD and other cannabinoids.

While further research is still needed, there is some evidence that CBD may have some beneficial mental health effects. These include:

  • Alleviating depression: Some research also indicates that CBD may be useful as a treatment for depression. Studies suggest that the cannabinoid might have an influence on how the brain responds to serotonin, a neurotransmitter that plays a key role in mood. People with depression sometimes have a low level of serotonin, so CBD may help the brain use available serotonin more effectively.
  • Improving sleep: While the reasons are not entirely understood and require further research, CBD also appears to have potential as a treatment for sleep problems. For example, one study found that people who took CBD also reported improvements in the quality of their sleep.
  • Reducing anxiety: Anxiety is one of the most common types of mental health conditions, affecting almost 20% of American adults each year. Research suggests that CBD may help alleviate acute symptoms of a number of anxiety-related conditions including generalized anxiety disorder, obsessive-compulsive disorder, and social anxiety disorder.

In addition to the mental health benefits, CBD may also have therapeutic benefits for a range of other conditions. The World Health Organization suggests that CBD may have beneficial effects in the treatment of:

  • Alzheimer’s disease
  • Arthritis
  • Cardiovascular disease
  • Diabetes
  • Infection
  • Inflammation
  • Multiple sclerosis
  • Nausea
  • Pain
  • Psychosis

It is important to remember that these benefits have not yet been conclusively proven. More research is needed to determine the role that CBD might play in the treatment of different disorders and health conditions.

Research

There have been a number of studies that suggest that CBD may have a number of different physical and mental health uses. However, more research is still needed to better understand the substance’s potential applications and possible long-term side effects.

A 2019 comprehensive review published in The Lancet Psychiatry looked at previously published studies. The review ultimately concluded that there was little evidence to support the use of CBD for mental health purposes and suggested that more research is needed in order to substantiate its use to treat symptoms of conditions such as anxiety, depression, and insomnia.

It is important to remember that this doesn’t mean that CBD isn’t effective. Many of the studies that were included in the review were small, had few participants, and were not randomized controlled trials.

This suggests that more research involving more participants and well-designed studies is needed in order to better understand if, how, and why CBD works.

While its effectiveness is still up for debate, one 2017 review found that it was a relatively safe option.   While it is important to remember that there is still a great deal we don’t yet know about CBD and its effects, it is something that you might opt to try to see if you experience any benefits.

How Much Should You Take?

The dosages used in research studies vary and there is no consensus on how much should be used for specific conditions. If you do decide to try CBD, it is also important to note that there is no universally agreed upon dose. Research also suggests that people may respond differently to various dosages, so the amount that is right for your needs might vary.

CBD Dosages

Some dosages that have been used in research studies for different conditions include:

  • Anxiety: 300 to 600 mg
  • Bowel disease: 10 mg per day
  • Cancer-related pain: 50 to 600 mg per day
  • Parkinson’s disease: 75 to 300 mg per day
  • Poor sleep: 25 mg per day
  • Psychosis: 600 mg per day

One 2020 review of studies found that participants showed improvements in anxiety levels after single doses of CBD ranging from 300 to 600 mg.   Such results indicate that the CBD may hold promise as a treatment to alleviate symptoms of acute anxiety.

It is important to remember that you should always talk to your doctor before using CBD if you have symptoms of a serious mental or physical health condition. CBD could potentially worsen symptoms or interact with other medications you are taking.

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Looking at the dosage information for the CBD product that has been FDA approved can also be helpful. For Epidiolex, an FDA-approved cannabis-derived medication used to treat seizures in people with certain types of epilepsy, the starting dosage is 5 milligrams per kilogram of body weight. This dose can later be increased to 5 mg per kilogram of body weight twice a day.

Other CBD products are not FDA regulated and do not have officially recommended dosages. This can make it difficult to determine how much you might need, but there are some things you can consider that might help.

  • Assess your sensitivity to CBD: Your individual ability to tolerate CBD can also play a role in determining how much you need. If you are very sensitive to the effects of CBD, you should take a small dose. Some people may find that they are not as affected by the substance, so they may need to take a larger dose to notice any beneficial effects.
  • Consider individual factors: When you are trying to decide how much CBD to take, there are a number of factors you should consider. These include the formulation and concentration of the capsule, oil drops, or gummies you are taking, the symptoms you are treating, and your age, sex, weight, and overall health. Generally, people with heavier bodies need to take a little more to achieve the same effects. Men may need a larger dose, while older people may need less.
  • Consider the symptoms you’re treating: The symptoms you are trying to alleviate can also play a role in the CBD dosage you need to take to see results. In one study, participants who took 25mg of CBD each day had improved sleep quality, although the results were not consistent.   However, you might find that you need a lower or higher dose if you are treating another type of condition.
  • Try a dosage calculator: Researchers note that while the variety of dosing strategies and formulations make it difficult to determine efficacy, there are a number of online “dose-calculators” available online (such as mydosage.com) that are designed to help people choose the correct dose.   The accuracy of such calculators is difficult to assess, but it may be a good place to start.

Before you try CBD, discuss your plan with your doctor. They may be able to recommend a dose and help you better understand any potential risks, complications, side effects, or interactions you might experience.

Start With a Low Dose

Unless your doctor recommends a specific dose, start by taking 10 to 20 mg a day. Take this for a week to ensure that it is well-tolerated and that you don’t experience any unwanted effects or an allergic reaction.

If this dose does not have the desired effect, try increasing in increments of 5mg each week until the desired amount is reached.

In studies, amounts vary from as low as 20 milligrams per day to up to 1,500 milligrams (mg) per day. The World Health Organization reports that dosages in clinical research studies typically range between 100 and 800 milligrams per day.  

Is It Possible to Take Too Much?

So what is the maximum amount of CBD you should take? Researchers have found that 600 mg per day appears to be safe, but one study suggested that doses of up to 1,500 mg a day are safe and tolerated well.

However, it’s important to remember that research is still in its infancy and experts do not yet fully understand the potential long-term impacts of CBD usage. For that reason, you should always discuss your CBD use with your doctor.

Starting at a lower dose and working your way up to the amount you need may be the best ways to avoid taking too much.

How to Take CBD

The amount of CBD found in a product may depend on different factors, including the formulation and method of administration. CBD products are available in a number of different forms including oils, capsules, tablets, nasal sprays, and gummies.

One of the most popular ways to take CBD is as an oil. Such products are made by combining CBD with some type of carrier oil, such as coconut oil. Some more recently developed products include dietary supplements, foods, beverages, lotions, salves, and cosmetics.

The type of CBD product you choose may depend on what you are trying to treat. If you are looking for general mood improvements, a dietary supplement might be a good option.

If you are targeting specific symptoms of a condition, taking an oil, capsule, or gummy might be a better way to obtain a higher, more concentrated dose.

Topical applications may produce localized effects, but they are unlike to have any mental health benefits.

What Kind Should You Take?

It’s also important to remember that many products don’t contain just CBD on its own. There are three types of CBD available:

  • Isolate contains CBD and only CBD.
  • Broad-spectrum contains CBD and other cannabinoids, but not THC.
  • Full-spectrum contains CBD, THC, and other cannabinoids.

It may be helpful to take a broad-spectrum product since research suggests that CBD’s effects may be most beneficial when taken in conjunction with other cannabinoids, a phenomenon known as the entourage effect. CBD may also help mitigate some of the effects of THC.

Side Effects

While CBD is generally well-tolerated, this does not mean that you won’t experience any side effects.

Some of the most common side effects that people experience when taking CBD include:

  • Appetite changes
  • Diarrhea
  • Nausea
  • Dizziness
  • Stomach upset
  • Weight changes

Some recent research has generated concerns over the safety and potential long term effects of CBD. One study involved giving mice an equivalent of the maximum dose of the CBD medication Epidiolex, which is used to treat certain forms of epilepsy. The results indicated an increased risk for liver damage as well as concerns over its interaction with other medications.  

Safety

It is also important to remember that CBD products are not regulated by the U.S. Food and Drug Administration (FDA). Some manufacturers make unproven claims about the uses and efficacy of their products. There is also concern about the quality and safety of the products themselves.

One report by the Centers for Disease Control and Prevention (CDC) indicated that a number of people experienced negative unwanted side effects due to CBD products that contained synthetic CBD, although the products were not labeled as containing such ingredients.

Mislabeling appears to be a fairly common problem with CBD products. In one study, 70% of the CBD products that were sold online contained significantly more of the psychoactive ingredient THC than the label indicated.

Federal law prohibits the sale of products that contain more than 0.3% THC. States laws also vary, so you should always check with your state before buying CBD products online.

A Word From Verywell

If you do decide to take CBD to alleviate an acute or chronic condition, remember that the amount that you take will depend on a variety of factors. Finding the right dosage often takes some experimentation and adjustments. Starting with a low dose and then gradually increasing the amount you take until you achieve the desired effects is the best approach.

CBD Dosage: How Much Should You Take?

Commissions we earn from partner links on this page do not affect our opinions or evaluations. Our editorial content is based on thorough research and guidance from the Forbes Health Advisory Board.

Table of Contents

  • Determining the Best CBD Dosage for You
  • How to Calculate CBD Dosage
  • How to Take CBD

Cannabidiol (CBD) is growing increasingly popular, thanks to its many purported health benefits and non-intoxicating properties (most CBD products contain less than 0.3% tetrahydrocannabinol, or THC). In fact, 60% of U.S. adults have tried CBD at some point and believe it has medicinal benefits, according to a recent Forbes Health survey of 2,000 U.S. adults conducted by OnePoll. As research evolves and sheds light on CBD’s efficacy, especially for pain relief, more and more people are adding it to their daily wellness regimens.

Consumers can choose from a variety of CBD products, from oils to gummies to vapes to capsules. But figuring out the safe and effective CBD dose for an individual is a complex decision.

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Here’s how to find the right CBD dosage for you and how to consume it safely.

Determining the Best CBD Dosage for You

With the exception of one CBD product, a prescription drug used to treat seizures associated with particular syndromes, the Food and Drug Administration (FDA) doesn’t regulate the use of CBD. (In fact, it’s illegal to market CBD as a supplement or add it to food.) Therefore, it’s best to consult a doctor with experience in CBD administration to determine your ideal dosage.

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Expressed in milligrams (mg), CBD dosage largely depends on the conditions and symptoms you’re trying to treat and your unique endocannabinoid system, which is associated with motor control, behavior, emotions, the nervous system and homeostasis. CBD dosage remains an area of active research—more large, high-quality studies are needed in different populations to determine appropriate dosing, efficacy and safety guidelines.

“It’s best to start small and gradually increase your dose up to a level that gives you the desired effect,” says Cheryl Bugailiskis, M.D., a cannabis specialist at Heally, a telehealth platform for alternative medicine. Your starting point might look like half a CBD gummy or a drop of oil. Ideally, navigate this process under the guidance of a qualified physician.

If you’re still not sure where to start, mydosage.com offers a questionnaire and CBD calculator to help you based on your specific symptoms and usage goals.

How to Calculate CBD Dosage

When you consume CBD gummies, capsules or softgels, dosage is typically expressed per unit. For example, there may be 50 milligrams of CBD in each individual gummy. These products don’t offer much dosage flexibility since you can’t split up capsules easily. For instance, if one softgel capsule didn’t provide your desired result, you would have to take another full capsule, doubling the total dose.

CBD oil, on the other hand, makes it easier, to begin with a small dose. But calculating CBD oil dosage can be less straightforward. Oils and tinctures tend to come in a dropper bottle and, typically, only the total liquid volume and CBD contents are listed on the label. For example, the label might simply state there’s 1,500 milligrams of CBD in the 30-milliliter bottle.

But what does 1 milliliter look like? Due to the current lack of regulation of CBD, this calculation can be tricky. Start by figuring out the volume of a single drop in your dropper, which is usually 0.05 milliliters, according to Dr. Bugailiskis. If you’re unsure, ask the company.

Here’s where math comes in. Let’s continue with the 30-milliliter bottle with 1,500 milligrams of CBD and 0.05 milliliters in a single drop as our example.

1500mg÷30mL = 50 mg/mL

This bottle contains 50 milligrams of CBD per milliliter. Let’s see how many milligrams are in a drop:

50mg/mL ×0.05mL/drop = 2.5mg/drop

Each drop contains 2.5 milligrams of CBD.

Next, you can calculate how many drops you need to reach your goal dosage. Let’s say you want to consume 25 milligrams each day.

25mg÷2.5mg/drop = 10 drops
10 drops ×2.5mg = 0.5mL

With this CBD oil dosage calculator as your guide, you would find that you needed to consume 10 drops, or 0.5 milliliters, to reach 25 milligrams. And if you intend to consume 25 milligrams daily, you can expect this particular bottle to serve as a 60-day supply.

Some CBD products do some of this math for you and illustrate how many milligrams are in a milliliter, some even marking these points on the dropper so you know exactly what you’re taking.

CBD Dosage for Different Ailments

Without FDA approval, there is little guidance in the U.S. on how much CBD a person should consume for various conditions.

In many medical studies on CBD, you see administered doses reach hundreds of milligrams a day, which sounds severe compared to our starting dosage example of 25 milligrams. However, Steven Phan, founder of Come Back Daily, a CBD dispensary in New York, points out that patients in these studies are often dealing with serious flare-ups and pain-inducing conditions compared to everyday dispensary customers.

Below are clinically-studied CBD dosages based on different ailments and conditions. Note: Some of the formulations studied contained THC as well—not all available dosage research sticks strictly to CBD.

Condition Dose* Anxiety 300mg–600 milligrams a day [1] Linares, Ila M. et al. Cannabidiol presents an inverted U-shaped dose-response curve in a simulated public speaking test . Brazilian Journal of Psychiatry. 2019;41(1):9-14. [2] Bergamaschi MM, Queiroz RH, Chagas MH, et al. Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naïve social phobia patients . Neuropsychopharmacology. 2011;36(6):1219-1226. Select forms of epilepsy Starting at 2.5 milligrams per kilogram of the person’s body weight twice daily [3] EPIDIOLEX- cannabidiol solution. DailyMed. Accessed 7/4/2021. Central neuropathic and cancer-related pain A maximum of 30 milligrams a day (or 12 sprays) [4] Sativex Oromucosal Spray – Summary of Product Characteristics (SmPC) – (emc). Datapharm. Accessed 7/4/2021. Opioid addiction 400 or 800 milligrams a day [5] Hurd YL, Spriggs S, Alishayev J, et al. Cannabidiol for the Reduction of Cue-Induced Craving and Anxiety in Drug-Abstinent Individuals With Heroin Use Disorder: A Double-Blind Randomized Placebo-Controlled Trial. American Journal of Psychiatry. 2019;176(11):911-922. Arthritis A maximum of 30 milligrams a day (or 12 sprays), or 250 milligrams applied topically [4] Sativex Oromucosal Spray – Summary of Product Characteristics (SmPC) – (emc). Datapharm. Accessed 7/4/2021.

*Dosages are based solely on small, short-term clinical study results where CBD proved significantly successful over placebo. Much larger studies are needed to further strengthen the evidence.

FDA-approved Epidiolex administers CBD orally as a liquid to treat seizures associated with Lennox-Gastaut syndrome, Dravet syndrome and tuberous sclerosis complex. The dosage of Epidiolex is determined by taking the patient’s weight in kilograms (kg) into account.

Several countries, including Canada and those in the U.K., have approved the use of Sativex, an oral spray with equal amounts of CBD and THC, to treat pain stemming from multiple sclerosis. Canada has also approved it for treatment of cancer pain.

The medical and research community still has a long way to go before figuring out what dose works best for each condition. At an individual level, consumers can experiment with caution until they find what works best for them.

Partner Offers feature brands who paid Forbes Health to appear at the top of our list. While this may influence where their products or services appear on our site, it in no way affects our ratings, which are based on thorough research, solid methodologies and expert advice. Our partners cannot pay us to guarantee favorable reviews of their products or services

Medterra Isolate CBD Oil

How to Take CBD

Popular ways to take CBD include:

  • Oils and tinctures (extracts of plant material dissolved in ethanol): A liquid that comes in a bottle with a dropper
  • Gummies: A soft, chewable candy that’s often fruit-flavored
  • Sprays: A liquid that comes in a bottle with a nozzle for spraying into the mouth
  • Capsules: Tablets or softgels that are ingested by mouth
  • Vapes: CBD oil that’s heated without ignition, resulting in an inhalable vapor
  • Flower: Dried hemp plant that’s often ignited and smoked
  • Edibles: Any food that CBD oil has been added to, such as brownies or chips
  • Drinks: Any beverage that’s infused with CBD, often in the form of hemp extract

Your CBD product of choice will largely depend on your personal preferences, as well as your budget since prices vary depending on the potency of ingredients and manufacturing processes. Different mediums also offer varying levels of bioavailability—or how much of what you take is actually absorbed into your bloodstream to have an effect. For example, if you ingest 10 milligrams of CBD via 1 milliliter of liquid, your body might absorb about 60% of it, or about 6 milligrams.

Cannabinoids generally have a low bioavailability compared to other substances, according to Jordan Tishler, M.D., a physician specializing in cannabis treatment in Massachusetts. However, “products that contain emulsifiers like egg yolk (brownies) or lecithin (some gummies) do better,” he says.

With that said, ingesting CBD via gummies or other edibles may take longer to take effect since the CBD has to travel to your digestive system to be broken down and absorbed.

Can You Take Too Much CBD?

Like with any substance, you can take more CBD than your body can handle. Studies show doses up to 1,500 milligrams a day have been well-tolerated, but every person is different [7] Bergamaschi MM, Costa Queiroz RH, Zuardi AW, Crippa JAS. Safety and side effects of cannabidiol, a Cannabis sativa constituent. Current Drug Safety. 2011;6(4):237-49. . Ingesting too much CBD can cause unpleasant side effects, such as dry mouth, nausea, diarrhea, upset stomach, drowsiness, lightheadedness and general disorientation. While rare, liver damage can also occur.

What’s more, CBD can have serious interactions with certain medications. In evaluating available information on five prescription CBD-based medications, researchers found 139 medications could have a potential drug-drug interaction with CBD [8] Kocis PT, Vrana KE. Delta-9-Tetrahydrocannabinol and Cannabidiol Drug-Drug Interactions. Medical Cannabis and Cannabinoids. 2020;3:61–73. . People who take certain blood thinners, heart rhythm medications, thyroid medications and seizure medications need to be particularly careful.

At the end of the day, not all supplements are created equal, which is why it’s important to work alongside a health care provider when adding CBD to your wellness regimen and research reliable brands. And while emerging research and anecdotal evidence is promising, more large, randomized-controlled trials are needed to further understand the benefits of CBD and its dosing.