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How much cbd oil for dementia

Effects of THC-Free CBD Oil on Agitation in Patients With Alzheimer’s Disease

This is a randomized, double-blinded, placebo-controlled, crossover trial that aims to 1) determine the efficacy of THC-free cannabidiol (CBD oil) in reducing the severity of agitation among participants and 2) determine whether THC-free CBD oil can reduce the burden on caregivers and increase the participants’ quality of life.

Condition or disease Intervention/treatment Phase
Alzheimer Disease Dementia Major Neurocognitive Disorder With Aggressive Behavior Drug: THC-free CBD Oil Drug: Placebo Phase 2

Individuals with Alzheimer’s and other forms of dementia often go through a period of significant behavioral and psychological symptoms of dementia (BPSD). It is estimated that up to 90% of persons with dementia (PWD) experience behavior problems at some point. BPSDs can be challenging for both unpaid family caregivers as well as paid caregivers. Family caregivers provide the bulk of care for PWD and number over 15 million. One of the most common types of BPSDs is agitation with a prevalence of up to 87%, based on a recent systematic review. Agitation can lead to impaired daily functioning, prolongation of hospitalization, reduced time to institutionalization, and is associated with higher mortality. Additionally, agitated behavior is associated with increased injury to both patients and caregivers. Based on the 2018 Alzheimer’s disease drug development pipeline report almost 70% of clinical trials related to BPSD are dedicated to agitation behavior. Finding ways to address agitation is necessary to improve overall quality of life for PWD and their caregivers. Currently, there are no medications available specifically for the treatment of BPSDs. The use of benzodiazepines, antipsychotics and mood stabilizing agents are common, but the risks and side effects often outweigh any benefits.

Several small studies have investigated the use of cannabinoids in the treatment of pathology and symptomology of Alzheimer’s disease (AD), as well as treatment of the agitation component of BPSD. A handful of these studies showed that the symptoms of BPSD were decreased with the use of cannabinoids. However, due to small sample sizes, study design, and short trial duration of these studies, the efficacy of these agents on BPSD cannot be confirmed. In addition, cannabinoids have demonstrated anti-oxidant and anti-inflammatory effects, and both processes have been indicated as major contributors to the neurologic effects of AD. Some evidence exists that agitation is related to this neuroinflammatory process. This study will examine the effects of cannabinoids on the behavioral and psychological symptoms of individuals with a dementia diagnosis.

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Can CBD Help Seniors with Alzheimer’s & Dementia?

CBD, or cannabi diol , has been suggested as a treatment to help seniors with dementia manage their symptoms. While there is currently no evidence to show that CBD can stop, reverse, or prevent dementia , there is research that sho ws that it could help manage symptoms. This could be great news for families and seniors who are struggling with the effects of dementia. In this post, we will explore what CBD is along with how CBD can be used to help seniors deal with Alzheimer’s or related dementias.

What Is CBD?

Let’s start with the basics of CBD. It comes from the hemp plant , which is related to the marijuana plant . The plant is dried and the resin is extracted. This compound contains 2 parts: tetrahydrocannabinol (THC) and cannabidiol (CBD).

  • THC is the recreational form of cannabis, which is associated with generating a “high.” In the US, products with more than 0.2% THC are considered illegal.
  • CBD is the medicinal form of cannabis that generally helps improve mood and reduce damage caused by inflammation. It does not CBD is legal in various forms in 47 US states. It also does not exhibit the potential for dependence or health-related problems.

This distinction is important because CBD does not have the intoxicating feeling associated with THC. Instead, it has been shown t o have anti-anxiety properties that can help manage behavior and promote calm. Additionally, CBD is the main ingredient in recent FDA-approved medication, Epidiolex, to treat epilepsy.

CBD can be administered in different forms, but the most common is as oil, which can be dropped onto the tongue , contained in gel capsule s, or applied to the skin directly. However, it is also available in pill forms or as an inhalant.

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What Are the Benefits of CBD for Seniors with Dementia?

CBD is commonly used to help with anxiety, insomnia, poor sleep, and even pain relief. B ecause CBD has been shown to help reduce anxiety and agitation, it is believed that it can help reduce these symptoms in seniors with dementia.

Because of how dementia affects the brain, a senior may become agitated or anxious in everyday situations. Sometimes this agitation can even turn vio lent. But remember that these behavior changes are caused by the disease and are not your loved one’s fault. CBD may be able to help alleviate these symptoms .

Additionally, Dementia Care Central indicates that CBD may also help:

  • Reduce inflammation
  • Reduce oxygen buildup
  • Stimulate the brain & reduce the decline of memory and other brain functions

Let’s dive deeper into how CBD could help in each of these areas.

Inflammation

Inflammation is the body’s natural response to injury. You might be used to seeing inflammation around a cut or wound. However, neuroinflammation is also associated with various forms of dementia. For example, Alzheimer’s disease causes clumps of proteins to build up in the brain. This can make it harder for the brain to function over time. As a result, the body may respond with inflammation in the area, which could make it even harder for the brain to make connections. However, CBD may help reduce that inflammation and help with dementia.

Oxygen Buildup

Oxygen buildup ties in with inflammation in the brain. As brain tissue expands, oxygen is released. So, the more inflammation, the more oxygen that builds up. As more oxygen is released into the brain, the brain loses functionality. This can result in memory loss or other brain deterioration. Oxygen is also released when the body is stressed, which happens often for seniors with dementia. CBD may help reduce stress and reduce the negative effects of oxygen on the brain.

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Memory & Brain Function

As dementia progresses, brain tissue actually dies and function is lost for good. This process can take the time or it can happen very rapidly. In some trials, CBD showed promising results to help stop or even reverse the loss of brain function and memory loss in dementia patients. Additionally, CBD may help stimulate the brain to help keep connections within the brain and help seniors potentially delay the effects of dementia.

While this information gives us much hope in the fight against dementia, know that only small clinical trials have been conducted to determine the effects of CBD on dementia, making it difficult to come to a scientific conclusion. However, scientists are continuing to conduct rese arch to help further our ability to help those with dementia.

Are There Any Risks Associated with CBD?

The World Health Organization (WHO ) has stated that “no public health problems. have been associated with the use of pure CBD.” Additionally, it does not exhibit addictive properties and has not been shown to cause any health risks.

However, this applies to pure CBD. There are some retailers who produce CBD products with other ingredients or strains of CBD that have been tainted with other substances. Some companies also misrepresent their products and place different packaging labels on the products. This could pose a risk for your loved one, so i t’s important for you to obtain any CBD products through a company that has been approved by a third party , meaning the products have been tested independently for quality.

If you or your loved one is interested in using CBD to manage symptoms, make sure you talk to a doctor first to evaluate the risks and discuss the best options.

There is still much we do not know when it comes to CBD and its effectiveness in treating the symptoms of dementia. However, we are hopeful that new research and medications will be developed that will end dementia for good!