What Drugs Will Interact with My Pet’s CBD?
While we still do not even know the extent that people’s medications will interact with CBD, even less is known about pet CBD medication interactions. That is simply because the research is lacking for both, especially in the pet field.
My veterinarian will not talk to me about CBD, but I would still like to make an educated decision on whether or not giving them CBD would be for the best.
We understand that this can be a very frustrating issue for a lot of pet parents. While CBD can cause some pet medications to be more or even less effective if consumed with CBD, there are similar precautions that have to be taken when giving your pet herbal supplements or even vitamins. There is always going to be a chance of interactions. The extent of them depends on body chemistry and prescription dose. What will affect one pet, may not affect another.
When CBD is ingested orally at large doses a group of liver enzymes in your pet may be temporarily altered. One of the most common interactions that relate to this is grapefruit for humans. CBD is also metabolized by cytochrome P450 enzymes preventing it from metabolizing other compounds.
“The extent to which cannabidiol behaves as a competitive inhibitor of cytochrome P450 depends on how tightly CBD binds to the active site of the metabolic enzyme before and after oxidation. This can change greatly, depending on how – and how much – CBD is administered, the unique attributes of the individual taking this medication, and whether isolated CBD or a whole-plant remedy is used.” – Adrain Devitt-Lee, a researcher at Project CBD.
60% of all medications are metabolized in the liver via specific enzymes produced in it. CBD, like grapefruit, temporarily uses up the enzymes and/or inhibiting the action of others.
Drugs that may be used for pain relief in your pet such as NSAIDs (anti-inflammatory drugs), Tramadol, Gabapentin or anxiety relief such as Prozac all rely on the P450 enzymes. This does not mean your pet can’t take CBD, it just means you might want to be a little more careful when dosing it at first. And CBD can be a wonderful way to hopefully have your pet use less of the above medications.
NSAIDs can wreak havoc on the stomach and liver over long term use.
Tramadol and Gabapentin usually require an increased dose over time because the body gets used to it.
Prozac and any other anti-anxiety will have withdrawal symptoms if given over a period of time. Please do not ever take your pet off of these medications cold-turkey. It is very very important your pet is titrated down slowly off of them.
Here is how one of our clients uses CBD and Prozac together-
“I give my dog Blooming Culture pet CBD oil on a daily basis to help with her generalized anxiety. When we travel or fly I up her dose of CBD that day and add in her veterinarian prescribed Prozac. I have found in conjunction they work really well together for extreme circumstances.”
One of the biggest known and visible side-effects of dosing your pet CBD with any of these medications is tiredness, which can be easily remedied by adjusting their dose.
If you are thinking about switching your pet off their prescription medication or trying to lower their dose, do it slowly. You can first start with a low dose of CBD and talking to your veterinarian on the best way to ween off the particular medication.
All Drug Interactions are Not Negative
Since CBD can also enhance the effects of certain medications, this means that a lower dose of that medication or therapy can sometimes be used, which is a positive.
Drugs used for dog seizures is one. Since CBD also has its own anti-seizure properties, it has proven to work well in human clinical trials together with anti-seizure medications. The AKC Health Foundation recently announced that it will begin a major clinical trial to study the potential for pet CBD oil for use in drug-resistant epileptic dogs.
The second is chemotherapy. Dogs receiving chemotherapy for cancer tend to have a lot of unwanted side effects. Many pet parents use CBD oil as a way to curb some of them and make their pet more comfortable. The same way people going through radiation may use CBD or cannabis. But recent research has shown that giving CBD oil to your pet in conjunction with radiation actually may make chemotherapy more effective.
Some research states that CBD triggers TRPV2 channels, making the cancer cells more sensitive to chemotherapy.
A different study showed that rats with pancreatic cancer had 3X the survival rate when given CBD in conjunction with chemotherapy instead of only chemotherapy.
Again, please work with your veterinarian as much as possible to make sure every medication, natural or not is working together safely on your pet.
*This article is for informational purposes only. If you have pet medication interaction concerns, please always consult with your veterinarian first.
How To Wean Dogs Off Gabapentin: Must-Know Tips To Avoid Withdrawal
Gabapentin is a human anticonvulsant sometimes used by veterinarians to treat chronic pain in dogs, cats, and other pets. If you need to wean your dog off gabapentin, it’s important to do it slowly rather than cold turkey in order to minimize side effects. This article contains everything you need to know about gabapentin: what it is, how it works, potential side effects, and how to wean your dog off of it.
What Is Gabapentin and How Does It Work?
Gabapentin is a human medication that’s used off-label in veterinary treatment. This means it’s not FDA-approved for pets. However, this drug is sometimes effective in treating seizures, anxiety, and chronic pain in dogs. Chronic pain conditions treated by gabapentin include arthritis, cancer, and pain sensitivity conditions. It also enhances the impact of other pain-relieving drugs such as NSAIDs or opiates.
Gabapentin works to block certain signals in the brain, reducing a dog’s capacity to experience pain.
Gabapentin is available in pill, tablet, or liquid form. You may administer gabapentin to your pet with or without food, but if your pet vomits after taking it on an empty stomach, consider providing it with food or a reward in the future. Giving this medicine just before a meal is optimal.
What Are the Withdrawal Symptoms of Gabapentin in Dogs?
Some of the symptoms of gabapentin withdrawal are similar to those of alcohol withdrawal. This resemblance is possibly related to the fact that gabapentin and several other drugs all work on GABA. GABA is a neurotransmitter that blocks certain signals in the brain and calms the nervous system.
Furthermore, dogs (or people!) who use gabapentin for seizures and stop taking it abruptly may suffer a resurgence in seizures or more frequent seizures. Continual, uncontrollable seizures may also occur in some cases.
How Long Does Gabapentin Sedation Last in Dogs?
The effects of this short-acting treatment will wear off in 24 hours; however, in dogs with renal or hepatic disease, the medication may continue longer.
When used to treat seizures, this medicine should not be suddenly discontinued since it might cause withdrawal seizures. Always check with your veterinarian before weaning your dog off of any medication.
How Long Until Gabapentin Kicks in for Dogs?
This drug should take action within 1 to 2 hours, and clinical symptoms should improve as a result.
What if I Forget to Give My Pet His Medication?
If you forget to give your pet a dosage, administer it as soon as you realize. If it’s almost time for the next dose, skip the missed dose and take it at the next planned time, then resume your usual dosing schedule. Give your pet no more than two doses at a time.
Are There Any Adverse Effects That I Should Be Aware Of?
Sedation (sleepiness) and ataxia (lack of coordination) are the most common side effects of gabapentin. Other potential side effects include vomiting, diarrhea, and loss of appetite. In certain severe cases, dogs may develop breathing problems, swelling of the face and/or muzzle, blue gums and/or tongue, or excessive drooling. To reduce these side effects, gradually increase the dosage of the drug over time.
The effects of this short-acting drug should wear off in 24 hours, however, they may last longer in dogs with liver or renal illness.
The good news is that the adverse effects of gabapentin are usually minor. They also usually go away within a few days as your dog responds to the medicine. If you see any side effects that concern you, please contact your veterinarian and ask about changing your dog’s dosage.
Be careful when administering liquid gabapentin to your pup, as it sometimes contains the sweetener xylitol, which is toxic for dogs.
How Much Gabapentin Can I Give My Dog for Anxiety?
Gabapentin is generally dosed at 5-30 mg per kg of weight up to three times daily in dogs. Gabapentin is also used as a sedative at 30-60 mg/kg one to two hours before a stressful event, such as a vet appointment, on an as-needed basis.
Experts recommend starting at the low end of the dosage range and gradually increasing the dosage. Space dosage increases seven days apart to allow for evaluation of the impact.
What Are Some Strategies for Reducing Side Effects?
Your veterinarian may recommend providing gabapentin exclusively in the evening for a few days to allow your dog to acclimate. As a result, the negative effects will occur when your dog is already asleep. When your dog is asleep, a little additional sedation isn’t an issue. Lack of coordination is also less of a problem since pups don’t tend to sleepwalk. Your doctor may suggest increasing the dose frequency to every 8 to 12 hours as your dog adapts.
If your dog takes an antacid, don’t administer gabapentin for at least two hours. Antacids reduce gabapentin absorption, which may reduce its therapeutic advantages.
When providing gabapentin to dogs who are already on morphine, phenobarbital, or potassium bromide, or are taking CBD oil, take caution. Gabapentin-associated sedation may be more severe in these pets. If drowsiness doesn’t go away after a couple of days, consult your vet about a dosage adjustment.
Is Gabapentin Covered By Pet Insurance?
Yes! A quality pet insurance plan will cover the cost of prescription drugs like Gabapentin. Most plans have similar terms to insurance plans for people though, so pre-existing conditions may not be covered.
We have been using pet insurance for over ten years and it has saved us lots over the years. The biggest benefit to us is not having financial concerns come into play when having to make tough decisions when it comes to medical care. Pets age much faster than we do, and vet bills add up, especially later in a pet’s life.
We highly recommend Embrace Pet Insurance! They are on the more affordable end of the spectrum and offer great service. Get a free quote from Embrace Pet Insurance. You can also check out our full review of pet insurance plans in our article What Is The Best Pet Insurance: 4 Recommended Plans.
Summary: How to Wean Your Dog Off Gabapentin
Gabapentin is a human pharmaceutical that’s often used to treat seizures, anxiety, and chronic pain in dogs. It’s relatively safe and effective to administer gabapentin to your pup as long as you take the proper precautions.
However, if you need to wean your dog off gabapentin, don’t do it cold turkey. Abruptly stopping this medication can cause seizures and other withdrawal symptoms. Instead, slowly decrease your pet’s dosage and frequency over a period of 2-3 weeks. Consult your veterinarian for further instruction before weaning your dog off gabapentin.